哌嗪类化合物
哌嗪类化合物是指含有哌嗪结构的一类重要医药中间体，广泛应用于生产驱肠虫药物如磷酸哌嗪和枸橼酸哌嗪，以及氟奋乃静、强痛定和利福平等其他药物。此外，这些化合物也被用于制造湿润剂、乳化剂、分散剂等表面活性剂，以及抗氧剂、防腐剂、稳定剂等塑料加工助剂与橡胶助剂。
哌嗪又名六氢吡嗪或二亚乙基二胺。从乙醇中析出的哌嗪为白色斜方晶系叶片状结晶，具有温和的胺臭和咸味，并具备吸湿性。其相对密度为0.876，熔点为106.6℃，沸点为146℃。该化合物易溶于水和甘油，微溶于乙醇而不溶于乙醚。哌嗪具有强碱性，10%的水溶液pH值在10.8～11.8之间，并能吸收空气中的二氧化碳。对眼睛和皮肤有刺激作用，具有典型的仲胺反应。它可通过乙二胺与1,2-二氯乙烷反应或由氨基乙醇高温下二聚而制得。无机酸及有机酸盐用作人和动物的驱肠虫药物，是驱除蛔虫、蛲虫的有效药物，并用于有机合成。
哌嗪又称为“驱蛔灵”，对蛔虫和蛲虫均有较强作用。该药能使虫体肌肉发生松弛性麻痹，防止其随肠道蠕动被排出体外。使用时不会出现兴奋现象，相对安全。可用于治疗由蛔虫引起的不完全肠梗阻及早期胆道蛔虫病，亦适用于伴有溃疡病的患者。一般剂量治愈率可达70%～80%，连续用药2天可提高治愈率。治疗蛲虫病需连续服药7～10天。该药物毒性较低，治疗量下偶尔会出现恶心、呕吐或荨麻疹等副作用。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| 高哌嗪 | 1,4-Diazacycloheptane | 505-66-8 | C5H12N2 |
|
| 间羟基苯基哌嗪 | 3-(piperazin-1-yl)phenol | 59817-32-2 | C10H14N2O |
|
| 苯甲基增哌嗪羧酸酯 | benzyl 1,4-diazepane-1-carboxylate | 117009-97-9 | C13H18N2O2 |
|
| 苯甘孢霉素环二肽 | 2-(3,6-Dioxo-5-phenylpiperazin-2-yl)-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | 59865-11-1 | C16H17N3O4S |
|
| 苯基丙基哌嗪 | 1-(3-phenylpropyl)piperazine | 55455-92-0 | C13H20N2 |
|
| 肉桂基哌嗪 | trans-1-cinnamylpiperazine | 87179-40-6 | C13H18N2 |
|
| 羟丙哌嗪 | Dropropizin | 17692-31-8 | C13H20N2O2 |
|
| 维拉佐酮中间体5-(哌嗪-1-基)苯并呋喃-2-甲酸乙酯 | ethyl 5-(piperazin-1-yl)benzofuran-2-carboxylate | 163521-20-8 | C15H18N2O3 |
|
| 紫外线吸收剂UV-350 | 2-(4-Methylpiperazin-1-YL)cyclopentanol | 915921-53-8 | C10H20N2O |
|
| 甲基-[2-(4-甲基-1-哌嗪)-乙基]-胺 | N-methyl-2-(4-methylpiperazin-1-yl)ethanamine | 98545-15-4 | C8H19N3 |
|
| 氯硝柳胺哌嗪盐 | Niclosamide piperazine | 34892-17-6 | C17H18Cl2N4O4 |
|
| 氯三氟甲基苯基哌嗪 | 1-(4-Chloro-3-trifluoromethyl-phenyl)-piperazine | 41213-04-1 | C11H12ClF3N2 |
|
| 氨基哌嗪盐酸盐 | 1-aminopiperazine | 30651-60-6 | C4H11N3 |
|
| 氧哌嗪酸 | (R)-<<(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl>amino>(4-hydroxyphenyl)acetic acid | 62893-24-7 | C15H17N3O6 |
|
| 托那哌嗪 | 1,2,3,4-Tetrahydro-6-hydroxy-2-[4-(2-methylphenyl)-1-piperazinyl]-naphthalene | 70312-00-4 | C21H26N2O |
|
| 左羟丙哌嗪 | dextrodropropizine | 99291-24-4 | C13H20N2O2 |
|
| 左羟丙哌嗪 | levodropropizine | 99291-25-5 | C13H20N2O2 |
|
| 四磷酸哌喹四水合物;4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物 | Piperaquine tetraphosphate tetrahydrate | 915967-82-7 | C29H52Cl2N6O20P4 |
|
| 四氢糠酰哌嗪 | N-(tetrahydro-2-furoyl)-piperazine | 63074-07-7 | C9H16N2O2 |
|
| 喹哌嗪 | 2-(piperazin-1-yl)quinoline | 4774-24-7 | C13H15N3 |
|
| 哌嗪硫酸盐 | piperazinium sulfate | 4554-26-1 | C4H12N2*O4S |
|
| 哌嗪柠檬酸盐水合物 | tripiperazine dicitrate | 144-29-6 | 3C4H10N2*2C6H8O7 |
|
| 哌嗪DL-苹果酸盐 | Piperazine DL-Malate | 14852-14-3 | C8H16N2O5 |
|
| 哌嗪-2-甲醛 | piperazine-2-aldehyde | 773866-77-6 | C5H10N2O |
