2-(N,N-Dimethylaminomethylene)indolin-3-one | 133593-42-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(N,N-Dimethylaminomethylene)indolin-3-one
• 英文别名: 2-[(dimethylamino)methylene]-1,2-dihydro-3H-indol-3-one；(2E)-2-(dimethylaminomethylidene)-1H-indol-3-one
• CAS: 133593-42-7
• 化学式: C₁₁H₁₂N₂O
• 分子量: 188.229
• InChiKey: JBUIWRKRAAXHNB-JXMROGBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(N,N-Dimethylaminomethylene)indolin-3-one 在 水 作用下， 生成 2-Formyl-3-acetoxyindole
  参考文献：
  名称：

  Lactam and acid amide acetals. 64. Acylation of enamino ketones of the indolin-3-one and 2-pyrrolin-4-one series and synthesis of 2-indolyl- and 5-pyrrolylacrylic acid derivatives

  摘要：

  DOI：

  10.1007/bf00474229

文献信息

• Synthesis and reactivity of 2-formylindole and 5-formylpyrrole derivatives
  作者：S. Yu. Ryabova、Yu. I. Trofimkin、V. A. Azimov、L. M. Alekseeva、V. G. Granik

  DOI：10.1007/bf02226525

  日期：1995.2

  The methylation of 2-formyl-3-hydroxyindole was studied, and the sequence of introduction the methyl groups was traced by1H NMR spectroscopy. The O-methyl, N-methyl, and N,O-methyl derivatives of 2-formylindole, and also the O-methyl and N-methyl derivatives of 2-methyl-3-ethoxycarbonyl-4-hydroxypyrrole were synthesized. Novel derivatives of indolyl- and pyrrolylacrylic acids were obtained on the basis

  研究了2-甲酰基-3-羟基吲哚的甲基化反应，并通过1H NMR谱追踪了甲基的引入顺序。合成了2-甲酰基吲哚的O-甲基、N-甲基和N,O-甲基衍生物，以及2-甲基-3-乙氧基羰基-4-羟基吡咯的O-甲基和N-甲基衍生物。在吲哚和吡咯系列的一些 O-和 N,O-取代醛的基础上，获得了吲哚基丙烯酸和吡咯基丙烯酸的新型衍生物。
• NOVEL ANTITHROMBOTIC AND ANTIATHEROSCLEROTIC AGENT AND METHOD FOR PRODUCING SAME (VARIANTS)
  申请人：Proton OOO

  公开号：US20140235868A1

  公开（公告）日：2014-08-21

  The invention relates to the field of chemical and pharmaceutical industry and medicine and concerns compounds which can be used to produce agents for the treatment of cardiovascular diseases. The use of 2-[2-cyano-2-[5-(hydroxymethyl)-3-methyl-1,3-oxazolidin-2-ylidene]ethylidene]indolin-3-one of formula I is proposed as a biologically active compound exhibiting the properties of exogenous nitric oxide donor, a platelet aggregation inhibitor, also exhibiting antihypertensive activity and activating activity towards the soluble guanylate cyclase enzyme. Variants of methods for synthesizing the above compound are also proposed.

  本发明涉及化学和制药工业以及医药学领域，涉及可用于制造治疗心血管疾病制剂的化合物。建议使用式I的2-[2-氰基-2-[5-(羟甲基)-3-甲基-1,3-噁唑烷-2-基]乙烯基]吲哚啉-3-酮作为生物活性化合物，具有外源性一氧化氮供体的特性，是血小板聚集抑制剂，还具有降压活性和活化可溶性鸟苷酸环化酶酶的活性。还提出了合成上述化合物的方法变体。
• Synthesis and testing of antiviral activity of azaheterocycles with hydroxyl-containing fragments as substituents
  作者：S. Yu. Ryabova、Yu. I. Trofimkin、N. Z. Tugusheva、A. V. Kadushkin、I. S. Nikolaeva、T. A. Gus'kova、N. I. Fadeeva、I. A. Leneva、V. G. Granik

  DOI：10.1007/bf00780586

  日期：1993.9
• US9453008B2
  申请人：——

  公开号：US9453008B2

  公开（公告）日：2016-09-27
• Lactam and acid amide acetals. 64. Acylation of enamino ketones of the indolin-3-one and 2-pyrrolin-4-one series and synthesis of 2-indolyl- and 5-pyrrolylacrylic acid derivatives
  作者：S. Yu. Ryabova、Yu. I. Trofimkin、L. M. Alekseeva、L. S. Khabarova、V. G. Granik

  DOI：10.1007/bf00474229

  日期：1991.3