2,6-di(3,5-dimethoxybenzylidene)cyclohexanone | 1260497-73-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 2,6-di(3,5-dimethoxybenzylidene)cyclohexanone
• 英文别名: 2,6-Di(3,5-dimethoxybenzylidene)cyclohexanone；2,6-bis[(3,5-dimethoxyphenyl)methylidene]cyclohexan-1-one
• CAS: 1260497-73-1
• 化学式: C₂₄H₂₆O₅
• 分子量: 394.467
• InChiKey: LCTMHSXNDBNPAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,5-二甲氧基苯甲醛 、 环己酮 在 carbon nanocage material CKT-3(A) 作用下， 反应 0.67h， 以92.3%的产率得到2,6-di(3,5-dimethoxybenzylidene)cyclohexanone
  参考文献：
  名称：

  Synthesis of Sulfonated Carbon Nanocage and Its Performance as Solid Acid Catalyst

  摘要：

  A carbon nanocage material (CKT) was first successfully sulfonated by introducing sulfophenyl groups on the surface of pore channels through benzenesulfonic acid-containing aryl radical in situ generated from the reaction of 4-aminobenzenesulfonic acid and isoamyl nitrite in water. The sulfonated carbon nanocage material (S-CKT) was characterized by Fourier transform infrared spectroscopy, transmission electron microscopy, powder small-angle X-ray diffraction and nitrogen sorption measurements. The results showed that the S-CKT still possess the high specific surface area (787 m(2)/g) and uniform mesoporous (pore diameter 4.7 nm) structures, although the structure of S-CKT is slightly disorder, compared with its unsulfonated precursor. S-CKT, as a carbon-based solid acid catalyst, showed good catalytic performance and reusability in the cross-Aldol condensation of ketones with aromatic aldehydes under solvent-free condition.

  DOI：

  10.1007/s10562-010-0526-6

文献信息

• A-(3,5-DIMETHOXY BENZYLIDENE)-A'-HYDROCARBYL METHYLENE CYCLIC KETONE AND PREPARATION METHOD THEREOF
  申请人：Pharmaxyn Laboratories Ltd.

  公开号：EP2927208A1

  公开（公告）日：2015-10-07

  The present invention discloses a α-(3,5-dimethoxybenzylidene)-α'-hydrocarbyl methylene cyclic ketone with the following structure: or wherein R is aryl or alkyl, its preparation method is: the cyclic ketone blended with morpholine are subjected to azeotropic dehydration to give enamine, the enamine is condensed with 3,5-dimethoxybenzaldehyde and then condensed with alkyl or aryl formaldehyde under acidic or basic conditions to give the product, the present invention further discloses an antitumor agent comprising α-(3,5-dimethoxybenzylidene)-α'-hydrocarbyl methylene cyclic ketone or medically acceptable salts and pharmaceutically acceptable carriers thereof. Through the above, the present invention providesα-(3,5-dimethoxybenzylidene)-α'-hydrocarbyl methylene cyclic ketone and preparation method thereof, the said compound is a high activity antitumor agent obtained by piecing and modifying the structures of natural anti-tumor active ingredient resveratrol and curcumin, which has a good inhibitory effect on epidermal growth factor receptor.

  本发明公开了一种结构如下的α-(3,5-二甲氧基亚苄基)-α'-氢羰基亚甲基环酮： 或 其中 R 为芳基或烷基，其制备方法为环酮与吗啉共沸脱水得到烯胺，烯胺与3,5-二甲氧基苯甲醛缩合，然后在酸性或碱性条件下与烷基或芳基甲醛缩合得到产品、本发明进一步公开了一种抗肿瘤剂，包括α-(3,5-二甲氧基亚苄基)-α'-氢羰基亚甲基环酮或医学上可接受的盐及其药学上可接受的载体。综上所述，本发明提供了α-(3,5-二甲氧基亚苄基)-α'-氢羰基亚甲基环酮及其制备方法，该化合物是通过对天然抗肿瘤活性成分白藜芦醇和姜黄素的结构进行拼接和修饰而得到的一种高活性抗肿瘤剂，对表皮生长因子受体具有良好的抑制作用。
• Synthesis of Sulfonated Carbon Nanocage and Its Performance as Solid Acid Catalyst
  作者：Pei Lin、Baolin Li、Jiangtao Li、Huichun Wang、Xiaobing Bian、Xiaomei Wang

  DOI：10.1007/s10562-010-0526-6

  日期：2011.3

  A carbon nanocage material (CKT) was first successfully sulfonated by introducing sulfophenyl groups on the surface of pore channels through benzenesulfonic acid-containing aryl radical in situ generated from the reaction of 4-aminobenzenesulfonic acid and isoamyl nitrite in water. The sulfonated carbon nanocage material (S-CKT) was characterized by Fourier transform infrared spectroscopy, transmission electron microscopy, powder small-angle X-ray diffraction and nitrogen sorption measurements. The results showed that the S-CKT still possess the high specific surface area (787 m(2)/g) and uniform mesoporous (pore diameter 4.7 nm) structures, although the structure of S-CKT is slightly disorder, compared with its unsulfonated precursor. S-CKT, as a carbon-based solid acid catalyst, showed good catalytic performance and reusability in the cross-Aldol condensation of ketones with aromatic aldehydes under solvent-free condition.