5,6,3-trihydroxyindole | 3569-19-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5,6,3-trihydroxyindole
• 英文别名: noradrenolutine；indole-3,5,6-triol；Indol-3,5,6-triol；1H-indole-3,5,6-triol
• CAS: 3569-19-5
• 化学式: C₈H₇NO₃
• 分子量: 165.148
• InChiKey: TYTJJQZBTLMGRT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  76.5
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,5,6-triacetoxy-indole 在 sodium hydroxide 、 sodium dithionite 、 水 作用下， 生成 5,6,3-trihydroxyindole
  参考文献：
  名称：

  152.黑色素及其前体。第二部分 醌和吲哚之间反应的模型实验，并考虑黑色素聚合物的可能结构

  摘要：

  DOI：

  10.1039/jr9510000703

文献信息

• 152. Melanin and its precursors. Part II. Model experiments on the reactions between quinones and indoles, and consideration of a possible structure for the melanin polymer
  作者：John D. Bu'Lock、John Harley-Mason

  DOI：10.1039/jr9510000703

  日期：——
• Kruk, I., Zeitschrift fur Physikalische Chemie (Leipzig), 1987, vol. 268, # 3, p. 607 - 613
  作者：Kruk, I.

  DOI：——

  日期：——
• Chakraborty; Roy; Chakraborty, Journal of the Indian Chemical Society, 1989, vol. 66, # 8-10, p. 699 - 702
  作者：Chakraborty、Roy、Chakraborty、Rakshit

  DOI：——

  日期：——
• METHOD OF PREPARING COATING FILM CONTAINING NITROGEN MONOXIDE ON SURFACE OF MATERIAL USING CATECHOLAMINE
  申请人：POSTECH ACADEMY-INDUSTRY FOUNDATION

  公开号：US20140127277A1

  公开（公告）日：2014-05-08

  A method of coating surfaces of various body-implantable materials with control-releasable nitrogen monoxide using a catecholamine, more particularly, technology of preparing a coating film containing a diazeniumdiolate functional group on a surface of a material to be coated using a catecholamine, is provided. The coating film prepared by the method has advantages in that nitrogen monoxide can be stably supplied under an in vivo environment, and can be suitably used in a living body without causing cytotoxicity. Therefore, among the materials having a coating film formed on a surface thereof, the body-implantable material is especially expected to be widely used for medical and health applications including treatment of ischemic disorders such as arteriosclerosis through controlled release of nitrogen monoxide, regulation of penile erections, antibacterial and antiviral effects, and wound healing.
• UV-OVERPROTECTING IRIDESCENT COLORED CONTACT LENSES
  申请人：The University of Akron

  公开号：US20210373358A1

  公开（公告）日：2021-12-02

  In various embodiments, the present invention is directed to contact lenses that utilize a multilayer coating of alternating high RI materials, such as melanin or polydopamine (PDA) and other low RI materials to create tunable iridescent colors and contain melanin or similar materials that impart photoprotection due to their broadband UV-vis absorption spectrum and ability to quench radicals.