2-methoxy-[1,1'-biphenyl]-4-carbaldehyde | 248263-04-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methoxy-[1,1'-biphenyl]-4-carbaldehyde
• 英文别名: 3-methoxy-4-phenylbenzaldehyde
• CAS: 248263-04-9
• 化学式: C₁₄H₁₂O₂
• 分子量: 212.248
• InChiKey: DACZJTXMAHVFOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methoxy-[1,1'-biphenyl]-4-carbaldehyde 在 sodium borohydrid 作用下， 以 乙醇 为溶剂， 反应 0.83h， 生成 (2-methoxybiphenyl-4-yl)methanol
  参考文献：
  名称：

  Purinenucleoside derivative modified in 8-position and medical use thereof

  摘要：

  本发明提供了一种用于与血浆尿酸水平异常相关疾病的8-修饰嘌呤核苷衍生物。以下式（I）所代表的一种8-修饰嘌呤核苷衍生物、其前药或药用盐、或其水合物或溶剂化合物，对于痛风、高尿酸血症、尿路结石、高尿酸性肾病等的预防或治疗具有用处。在该式中，n为1或2；RA是氢原子或羟基；R1是氢原子、羟基、硫醇基、氨基或氯原子；环J代表可选地取代的2-萘基，或由以下一般式（II）所代表的基团，其中Y代表单键或连接基团；环Z代表可选地取代的芳基或杂环芳基等；而R2至R4、P1和Q代表卤素原子、氰基或类似物。

  公开号：

  US20070179115A1
• 作为产物：
  描述：

  香草醛 在 potassium phosphate 、 (1,1'-双(二苯基膦)二茂铁)二氯化镍 、 potassium hydroxide 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 24.0h， 生成 2-methoxy-[1,1'-biphenyl]-4-carbaldehyde
  参考文献：
  名称：

  镍催化杂芳基醚与芳基硼酸的铃木-宫浦偶联

  摘要：

  镍催化杂芳基醚与芳基硼酸的铃木-宫浦偶合。苯酚C-O键的选择性活化是通过将其转化为相应的芳基2,4-二甲氧基-1,3,5-三嗪-6-基醚来实现的，其中芳基C-O键可以用廉价的方法选择性裂解。 ，空气稳定的NiCl 2（dppf）作为催化剂。这些易于获得的杂芳基醚的偶联被证明对广泛的官能团具有耐受性。

  DOI：

  10.1021/jo4005537

文献信息

• The First General Palladium Catalyst for the Suzuki−Miyaura and Carbonyl Enolate Coupling of Aryl Arenesulfonates
  作者：Hanh Nho Nguyen、Xiaohua Huang、Stephen L. Buchwald

  DOI：10.1021/ja036947t

  日期：2003.10.1

  for the palladium-catalyzed Suzuki-Miyaura and carbonyl enolate coupling of unactivated aryl arenesulfonates was developed utilizing XPhos, 1, and Pd(OAc)2. This is of significant interest because aryl tosylates and aryl benzenesulfonates are more easily handled and considerably less expensive than aryl triflates. This catalyst system effects the coupling of a variety of aryl, heteroaryl, and extremely

  利用 XPhos、1 和 Pd(OAc)2 开发了钯催化的 Suzuki-Miyaura 和未活化芳基芳烃磺酸酯羰基烯醇化物偶联的第一种通用方法。这是非常有趣的，因为芳基甲苯磺酸酯和芳基苯磺酸酯比芳基三氟甲磺酸酯更容易处理且成本低得多。该催化剂体系在温和条件下实现了多种芳基、杂芳基和受阻极强的芳基硼酸与不同的甲苯磺酸芳基酯的偶联。在芳基芳烃磺酸酯的第一次羰基烯醇化物偶联中使用相同的催化剂。
• 베타 아밀로이드의 올리고화 및 섬유화 저해능과 함께 신경세포 보호능력을 갖는 신규 알츠하이머병 치료제
  申请人：Konkuk University Industrial Cooperation Corp 건국대학교 산학협력단(220040157648) BRN ▼206-82-07325

