(+/-)-3-Hydroxy-hexakosansaeure | 122751-66-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (+/-)-3-Hydroxy-hexakosansaeure
• 英文别名: 3-Hydroxyhexacosanoic acid
• CAS: 122751-66-0
• 化学式: C₂₆H₅₂O₃
• 分子量: 412.697
• InChiKey: SEVRYJMBCDYSHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.2
• 重原子数：
  29
• 可旋转键数：
  24
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  三乙胺 、 (+/-)-3-Hydroxy-hexakosansaeure 、 (R)-1,1'-Bi-2-naphthol 在 硼酸三甲酯 作用下， 以 氘代氯仿 为溶剂， 反应 0.17h， 生成
  参考文献：
  名称：

  Peptidolipins B–F, Antibacterial Lipopeptides from an Ascidian-Derived Nocardia sp.

  摘要：

  A marine Nocardia sp. isolated from the ascidian Trididemnum orbiculatum was found to produce five new lipopeptides, peptidolipins B-F (1-5), which show distinct similarities to the previously reported L-Val(6) analog of peptidolipin NA. Synthetic modification of peptidolipin E (4) was used to determine the location of an olefin within the lipid chain. The advanced Marfey's method was used to determine the absolute configurations of the amino acids. Peptidolipins B (1) and E (4) demonstrated moderate antibacterial activity against methicillin-resistant Staphylococcus aureus and methicillin-sensitive Staphylococcus aureus.

  DOI：

  10.1021/np300016r
• 作为产物：
  描述：

  peptidolipin B 在 盐酸 作用下， 以 水 为溶剂， 反应 4.0h， 生成 (+/-)-3-Hydroxy-hexakosansaeure
  参考文献：
  名称：

  Peptidolipins B–F, Antibacterial Lipopeptides from an Ascidian-Derived Nocardia sp.

  摘要：

  A marine Nocardia sp. isolated from the ascidian Trididemnum orbiculatum was found to produce five new lipopeptides, peptidolipins B-F (1-5), which show distinct similarities to the previously reported L-Val(6) analog of peptidolipin NA. Synthetic modification of peptidolipin E (4) was used to determine the location of an olefin within the lipid chain. The advanced Marfey's method was used to determine the absolute configurations of the amino acids. Peptidolipins B (1) and E (4) demonstrated moderate antibacterial activity against methicillin-resistant Staphylococcus aureus and methicillin-sensitive Staphylococcus aureus.

  DOI：

  10.1021/np300016r

文献信息

• Peptidolipins B–F, Antibacterial Lipopeptides from an Ascidian-Derived <i>Nocardia</i> sp.
  作者：Thomas P. Wyche、Yanpeng Hou、Emmanuel Vazquez-Rivera、Doug Braun、Tim S. Bugni

  DOI：10.1021/np300016r

  日期：2012.4.27

  A marine Nocardia sp. isolated from the ascidian Trididemnum orbiculatum was found to produce five new lipopeptides, peptidolipins B-F (1-5), which show distinct similarities to the previously reported L-Val(6) analog of peptidolipin NA. Synthetic modification of peptidolipin E (4) was used to determine the location of an olefin within the lipid chain. The advanced Marfey's method was used to determine the absolute configurations of the amino acids. Peptidolipins B (1) and E (4) demonstrated moderate antibacterial activity against methicillin-resistant Staphylococcus aureus and methicillin-sensitive Staphylococcus aureus.