1-benzyloxy-17-bromoheptadecane | 144878-52-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-benzyloxy-17-bromoheptadecane
• 英文别名: 17-benzyloxy-1-bromoheptadecane；17-Bromoheptadecoxymethylbenzene
• CAS: 144878-52-4
• 化学式: C₂₄H₄₁BrO
• 分子量: 425.493
• InChiKey: YFCYWSJFKOQMKM-UHFFFAOYSA-N

物化性质

• 沸点：
  475.0±18.0 °C(Predicted)
• 密度：
  1.048±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.7
• 重原子数：
  26
• 可旋转键数：
  19
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-benzyloxy-17-bromoheptadecane 在 palladium on activated charcoal 正丁基锂 、 氢气 作用下， 以 四氢呋喃 、 乙醇 、 正己烷 、 乙腈 为溶剂， -78.0~20.0 ℃ 、101.33 kPa 条件下， 生成 18-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-yl]-octadecan-1-ol
  参考文献：
  名称：

  Effects of Indole Fatty Alcohols on the Differentiation of Neural Stem Cell Derived Neurospheres

  摘要：

  In a search for inducers of neuronal differentiation to treat neurodegenerative diseases such as Alzheimer's disease, a series of indole fatty alcohols (IFAs) were prepared. 13C (n = 18) was able to promote the differentiation of neural stem cell derived neurospheres into neurons at a concentration of 10 nM. Analysis of the expression of the Notch pathway genes in neurospheres treated during the differentiation phase with 13c (n = 18) revealed a significant decrease in the transcription of the Notch 4 receptor.

  DOI：

  10.1021/jm0493616
• 作为产物：
  描述：

  15-溴-1-十五烷醇 在 palladium on activated charcoal lithium aluminium tetrahydride 、 氢气 、 sodium hydride 、 pyridinium chlorochromate 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 为溶剂， 生成 1-benzyloxy-17-bromoheptadecane
  参考文献：
  名称：

  Effects of Indole Fatty Alcohols on the Differentiation of Neural Stem Cell Derived Neurospheres

  摘要：

  In a search for inducers of neuronal differentiation to treat neurodegenerative diseases such as Alzheimer's disease, a series of indole fatty alcohols (IFAs) were prepared. 13C (n = 18) was able to promote the differentiation of neural stem cell derived neurospheres into neurons at a concentration of 10 nM. Analysis of the expression of the Notch pathway genes in neurospheres treated during the differentiation phase with 13c (n = 18) revealed a significant decrease in the transcription of the Notch 4 receptor.

  DOI：

  10.1021/jm0493616

文献信息

• Pair-Wise Interactions by Gas Chromatography; Part III:^1,2Synthesis of Isosteric Stationary Phases for Gas Chromatography
  作者：Roland Cloux、Guy Défayes、Klára Fóti、Jean-Claude Dutoit、Ervin Sz. Kováts

  DOI：10.1055/s-1993-25968

  日期：——

  Retention in gas/liquid partition chromatography depends on the size and, to a lesser extent, on the form of the solvent used as stationary phase. How the measurement of interaction free enthalpies between a functional group and a solute free of size and form effects synthesis and properties of seven high molecular weight solvents is described. The monofunctional paraffin derivatives have the same form and nearly the same molar volume as that of their parent alkane 19,24-dioctadecyldotetracontane.

  在气/液分配色谱中，保留性取决于所用固定相溶剂的大小，以及在较小程度上取决于其形状。文章描述了功能团与无尺寸和形状影响的溶质之间的相互作用自由焓的测量方法，并介绍了七种高分子量溶剂的合成和性质。单功能石蜡衍生物与其母体烷烃19,24-二十八烷基四十六烷具有相同的形态和几乎相同的摩尔体积。
• Dutoit, Jean-Claude, Synthesis, 1992, # 20, p. 982 - 984
  作者：Dutoit, Jean-Claude

  DOI：——

  日期：——
• Effects of Indole Fatty Alcohols on the Differentiation of Neural Stem Cell Derived Neurospheres
  作者：Djalil Coowar、Julien Bouissac、Mazen Hanbali、Marie Paschaki、Eliane Mohier、Bang Luu

  DOI：10.1021/jm0493616

  日期：2004.12.1

  In a search for inducers of neuronal differentiation to treat neurodegenerative diseases such as Alzheimer's disease, a series of indole fatty alcohols (IFAs) were prepared. 13C (n = 18) was able to promote the differentiation of neural stem cell derived neurospheres into neurons at a concentration of 10 nM. Analysis of the expression of the Notch pathway genes in neurospheres treated during the differentiation phase with 13c (n = 18) revealed a significant decrease in the transcription of the Notch 4 receptor.