  公开号：KR20170017173A

  公开（公告）日：2017-02-15

  본 발명은 베타 아밀로이드의 올리고화 및 섬유화 저해능과 함께 신경세포 보호능력을 갖는 신규 알츠하이머병 치료제 개발에 관한 것으로 본 발명의 화합물은 알쯔하이머병 치료효과를 유지한 채 기존의 커큐민의 특이적 활성인 올리고머 및 섬유형 아밀로이드베타의 직접적 저해능력을 회복시킴으로써 새로운 저해제로 사용될 수 있다.

  This invention relates to the development of a novel Alzheimer's disease treatment with the ability to inhibit the oligomerization and fibrillation of beta-amyloid, while also possessing neuroprotective capabilities. The compound of this invention can be used as a new inhibitor by restoring the specific activity of curcumin, while maintaining the therapeutic effect on Alzheimer's disease, directly inhibiting the oligomeric and fibrillar forms of beta-amyloid.
• Certain thiol inhibitors of endothelin-converting enzyme
  申请人：——

  公开号：US20020082218A1

  公开（公告）日：2002-06-27

  Disclosed as endothelin converting enzyme inhibitors are the compounds of the formula 1 wherein the variables have the meanings as defined hereinbefore.

  披露的内皮素转化酶抑制剂是具有以下公式的化合物，其中变量的含义如前文所定义。
• Nickel-catalyzed one-pot synthesis of biaryls from phenols and arylboronic acids via C–O activation using TCT reagent
  作者：Nasser Iranpoor、Farhad Panahi、Fereshteh Jamedi

  DOI：10.1016/j.jorganchem.2015.01.009

  日期：2015.4

  In this study, the direct Nickel-catalyzed Suzuki–Miyaura coupling reaction of phenols and arylboronic acids via C–O bond activation using 2,4,6-trichloro-1,3,5-triazine (TCT) is described. Initially, phenols were reacted with TCT to give the corresponding 2,4,6-triaryloxy-1,3,5-triazine (TAT) products. Subsequently, arylboronic acid, base and Ni-catalyst were added to the generated aryl C–O electrophile

  在这项研究中，描述了使用2,4,6-三氯-1,3,5-三嗪（TCT）通过C–O键活化的酚和芳基硼酸的直接镍催化Suzuki–Miyaura偶联反应。最初，苯酚与TCT反应，得到相应的2,4,6-三芳氧基-1,3,5-三嗪（TAT）产物。随后，将芳基硼酸，碱和Ni催化剂添加到生成的芳基C-O亲电试剂中，以获得最终的联芳基产物。这项研究代表了一种简单直接的方法，使用亚化学当量的TCT作为廉价且容易获得的C–O活化剂，从酚类化合物合成联芳基。
• Nickel-Catalyzed Suzuki–Miyaura Coupling of Heteroaryl Ethers with Arylboronic Acids
  作者：Xiao-Jian Li、Jin-Ling Zhang、Yu Geng、Zhong Jin

  DOI：10.1021/jo4005537

  日期：2013.5.17

  Nickel-catalyzed Suzuki–Miyaura coupling of heteroaryl ethers with arylboronic acids was described. Selective activation of the phenol C–O bonds was achieved by converting them into the corresponding aryl 2,4-dimethoxy-1,3,5-triazine-6-yl ethers, in which aryl C–O bond could be selectively cleaved with inexpensive, air-stable NiCl2(dppf) as a catalyst. Coupling of these readily accessible heteroaryl

  镍催化杂芳基醚与芳基硼酸的铃木-宫浦偶合。苯酚C-O键的选择性活化是通过将其转化为相应的芳基2,4-二甲氧基-1,3,5-三嗪-6-基醚来实现的，其中芳基C-O键可以用廉价的方法选择性裂解。 ，空气稳定的NiCl 2（dppf）作为催化剂。这些易于获得的杂芳基醚的偶联被证明对广泛的官能团具有耐受性。