1-cyclohexyl-hexan-1-ol | 53398-70-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-cyclohexyl-hexan-1-ol
• 英文别名: Cyclohexyl hexanol；1-cyclohexylhexan-1-ol
• CAS: 53398-70-2
• 化学式: C₁₂H₂₄O
• 分子量: 184.322
• InChiKey: YOGRLTXNCLHZFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-cyclohexyl-hexan-1-ol 在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以87%的产率得到1-环己基己烷-1-酮
  参考文献：
  名称：

  Comparative inhibition of tetrameric carbonyl reductase activity in pig heart cytosol by alkyl 4-pyridyl ketones

  摘要：

  Context and objective: The present study is to elucidate the comparative inhibition of tetrameric carbonyl reductase (TCBR) activity by alkyl 4-pyridyl ketones, and to characterize its substrate-binding domain.Materials and methods: The inhibitory effects of alkyl 4-pyridyl ketones on the stereoselective reduction of 4-benzoylpyridine (4-BP) catalyzed by TCBR were examined in the cytosolic fraction of pig heart.Results: Of alkyl 4-pyridyl ketones, 4-hexanoylpyridine, which has a straight-chain alkyl group of five carbon atoms, inhibited most potently TCBR activity and was a competitive inhibitor. Furthermore, cyclohexyl pentyl ketone, which is substituted by cyclohexyl group instead of phenyl group of hexanophenone, had much lower ability to be reduced than hexanophenone.Discussion and conclusion: These results suggest that in addition to a hydrophobic cleft corresponding to a straight-chain alkyl group of five carbon atoms, a hydrophobic pocket with affinity for an aromatic group is located in the substrate-binding domain of TCBR.

  DOI：

  10.3109/14756366.2013.790021
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 、 铂 作用下， 生成 1-cyclohexyl-hexan-1-ol
  参考文献：
  名称：

  Braude et al., Journal of the Chemical Society, 1952, p. 1419,1424

  摘要：

  DOI：

文献信息

• Novel Syntheses of Secondary and Tertiary Alcohols from Alkynes via the Hydroboration Reaction
  作者：George ZWEIFEL、Richard P. FISHER

  DOI：10.1055/s-1974-23307

  日期：——
• PARTICLES HAVING HYDROPHOBIC MATERIAL THEREIN
  申请人：AUSTRALIAN NUCLEAR SCIENCE AND TECHNOLOGY ORGANISATION

  公开号：EP1906915A1

  公开（公告）日：2008-04-09
• Solution for immersion exposure and immersion exposure method
  申请人：Kagayama Akifumi

  公开号：US20090130604A1

  公开（公告）日：2009-05-21

  The object is to resolve a finer pattern with a narrower line/space width by immersion lithography technology in the manufacture of a semiconductor or the like. A liquid for use in immersion exposure includes a saturated hydrocarbon compound as a main component, wherein the content of an impurity or impurities having an unsaturated bond or a heteroatom in its structure is respectively as follows: (i) 2 μg/mL or less in total for a compound having a conjugated unsaturated bond; (ii) 30 μg/mL or less in total for a compound having no conjugated unsaturated bond but having a non-conjugated unsaturated bond; (iii) 15 μg/mL or less in total for amines having no unsaturated bond; and (iv) 100 μg/mL or less in total for a heterocyclic compound, alcohols, ethers and a halogen-containing compound, other than above compounds (i) to (iii).
• US4767883A
  申请人：——

  公开号：US4767883A

  公开（公告）日：1988-08-30
• US5674987A
  申请人：——

  公开号：US5674987A

  公开（公告）日：1997-10-07