7-methoxy-5-methyl-1,2,3,4-tetrahydronaphthalene | 78250-66-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 7-methoxy-5-methyl-1,2,3,4-tetrahydronaphthalene
• 英文别名: methyl-(4-methyl-5,6,7,8-tetrahydro-[2]naphthyl)-ether；Methyl-(4-methyl-5,6,7,8-tetrahydro-[2]naphthyl)-aether
• CAS: 78250-66-5
• 化学式: C₁₂H₁₆O
• 分子量: 176.258
• InChiKey: VWZZAICVQCAFCD-UHFFFAOYSA-N

物化性质

• 沸点：
  64 °C(Press: 0.098 Torr)
• 密度：
  0.998±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  7-methoxy-5-methyl-1,2,3,4-tetrahydronaphthalene 在 盐酸 、 溴 、 zinc(II) chloride 作用下， 以 溶剂黄146 、 丙酸 为溶剂， 反应 24.25h， 生成 7-bromo-5-(chloromethyl)-6-methoxy-8-methyl-1,2,3,4-tetrahydronaphthalene
  参考文献：
  名称：

  Cameron, Donald W.; Feutrill, Geoffrey I.; Griffiths, Peter G., Australian Journal of Chemistry, 1981, vol. 34, # 2, p. 459 - 464

  摘要：

  DOI：
• 作为产物：
  描述：

  间甲基苯甲醚 在 盐酸 、 氢氧化钾 、 三氯化铝 、 PPA 、 一水合肼 、 汞 、 锌 作用下， 以 硝基苯 为溶剂， 反应 27.0h， 生成 7-methoxy-5-methyl-1,2,3,4-tetrahydronaphthalene
  参考文献：
  名称：

  Shanker, Sathya P.; Rao, Subba G. S. R., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1995, vol. 34, # 4, p. 271 - 279

  摘要：

  DOI：

文献信息

• Herbicidal cyclohexane-1,3-dione derivatives
  申请人：ICI Australia Limited

  公开号：US04640708A1

  公开（公告）日：1987-02-03

  Compounds of the formula ##STR1## wherein: R.sup.5 is a bicyclic aryl or nitrogen-containing heteroaryl ring system such as naphthyl, quinolyl, isoquinolyl or tetrahydroisoquinolyl, optionally substituted by a wide variety of groups; R.sup.4 and R.sup.1 are preferably hydrogen but may be other groups and R.sup.2 and R.sup.3 are selected from alkyl, haloalkyl, alkenyl, haloalkenyl and alkynyl, show high general grass-killing activity with good selectivity to many broad-leaf crops and in some instances selectivity to small-grain cereals. Processes for the preparation of compounds of formula I, intermediates in the preparation of compounds I and the herbicidal properties of compounds I are described.

  公式为##STR1##的化合物，其中：R.sup.5是双环芳基或含氮杂芳基环系统，如萘基、喹啉基、异喹啉基或四氢异喹啉基，可选择性地被各种基团取代；R.sup.4和R.sup.1最好是氢，但也可以是其他基团，R.sup.2和R.sup.3选自烷基、卤代烷基、烯基、卤代烯基和炔基，在对许多广叶作物具有高度杀草活性的同时，对一些小粒谷物具有良好的选择性。描述了制备公式I化合物的方法，制备公式I化合物的中间体以及公式I化合物的除草性能。
• Herbicidal cyclohexane-1,3-dione-5-isoquinoline derivatives
  申请人：ICI Australia Limited

