(Z)-tert-Butyl 2-(((1-(2-aminothiazol-4-yl)-2-(benzo[d]thiazol-2-ylthio)-2-oxoethylidene)amino)oxy)-2-methylpropanoate | 89604-92-2

• 物质功能分类: 原料药 - 抗生素类药物 - 头孢菌素类药
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: (Z)-tert-Butyl 2-(((1-(2-aminothiazol-4-yl)-2-(benzo[d]thiazol-2-ylthio)-2-oxoethylidene)amino)oxy)-2-methylpropanoate
• 英文别名: tert-butyl 2-[(E)-[1-(2-amino-1,3-thiazol-4-yl)-2-(1,3-benzothiazol-2-ylsulfanyl)-2-oxoethylidene]amino]oxy-2-methylpropanoate
• CAS: 89604-92-2
• 化学式: C₂₀H₂₂N₄O₄S₃
• 分子量: 478.6
• InChiKey: RCZJVHXVCSKDKB-ZVHZXABRSA-N

物化性质

• 熔点：
  138-140°C
• 沸点：
  621.6±61.0 °C(Predicted)
• 密度：
  1.41±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿、甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  199
• 氢给体数：
  1
• 氢受体数：
  11

安全信息

• 安全说明：
  S61
• 危险类别码：
  R53
• 包装等级：
  III
• 危险类别：
  4.1
• 危险性防范说明：
  P261,P210,P264,P280,P370+P378,P302+P352+P312
• 危险品运输编号：
  1325
• 危险性描述：
  H302+H312+H332,H315,H319,H228

制备方法与用途

用途：用于制造头孢他啶等先锋类药物。

文献信息

• Cephem compounds, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0333082A2

  公开（公告）日：1989-09-20

  This invention provides a cephem compound of the formula (I): , wherein R¹ is an acyl group; R² is a carboxy group which may be esterified; R³ is hydrogen atom, a lower alkyl group or cyano group; R⁴ is hydrogen atom or a lower alkyl group ,or R⁴ together with R³ is a methylene chain having 2 or 3 carbon atoms; R⁵ is hydrogen atom or a lower alkyl group; A is an optionally substituted bivalent aromatic heterocyclic group which is bonded on the ring-constituting carbon atom with the adjacent sulfur atom; Y is a binding arm, sulfur or oxygen atom, -NH-, -CONH- or -NHCO-; Z is a binding arm or -NH-; m is an integer of 0 to 4 and n is an integer of 0 to 6, or a pharmacologically acceptable salt thereof, and a process for producing this compound.

  本发明提供了一种式(I)的头孢菌素化合物： 其中 R¹ 是酰基；R² 是可酯化的羧基；R³ 是氢原子、低级烷基或氰基；R⁴ 是氢原子或低级烷基，或 R⁴ 与 R³ 一起是具有 2 或 3 个碳原子的亚甲基链；R⁵ 是氢原子或低级烷基；A是任选取代的二价芳香杂环基团，其在成环碳原子上与相邻的硫原子键合；Y是结合臂、硫原子或氧原子、-NH-、-CONH-或-NHCO-；Z是结合臂或-NH-；m是0至4的整数，n是0至6的整数，或其药理学上可接受的盐，以及生产该化合物的工艺。
• MONOBACTAMS AND METHODS OF THEIR SYNTHESIS AND USE
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：US20160326157A1

  公开（公告）日：2016-11-10

  Described herein are monobactam antibiotics of Formula (I), (I′), (II), and (II′), along with methods and intermediates for preparing these compounds. Pharmaceutical compositions and methods of treating infectious diseases using the monobactams are also provided.
• WEATHER RESISTANCE IMPROVER, WEATHER RESISTANCE IMPROVER-CONTAINING RESIN COMPOSITION FOR COATING METAL NANOWIRE-CONTAINING LAYERS, AND METAL NANOWIRE-CONTAINING LAMINATE
  申请人：SEIKO PMC CORPORATION

  公开号：US20190194480A1

  公开（公告）日：2019-06-27

  The present invention relates to a weather resistance improver including a compound (A) and at least one of a compound (B) and a compound (C), in which the compound (A) is a compound represented by general formula (1) or (2) below, the compound (B) is gallic acid, a gallic acid derivative or tannic acid, and the compound (C) is a compound represented by general formula (3) below. Such a weather resistance improver can suppress degradation of a transparent conductive film including a metal nanowire both under long-term exposure to sunlight and under high humidity and high temperature conditions.
• US4971963A
  申请人：——

  公开号：US4971963A

  公开（公告）日：1990-11-20
• [EN] NEW CEPHEM COMPOUNDS
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：WO1992021683A1

  公开（公告）日：1992-12-10

  (EN) New cephem compounds of formula (I), wherein R1 is amino or protected amino, Z is N or CH, R2 is hydrogen or an organic group, and R3 is hydroxy or protected hydroxy, and pharmaceutically acceptable salts thereof which are useful as a medicament.(FR) Nouveaux composés cephem de la formule (I), dans laquelle R1 est un amino ou un amino protégé; Z est N ou CH; R2 est hydrogène ou un groupe organique; et R3 est un hydroxy ou un hydroxy protégé; et sels pharmaceutiquement acceptables de ces composés présentant une utilité en tant que médicament.