2-(1-(4-methoxyphenyl)ethyl)-5-phenyl-1,3,4-oxadiazole | 1181219-14-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(1-(4-methoxyphenyl)ethyl)-5-phenyl-1,3,4-oxadiazole
• 英文别名: 2-[1-(4-Methoxyphenyl)ethyl]-5-phenyl-1,3,4-oxadiazole
• CAS: 1181219-14-6
• 化学式: C₁₇H₁₆N₂O₂
• 分子量: 280.326
• InChiKey: HLWVQXLPGOVCQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  48.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-甲氧基苯乙烯 、 2-苯基-1,3,4-噁二唑 在 bis(1,5-cyclooctadiene)nickel (0) 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 甲苯 为溶剂， 反应 3.0h， 以84%的产率得到2-(1-(4-methoxyphenyl)ethyl)-5-phenyl-1,3,4-oxadiazole
  参考文献：
  名称：

  Nickel-Catalyzed C−H Alkenylation and Alkylation of 1,3,4-Oxadiazoles with Alkynes and Styrenes

  摘要：

  The addition reaction of 1,3,4-oxadiazoles to alkynes via C-H bond cleavage efficiently proceeds in the presence of a nickel catalyst. This direct coupling allows a facile access to alkenyl-substituted oxadiazoles. The reaction with styrenes in place of alkynes is also available to selectively afford the corresponding branched adducts.

  DOI：

  10.1021/jo901350j

文献信息

• Copper-catalyzed direct cross-coupling of 1,3,4-oxadiazoles with N-tosylhydrazones: efficient synthesis of benzylated 1,3,4-oxadiazoles
  作者：N. Salvanna、Gandolla Chinna Reddy、Bethapudi Rama Rao、Biswanath Das

  DOI：10.1039/c3ra42791a

  日期：——

  The first copper catalyzed direct C–H benzylation of 1,3,4-oxadiazoles using N-tosylhydrazones has efficiently been accomplished. Several substituted oxadiazoles have been prepared in high yields (80–89%) in 3 h.

  首个铜催化的直接C–H苄基化1,3,4-噁二唑的反应已成功实现，使用了N-托磺基肼。多个取代的噁二唑在3小时内以高产率（80–89%）制备完成。
• Nickel-Catalyzed C−H Alkenylation and Alkylation of 1,3,4-Oxadiazoles with Alkynes and Styrenes
  作者：Tomoya Mukai、Koji Hirano、Tetsuya Satoh、Masahiro Miura

  DOI：10.1021/jo901350j

  日期：2009.8.21

  The addition reaction of 1,3,4-oxadiazoles to alkynes via C-H bond cleavage efficiently proceeds in the presence of a nickel catalyst. This direct coupling allows a facile access to alkenyl-substituted oxadiazoles. The reaction with styrenes in place of alkynes is also available to selectively afford the corresponding branched adducts.