  公开号：US04680400A1

  公开（公告）日：1987-07-14

  The invention concerns novel compounds of the formula I ##STR1## wherein: A, B, D and E are selected from CH, N and N-Z wherein Z is selected from oxygen and the group YAn wherein Y is selected from alkyl and benzyl and An is an anion, and provided that no more than three of A, B, D and E are selected from N and N-Z and no more than one of A, B, D and E is selected from N-Z; W is a saturated or unsaturated C.sub.2 to C.sub.5 hydrocarbon chain; X and X.sup.1 are independently selected from halogen, nitro, cyano, alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, alkenyl, alkenyloxy, alkynyl, alkynyloxy, acyloxy, alkoxycarbonyl, alkylthio, alkylsulfinyl, alkylsulfonyl, sulfamoyl, substituted sulfamoyl, alkanoyloxy, benzyloxy, substituted benzyloxy, amino, substituted amino and the groups formyl and alkanoyl and the oxime, imine and Schiff base derivatives thereof, or two of X.sup.1 on the same carbon atom may form an oxo group; R.sup.1 is selected from hydrogen, alkyl, alkenyl, alkynyl, substituted alkyl, alkylsulfonyl, arylsulfonyl, acyl and an inorganic or organic cation; R.sup.2 is selected from alkyl, substituted alkyl, alkenyl, haloalkenyl, alkynyl and haloalkynyl; R.sup.3 is selected from alkyl, fluoroalkyl, alkenyl, alkynyl, and phenyl; R.sup.4 is selected from hydrogen, halogen, alkyl, cyano and alkoxycarbonyl; n is 0 or an integer chosen from 1 to 3; and n.sup.1 is 0 or an integer chosen from 1 to 5. The compounds of the invention show herbicidal properties and plant growth regulating properties and in further embodiments the invention provides processes for the preparation of compounds of formula I, intermediates useful in the preparation of the compounds of formula I, compositions containing as active ingredient a compound of formula I, and herbicidal and plant growth regulating processes utilizing compounds of formula I.

  本发明涉及化合物I的新型化合物，其化学式为：##STR1##其中：A、B、D和E选择自CH、N和N-Z，其中Z选择自氧和YAn基团，其中Y选择自烷基和苯甲基，An是阴离子，并且保证A、B、D和E中最多只有三个选择自N和N-Z，最多只有一个选择自N-Z；W是饱和或不饱和的C.sub.2至C.sub.5烃基链；X和X.sup.1独立选择自卤素、硝基、氰基、烷基、取代烷基、羟基、烷氧基、取代烷氧基、烯基、烯氧基、炔基、炔氧基、酰氧基、烷氧羰基、烷基硫基、烷基亚磺酰基、烷基磺酰基、磺酰胺基、取代磺酰胺基、烷酰氧基、苄氧基、取代苄氧基、氨基、取代氨基和甲酰基和烷酰基及其氧肟、亚胺和席夫碱衍生物，或X.sup.1中的两个在同一碳原子上可以形成氧代基；R.sup.1选择自氢、烷基、烯基、炔基、取代烷基、烷基磺酰基、芳基磺酰基、酰基和无机或有机阳离子；R.sup.2选择自烷基、取代烷基、烯基、卤代烯基、炔基和卤代炔基；R.sup.3选择自烷基、氟烷基、烯基、炔基和苯基；R.sup.4选择自氢、卤素、烷基、氰基和烷氧羰基；n为0或从1到3选择的整数；n.sup.1为0或从1到5选择的整数。本发明的化合物具有除草和植物生长调节性能，在进一步实施中，本发明提供了制备化合物I的工艺、制备化合物I的中间体、含有化合物I作为活性成分的组合物以及利用化合物I进行除草和植物生长调节的过程。
• The Dehydrogenation and Structure Proof of 1-Methylestrone¹
  作者：Andre S. Dreiding、Walter J. Pummer

  DOI：10.1021/ja01109a036

  日期：1953.7
• CAMERON D. W.; FEUTRILL G. J.; GRIFFITHS P. G., AUSTRAL. J. CHEM. 1981, 34 NO 2, 459-464
  作者：CAMERON D. W.、 FEUTRILL G. J.、 GRIFFITHS P. G.

  DOI：——

  日期：——
• BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS
  申请人：BIOGEN MA INC.

  公开号：US20190209592A1

  公开（公告）日：2019-07-11

  Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.