1-docosyl-piperazine | 1018908-25-2

• 物质功能分类: 医药中间体 - 杂环化合物 - 哌嗪类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-docosyl-piperazine
• 英文别名: 1-Docosylpiperazine；1-docosylpiperazine
• CAS: 1018908-25-2
• 化学式: C₂₆H₅₄N₂
• 分子量: 394.728
• InChiKey: ZZXAGOXVIGMKKZ-UHFFFAOYSA-N

物化性质

• 沸点：
  488.1±20.0 °C(Predicted)
• 密度：
  0.855±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  10.6
• 重原子数：
  28
• 可旋转键数：
  21
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-docosyl-piperazine 、 4-氯甲基苯甲酰氯 在 三乙胺 作用下， 以 苯 为溶剂， 生成
  参考文献：
  名称：

  Design of new potent and selective secretory phospholipase A2 inhibitors. Part 5: Synthesis and biological activity of 1-alkyl-4-[4,5-dihydro-1,2,4-[4H]-oxadiazol-5-one-3-ylmethylbenz-4′-yl(oyl)] piperazines

  摘要：

  Among the different PLA(2)s identified to date, the group IIA secretory PLA(2) (sPLA(2) GIIA) is implied in diverse pathological conditions. In this work we describe the synthesis, inhibitory activities, and structure-activity relationships (SAR) of a new class of substituted piperazine derivatives. The in vitro fluorimetric assay using two groups of enzymes, GIB and GIIA, revealed several compounds as highly potent inhibitors (IC50 = 0.1 mu M). The in vivo activity assessed by ip or per os administration in a carrageenan-induced edema test in rats showed that two compounds proved to be as potent as indomethacin (10 mg/kg). (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.10.077
• 作为产物：
  描述：

  哌嗪 、 1-溴二十二烷 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 1-docosyl-piperazine
  参考文献：
  名称：

  Design of new potent and selective secretory phospholipase A2 inhibitors. Part 5: Synthesis and biological activity of 1-alkyl-4-[4,5-dihydro-1,2,4-[4H]-oxadiazol-5-one-3-ylmethylbenz-4′-yl(oyl)] piperazines

  摘要：

  Among the different PLA(2)s identified to date, the group IIA secretory PLA(2) (sPLA(2) GIIA) is implied in diverse pathological conditions. In this work we describe the synthesis, inhibitory activities, and structure-activity relationships (SAR) of a new class of substituted piperazine derivatives. The in vitro fluorimetric assay using two groups of enzymes, GIB and GIIA, revealed several compounds as highly potent inhibitors (IC50 = 0.1 mu M). The in vivo activity assessed by ip or per os administration in a carrageenan-induced edema test in rats showed that two compounds proved to be as potent as indomethacin (10 mg/kg). (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.10.077

文献信息

• ALKANOLAMINE, FRICTION-REDUCING AGENT, AND LUBRICATING OIL COMPOSITION
  申请人：TOSOH CORPORATION

  公开号：US20200039942A1

  公开（公告）日：2020-02-06

  To provide a friction-reducing agent containing no sulfur nor phosphorus and being excellent in friction-reducing properties, and a lubricating oil composition using it. An alkanolamine represented by the following formula is used as a friction-reducing agent: wherein A 1 and A 2 are each independently a hydroxy group or a hydrogen atom, provided that A 1 and A 2 are not hydrogen atoms at the same time, R 1 is a hydrocarbon group having at most 30 carbon atoms, R 2 to R 6 are each independently a hydrogen atom or a hydrocarbon group having at most 30 carbon atoms, and m and n are each independently an integer of from 0 to 10.

  提供一种不含硫和磷、在减摩性能方面表现优异的减摩剂，以及使用该减摩剂的润滑油组合物。作为减摩剂使用以下式表示的脂肪胺：其中A1和A2分别独立地是羟基或氢原子，前提是A1和A2不同时是氢原子，R1是最多有30个碳原子的烃基，R2到R6分别独立地是氢原子或最多有30个碳原子的烃基，m和n分别独立地是0到10的整数。
• Alkanolamine, friction-reducing agent, and lubricating oil composition
  申请人：TOSOH CORPORATION

  公开号：US10927084B2

  公开（公告）日：2021-02-23

  To provide a friction-reducing agent containing no sulfur nor phosphorus and being excellent in friction-reducing properties, and a lubricating oil composition using it. An alkanolamine represented by the following formula is used as a friction-reducing agent: wherein A1 and A2 are each independently a hydroxy group or a hydrogen atom, provided that A1 and A2 are not hydrogen atoms at the same time, R1 is a hydrocarbon group having at most 30 carbon atoms, R2 to R6 are each independently a hydrogen atom or a hydrocarbon group having at most 30 carbon atoms, and m and n are each independently an integer of from 0 to 10.

  提供一种不含硫和磷且具有优异减摩性能的减摩剂，以及使用该减摩剂的润滑油组合物。使用下式表示的烷醇胺作为减摩剂： 其中 A1 和 A2 各自独立地为羟基或氢原子，但 A1 和 A2 不能同时为氢原子；R1 为最多具有 30 个碳原子的烃基；R2 至 R6 各自独立地为氢原子或最多具有 30 个碳原子的烃基；m 和 n 各自独立地为 0 至 10 的整数。
• Design of new potent and selective secretory phospholipase A2 inhibitors. Part 5: Synthesis and biological activity of 1-alkyl-4-[4,5-dihydro-1,2,4-[4H]-oxadiazol-5-one-3-ylmethylbenz-4′-yl(oyl)] piperazines
  作者：Latifa Boukli、Mohamed Touaibia、Nadia Meddad-Belhabich、Atimé Djimdé、Chang-Ha Park、Jung-Joo Kim、Joo-Hyoung Yoon、Aazdine Lamouri、Françoise Heymans

  DOI：10.1016/j.bmc.2007.10.077

  日期：2008.2.1

  Among the different PLA(2)s identified to date, the group IIA secretory PLA(2) (sPLA(2) GIIA) is implied in diverse pathological conditions. In this work we describe the synthesis, inhibitory activities, and structure-activity relationships (SAR) of a new class of substituted piperazine derivatives. The in vitro fluorimetric assay using two groups of enzymes, GIB and GIIA, revealed several compounds as highly potent inhibitors (IC50 = 0.1 mu M). The in vivo activity assessed by ip or per os administration in a carrageenan-induced edema test in rats showed that two compounds proved to be as potent as indomethacin (10 mg/kg). (c) 2007 Elsevier Ltd. All rights reserved.