(3S,4S)-4-amino-3-hydroxy-6-methylheptanamide | 96402-62-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3S,4S)-4-amino-3-hydroxy-6-methylheptanamide
• CAS: 96402-62-9
• 化学式: C₈H₁₈N₂O₂
• 分子量: 174.243
• InChiKey: SHBYJEMETFUABH-BQBZGAKWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  89.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (2R,3S)-3-azido-1,2-epoxy-5-methylhexane 在 palladium on activated charcoal sodium hydroxide 、 氢气 、 双氧水 作用下， 以 甲醇 、 乙醇 、 水 、 叔丁醇 为溶剂， 25.0 ℃ 、275.79 kPa 条件下， 反应 5.0h， 生成 (3S,4S)-4-amino-3-hydroxy-6-methylheptanamide
  参考文献：
  名称：

  A new, versatile and stereospecific route to unusual amino acids: the enantiospecific total synthesis of statine amide and its three stereoisomers

  摘要：

  Total syntheses of statine amide [(3S,4S)-4-amino-3-hydroxy-6-methylheptanamide] and its three stereoisomers are described in order to illustrate the versatility of a new route to beta-hydroxy-gamma-amino acids. The enantioselective Sharpless epoxidation of a racemic allylic alcohol is used to generate chiral intermediates. The allylic alcohol, 3-hydroxy-5-methyl-1-hexene, can be prepared in at least two different ways from readily available materials. The methodology that is described should prove applicable to the synthesis of other analogues of statine.

  DOI：

  10.1021/jo00042a026

文献信息

• Hypotensive peptides and their use
  申请人：Sankyo Company Limited

  公开号：US04548926A1

  公开（公告）日：1985-10-22

  Oligopeptides of formula (I) ##STR1## (wherein R.sup.1 CO-- is an acyl group. But is an isobutyl or sec-butyl group and X is a variety of organic groups) and salts and esters thereof have valuable renin inhibitory activity.

  式(I)的寡肽 ##STR1## （其中R.sup.1 CO-是酰基。但是，它是异丁基或仲丁基基团，X是各种有机基团），以及它们的盐和酯具有有价值的肾素抑制活性。
• Identification of Compounds Modifying A Cellular Response
  申请人：Thastrup Ole

  公开号：US20090239755A1

  公开（公告）日：2009-09-24

  The present invention relates to methods for identifying compounds capable of modulating a cellular response. The methods involve attaching living cells to solid supports comprising a library of test compounds. The test compounds are linked to the solid support via cleavable linkers and may thus be released from the solid supports. Solid supports comprising cells, wherein the cellular response of interest has been modulated are selected and the test compound of the solid support can then be identified. The cellular response may for example be changes in complex formation between proteins.

  本发明涉及识别能够调节细胞反应的化合物的方法。该方法涉及将活细胞附着在包含测试化合物库的固体支撑体上。测试化合物通过可切割的连接剂与固体支撑体连接，因此可以从固体支撑体释放出来。选择细胞被固体支撑体调节了感兴趣的细胞反应的固体支撑体，并且可以鉴定固体支撑体上的测试化合物。细胞反应可以是蛋白质复合物形成的变化，例如。
• IDENTIFICATION OF COMPOUNDS MODIFYING A CELLULAR RESPONSE
  申请人：Thastrup Ole

  公开号：US20130123140A1

  公开（公告）日：2013-05-16

  The present invention relates to methods for identifying compounds capable of modulating a cellular response. The methods involve attaching living cells to solid supports comprising a library of test compounds. The test compounds are linked to the solid support via cleavable linkers and may thus be released from the solid supports. Solid supports comprising cells, wherein the cellular response of interest has been modulated are selected and the test compound of the solid support can then be identified. The cellular response may for example be changes in complex formation between proteins.

  本发明涉及识别能够调节细胞响应的化合物的方法。该方法包括将活细胞附着在包含一系列测试化合物的固体支持物上。测试化合物通过可切断的连接物与固体支持物相连，因此可以从固体支持物中释放出来。选择细胞响应已被调节的固体支持物，并可以鉴定固体支持物中的测试化合物。例如，细胞响应可以是蛋白质之间复合物形成的变化。
• New hypotensive peptides, their preparation and their use
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0128762A2

  公开（公告）日：1984-12-19

  Oligopeptides of formula (I) (wherein R1 CO- is an acyl group, But is an isobutyl or sec-butyl group and X is a variety of organic groups) and salts and esters thereof have valuable renin inhibitory activity and are prepared by conventional polypeptide synthesis.

  式 (I) 的寡肽（其中 R1 CO- 是酰基，But 是异丁基或仲丁基，X 是各种有机基团 (其中 R1 CO- 是酰基，But 是异丁基或仲丁基，X 是各种有机基团）及其盐和酯具有宝贵的肾素抑制活性，可通过常规多肽合成法制备。
• Affinity fishing for ligands and proteins receptors
  申请人：Novo Nordisk A/S

  公开号：EP2053403A2

  公开（公告）日：2009-04-29

  The invention provides putative "drugable" protein targets and actively binding ligands identified in an efficient and reproducible process by determining the affinity of protein mixtures to libraries of ligand compounds of defined size and composition. The libraries are used to isolate and identify previously unknown corresponding protein-ligand binding pairs from a mixture of proteins and a library of compounds, and are particularly useful to identify differentially selective protein-ligand binding pairs, for example, representing a single physiological state or several varied but related states, such as disease versus normal conditions. The invention also provides processes for identifying such protein-ligand binding pairs.

  本发明通过确定蛋白质混合物与确定大小和组成的配体化合物库的亲和力，以高效和可重复的过程鉴定推定的 "可药 "蛋白质靶标和活性结合配体。配体化合物库用于从蛋白质混合物和化合物库中分离和鉴定先前未知的相应蛋白质配体结合对，特别适用于鉴定具有不同选择性的蛋白质配体结合对，例如，代表单一生理状态或几种不同但相关的状态，如疾病与正常状态。本发明还提供了鉴定此类蛋白质配体结合对的方法。