4-(9-Azidononyl)pyridin-2-amine | 904325-32-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(9-Azidononyl)pyridin-2-amine
• 英文别名: 4-(9-azidononyl)pyridin-2-amine
• CAS: 904325-32-2
• 化学式: C₁₄H₂₃N₅
• 分子量: 261.37
• InChiKey: NINIHRBSIRCAAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  53.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(9-Azidononyl)pyridin-2-amine 、 2-ethyl-2-(1-propyn-3-yl)barbituric acid 在 copper(II) sulfate 、 sodium ascorbate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 12.0h， 以97%的产率得到5-((1-(9-(2-aminopyridin-4-yl)nonyl)-1H-1,2,3-triazol-4-yl)methyl)-5-ethylpyrimidine-2,4,6(1H,3H,5H)-trione
  参考文献：
  名称：

  Recyclable Self-Assembly-Supported Catalyst for Chelation-Assisted Hydroacylation of an Olefin with a Primary Alcohol

  摘要：

  A novel recyclable catalyst for chelation-assisted hydroacylation of an olefin with a primary alcohol was developed by utilizing a hydrogen-bonding self-assembly motif consisting of a barbiturate bearing 2-aminopyridin-4-yl group and 5-hexyl-2,4,6-triaminopyrimidine. This was further applied to a mixed catalyst system to recycle both organic and organometallic catalysts.

  DOI：

  10.1021/ol0608045
• 作为产物：
  描述：

  1,8-二溴辛烷 在 正丁基锂 、 sodium azide 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 4-(9-Azidononyl)pyridin-2-amine
  参考文献：
  名称：

  Recyclable Self-Assembly-Supported Catalyst for Chelation-Assisted Hydroacylation of an Olefin with a Primary Alcohol

  摘要：

  A novel recyclable catalyst for chelation-assisted hydroacylation of an olefin with a primary alcohol was developed by utilizing a hydrogen-bonding self-assembly motif consisting of a barbiturate bearing 2-aminopyridin-4-yl group and 5-hexyl-2,4,6-triaminopyrimidine. This was further applied to a mixed catalyst system to recycle both organic and organometallic catalysts.

  DOI：

  10.1021/ol0608045

文献信息

• Recyclable Self-Assembly-Supported Catalyst for Chelation-Assisted Hydroacylation of an Olefin with a Primary Alcohol
  作者：Do-Won Kim、Sung-Gon Lim、Chul-Ho Jun

  DOI：10.1021/ol0608045

  日期：2006.7.1

  A novel recyclable catalyst for chelation-assisted hydroacylation of an olefin with a primary alcohol was developed by utilizing a hydrogen-bonding self-assembly motif consisting of a barbiturate bearing 2-aminopyridin-4-yl group and 5-hexyl-2,4,6-triaminopyrimidine. This was further applied to a mixed catalyst system to recycle both organic and organometallic catalysts.