|
| 哌嗪-2-甲醇 | 2-hydroxymethylpiperazine | 28795-50-8 | C5H12N2O |
|
| 哌嗪-2-甲酰胺 | piperazine-2-carboxamide | 84501-64-4 | C5H11N3O |
|
| 哌嗪-2,6-二酮盐酸盐 | piperazine-2,6-dione hydrochloride | 35975-30-5 | C4H6N2O2*ClH |
|
| 哌嗪-2,3,5,6-四酮 | piperazine-2,3,5,6-tetraone | 49715-78-8 | C4H2N2O4 |
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| 哌嗪-1-羧酸甲酯 | methyl piperazine-1-carboxylate | 50606-31-0 | C6H12N2O2 |
|
| 哌嗪-1-羧酸二甲胺 | piperazine-1-carboxylic acid dimethylamide | 41340-78-7 | C7H15N3O |
|
| 哌嗪-1-甲酸盐酸盐 | piperazine-1-carboxamide hydrochloride | 474711-89-2 | C5H11N3O*ClH |
|
| 哌嗪-1-甲酸叔丁酯醋酸盐 | 1-piperazinecarboxylic acid 1,1-dimethylethyl ester acetate | 143238-38-4 | C2H4O2*C9H18N2O2 |
|
| 哌嗪-1-甲胺 | p-aminomethylpiperazine | 18190-85-7 | C5H13N3 |
|
| 哌嗪-1-乙醇二盐酸盐 | Piperazine-1-ethanol dihydrochloride | 5712-71-0 | C6H16Cl2N2O |
|
| 哌嗪-1,4-二羧酸二乙酯 | diethyl piperazine-1,4-dicarboxylate | 5470-28-0 | C10H18N2O4 |
|
| 哌嗪-1,4-二乙酸 | 2,2'-(piperazine-1,4-diyl)diacetic acid | 5430-78-4 | C8H14N2O4 |
|
| 哌嗪(六水) | Piperazine hexahydrate | 142-63-2 | C4H22N2O6 |
|
| 吩嗪-1-羧酸 | tubermycin B | 2538-68-3 | C13H8N2O2 |
|
| 叔丁基-4-(2-羟乙基)哌嗪-1-羧酸酯 | tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate | 77279-24-4 | C11H22N2O3 |
|
| 伊马替尼间-甲基-哌嗪 | N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-3-((4-methylpiperazin-1-yl)methyl)benzamide | 1246819-59-9 | C29H31N7O |
|
| 二苯甲基哌嗪 | diphenylmethylpiperazine | 841-77-0 | C17H20N2 |
|
| 乙酸茶碱哌嗪盐 | acepifylline piperazine | 18833-13-1 | C4H10N2*2C9H10N4O4 |
|
| 乙基(2R)-2-[(3S,5aS,8aS,9aS)-3-甲基-1,4-二氧代十氢-2H-环戊二烯并[4,5]吡咯并[1,2-a]吡嗪-2-基]-4-苯基丁酸酯 | ramipril dioxopiperazine | 108731-95-9 | C23H30N2O4 |
|
| 三苯己哌嗪 | <i>N</i>-(2-{4-[4,4-bis-(4-fluoro-phenyl)-butyl]-piperazin-1-yl}-ethyl)-aniline | 5522-39-4 | C28H33F2N3 |
|
| 丁基哌嗪-1-羧酸 | 1-butyloxycarbonylpiperazine | 50606-32-1 | C9H18N2O2 |
|
| {8-氟-2-[4-(3-甲氧基苯基)-1-哌嗪基]-3-[2-甲氧基-5-(三氟甲基)-苯基]-3,4-二氢-4-喹唑啉基}-乙酸甲酯 | methyl 2-[8-fluoro-3-[2-methoxy-5-(trifluoromethyl)phenyl]-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3,4-dihydroquinazolin-4-yl] acetate | 791117-40-3 | C30H30F4N4O4 |
|
| {4- [4-(2-噻吩基羰基)哌嗪-1-基]苯基}胺 | (4-(4-aminophenyl)piperazin-1-yl)(thiophen-2-yl)methanone | 412331-95-4 | C15H17N3OS |
|
| [4-(羟基甲基)哌嗪-1-基]甲醇 | N,N'-piperazinediethanol | 3312-58-1 | C6H14N2O2 |
|
| N1-γ-氯丙基-N4-β-羟乙基哌嗪 | 2-(4-(3-chloropropyl)piperazin-1-yl)ethan-1-ol | 57227-28-8 | C9H19ClN2O |
|
| N-苯基哌嗪 | 4-phenyl-1-piperazine | 92-54-6 | C10H14N2 |
|
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