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(2-allyl-phenyl)-propyl ether | 100256-20-0

中文名称
——
中文别名
——
英文名称
(2-allyl-phenyl)-propyl ether
英文别名
(2-Allyl-phenyl)-propyl-aether;1-(Prop-2-en-1-yl)-2-propoxybenzene;1-prop-2-enyl-2-propoxybenzene
(2-allyl-phenyl)-propyl ether化学式
CAS
100256-20-0
化学式
C12H16O
mdl
MFCD14582752
分子量
176.258
InChiKey
ZDCZHCBHMIXNCD-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    4.2
  • 重原子数:
    13
  • 可旋转键数:
    5
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.333
  • 拓扑面积:
    9.2
  • 氢给体数:
    0
  • 氢受体数:
    1

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    (2-allyl-phenyl)-propyl ether氢溴酸 作用下, 生成 [2-(2-bromo-propyl)-phenyl]-propyl ether
    参考文献:
    名称:
    Horii; Inoi, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1957, vol. 77, p. 1095,1099
    摘要:
    DOI:
  • 作为产物:
    描述:
    参考文献:
    名称:
    Horii; Inoi, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1957, vol. 77, p. 1095,1099
    摘要:
    DOI:
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文献信息

  • [EN] BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT<br/>[FR] DÉRIVÉS BENZIMIDAZOLE EN TANT QUE BLOQUEURS SÉLECTIFS DU COURANT DE SODIUM PERSISTANT
    申请人:ALLERGAN INC
    公开号:WO2013101926A1
    公开(公告)日:2013-07-04
    The present invention is directed to methods of treating diseases or conditions mediated by elevated persistent sodium channel, such as ocular disorders, pain, multiple sclerosis, and seizure disorders utilizing a compound of Formula (I) or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising said compound, wherein variables R, R1, R2, R3, R4, R5, m, and n in Formula (I) are as defined herein.
    本发明涉及治疗由持续性钠通道升高介导的疾病或症状的方法,例如眼部疾病、疼痛、多发性硬化和癫痫症,利用化合物I的方法或其药学上可接受的盐或包含该化合物的药物组合物,其中化合物I中的变量R、R1、R2、R3、R4、R5、m和n如本文所定义。
  • Polyimide compositions
    申请人:SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.
    公开号:EP0469684A1
    公开(公告)日:1992-02-05
    Curable compositions which comprise: a) polyimides of the general formula (I) wherein B signifies a bivalent radical containing a carbon-carbon double bond, and wherein A represents an X-valent radical, but at least a bivalent radical; and b) alkenylphenoxyalkanes of the general formula (II) wherein D represents a Y-valent radical, Y is 1,2 or 3 and wherein E signifies a radical of the following formulae wherein R represents an alkyl group with 1 to 6 carbon atoms and R' a 1,2 or 2,3 alkenyl group with 3 to 8 carbon atoms.
    可治愈组合物,包括:a) 通式(I)中B表示含有碳-碳双键的二价基团,A表示X-价基团,但至少为二价基团的聚酰亚胺;b) 通式(II)中D表示Y-价基团,Y为1、2或3,E表示以下式子的基团:其中R表示1至6个碳原子的烷基,R'表示3至8个碳原子的1,2或2,3烯基基团的烷基。
  • BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT
    申请人:Allergan, Inc.
    公开号:US20130172342A1
    公开(公告)日:2013-07-04
    The present invention is directed to methods of treating diseases or conditions mediated by elevated persistent sodium channel, such as ocular disorders, pain, multiple sclerosis, and seizure disorders utilizing a compound of Formula I or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising said compound, wherein variables R, R 1 , R 2 , R 3 , R 4 , R 5 , m, and n in Formula I are as defined herein.
    本发明涉及使用I式化合物或其药学上可接受的盐或包含该化合物的药物组合物来治疗由持续性钠通道升高引起的疾病或症状,例如眼部疾病、疼痛、多发性硬化和癫痫等。其中,I式中的变量R、R1、R2、R3、R4、R5、m和n的定义如本文所述。
  • Process for preparing 1-bromoalkylbenzene derivatives and intermediates thereof
    申请人:SUMITOMO CHEMICAL COMPANY LIMITED
    公开号:EP0637580A1
    公开(公告)日:1995-02-08
    A 1-bromoalkylbenzene derivative is prepared by reacting a phenylalkene derivative with hydrogen bromide in the presence of a non-polar solvent. The phenylalkene derivative is prepared by reacting an alkenyl halide with metal magnesium to form a Grignard reagent, and then reacting the Grignard reagent with a benzyl halide derivative. An allyl Grignard reagent is prepared by reacting continuously an allyl halide derivative with metal magnesium in an organic solvent, in which the allyl halide derivative and metal magnesium are continuously added to the reaction system and the allyl Grignard reagent formed is continuously removed from the reaction system. The processes provide the intended compounds in high yields, high selectivities and high purities.
    1-bromoalkylbenzene derivative is prepared by reacting a phenylalkene derivative with hydrogen bromide in the presence of a non-polar solvent.苯基烷烃衍生物的制备方法是先使烯基卤化物与金属镁反应生成格氏试剂,然后使格氏试剂与苄基卤化物衍生物反应。烯丙基格氏试剂是通过烯丙基卤化物衍生物与金属镁在有机溶剂中连续反应制备的,其中烯丙基卤化物衍生物和金属镁被连续加入反应体系,形成的烯丙基格氏试剂被连续从反应体系中移除。这些工艺可提供高产率、高选择性和高纯度的预期化合物。
  • US5637736A
    申请人:——
    公开号:US5637736A
    公开(公告)日:1997-06-10
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