1,3,5-tris(1,10-phenanthroline-[5,6-d]imidazol-2-yl)-benzene | 796889-04-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1,3,5-tris(1,10-phenanthroline-[5,6-d]imidazol-2-yl)-benzene
• 英文别名: 1,3,5-tris(1,10-phenanthroline-[5,6-d]imidazol-2-yl)benzene；tpbip；2-[3,5-bis(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenyl]-1H-imidazo[4,5-f][1,10]phenanthroline
• CAS: 796889-04-8
• 化学式: C₄₅H₂₄N₁₂
• 分子量: 732.766
• InChiKey: LSCCTFLNERCTRB-UHFFFAOYSA-N

物化性质

• 密度：
  1.571±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  57
• 可旋转键数：
  3
• 环数：
  13.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  163
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  顺-双(2,2'-二吡啶基)二氯化钌(II)二水合物 、 1,3,5-tris(1,10-phenanthroline-[5,6-d]imidazol-2-yl)-benzene 以 乙二醇 为溶剂， 生成 [(bpy)6Ru3(tpbip)]Cl6
  参考文献：
  名称：

  Trinuclear Ru(II) polypyridyl complexes as human telomeric quadruplex DNA stabilizers

  摘要：

  Two new trinuclear ruthenium(II) complexes [(bpy)(6)Ru-3(tpbip)](6+) (1) and [(bPY)(6)Ru-3(tptaip)](6+) (2) (bpy=2,2'-bipyridine, tpbip=1,3,5-tris(1,10-phenanthroline-[5,6-d]imidazol-2-yl)-benzene, tptaip=2,4,6-tri(1,10-phenanthroline-[5,6-d]imidazol-2-yl)-1,3,5-triazine) have been synthesized and characterized. The interaction of human telomeric DNA with Ru(II) complexes was explored by means of CD spectroscopy, fluorescence titration, ITC and FRET melting. Results indicated that two complexes not only induce a remarkable conformational change of human telomeric DNA, but also have the ability to stabilize the C-quadruplex. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.inoche.2010.06.008
• 作为产物：
  描述：

  均苯三甲酸 、 5,6-二氨基-1,10-邻菲罗啉 在 polyphosphoric acid 作用下， 反应 12.0h， 以70%的产率得到1,3,5-tris(1,10-phenanthroline-[5,6-d]imidazol-2-yl)-benzene
  参考文献：
  名称：

  Trinuclear Ru(II) polypyridyl complexes as human telomeric quadruplex DNA stabilizers

  摘要：

  Two new trinuclear ruthenium(II) complexes [(bpy)(6)Ru-3(tpbip)](6+) (1) and [(bPY)(6)Ru-3(tptaip)](6+) (2) (bpy=2,2'-bipyridine, tpbip=1,3,5-tris(1,10-phenanthroline-[5,6-d]imidazol-2-yl)-benzene, tptaip=2,4,6-tri(1,10-phenanthroline-[5,6-d]imidazol-2-yl)-1,3,5-triazine) have been synthesized and characterized. The interaction of human telomeric DNA with Ru(II) complexes was explored by means of CD spectroscopy, fluorescence titration, ITC and FRET melting. Results indicated that two complexes not only induce a remarkable conformational change of human telomeric DNA, but also have the ability to stabilize the C-quadruplex. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.inoche.2010.06.008

文献信息

• pH-induced molecular switch of a novel trinuclear Ru(II) polypyridyl complex
  作者：Feixiang Cheng、Ning Tang

  DOI：10.1016/j.inoche.2008.01.014

  日期：2008.5

  10-phenanthroline-[5,6-d]imidazol-2-yl)benzene (L) and corresponding novel trimetallic Ru(II) polypyridyl complex [(bpy)6L(RuII)3](PF6)6 have been synthesized. UV–vis absorption and fluorescence spectra of the complex change obviously over the pH range 1.82–12.29. This complex acts as pH-induced off–on–off fluorescence switch through protonation and deprotonation in buffer solution.

  摘要 配体 1,3,5-三(1,10-菲咯啉-[5,6-d]咪唑-2-基)苯 (L) 和相应的新型三金属 Ru(II) 多吡啶配合物 [(bpy)6L(RuII) )3](PF6)6 已经合成。复合物的紫外-可见吸收和荧光光谱在 pH 值范围 1.82-12.29 内明显变化。该复合物通过缓冲溶液中的质子化和去质子化作用作为 pH 诱导的关-开-关荧光开关。