N-(2-amino-4-hydroxyphenyl)acetamide | 67694-84-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-amino-4-hydroxyphenyl)acetamide
• 英文别名: acetic acid-(2-amino-4-hydroxy-anilide)；Essigsaeure-(2-amino-4-hydroxy-anilid)；3-Amino-4-acetamino-phenol
• CAS: 67694-84-2
• 化学式: C₈H₁₀N₂O₂
• 分子量: 166.18
• InChiKey: QSFRZMKFIHSITE-UHFFFAOYSA-N

物化性质

• 熔点：
  191 °C
• 沸点：
  443.5±35.0 °C(Predicted)
• 密度：
  1.348±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  75.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(2-amino-4-hydroxyphenyl)acetamide 生成 1-hydroxy-3,4-diacetamidobenzene
  参考文献：
  名称：

  Derivatives of N¹-Phenylsulfanilamide. II

  摘要：

  DOI：

  10.1021/ja01852a036
• 作为产物：
  描述：

  N-乙酰苯胺 在 palladium 10% on activated carbon 、 三氟化硼乙醚 、 硝酸 、 溶剂黄146 、 [双(三氟乙酰氧基)碘]苯 作用下， 以 水 为溶剂， 反应 2.5h， 生成 N-(2-amino-4-hydroxyphenyl)acetamide
  参考文献：
  名称：

  Acylamino-Directed Specific Sequential Difunctionalizations of Anilides via Metal-Free Relay Reactions for p-Oxygen and o-Nitrogen Incorporation

  摘要：

  Novel acylamino-directed relay disubstitutions realize the sequential difunctionalizations of anilides (1) under mild and metal-free conditions for the first time. This [bis(trifluoroacetoxy)iodo]benzene (PIFA) and BF3 center dot Et2O promoted straightforward reaction produces a series of p-acetoxyl- or p-alkoxyl-o-nitro-N-arylamides (2), which are key scaffolds of various drugs, functional materials, and bioactive molecules. The flexibility with respect to the functional groups in these products affords this novel protocol excellent versatility for synthetic applications.

  DOI：

  10.1021/acs.joc.8b02636

文献信息

• Rapid one-pot preparation of 2-substituted benzimidazoles from 2-nitroanilines using microwave conditions
  作者：David S. VanVliet、Paul Gillespie、Jan J. Scicinski

  DOI：10.1016/j.tetlet.2005.07.130

  日期：2005.9

  A high yielding one-pot procedure for the generation of 2-substituted benzimidazoles directly from 2-nitroanilines by in situ reduction and cyclization using a microwave procedure is described.

  描述了一种高产率的一锅法，该方法通过微波还原法原位还原和环化直接从2-硝基苯胺生成2-取代的苯并咪唑。
• O-pyridinequinone derivatives, the composition containing the derivatives, the process for preparation of the derivatives and the use of the derivatives
  申请人：Gu Lianquan

  公开号：US20060111405A1

  公开（公告）日：2006-05-25

  The present invention relates to the o-pyridinequinone disubstituted derivatives, the composition containing the derivatives, the process for preparation of the derivatives and the use of the derivatives. The o-pyridinequinone disubstituted derivatives of the present invention have action of selectivity inhibiting COX-2 and they can be made into pharmaceuticals. The o-pyridinequinone disubstituted derivatives of the present invention have no acute toxicities and are a safe pharmaceutical.

  本发明涉及o-吡啶醌二取代衍生物、含有该衍生物的组合物、制备该衍生物的过程以及该衍生物的用途。本发明的o-吡啶醌二取代衍生物具有选择性抑制COX-2的作用，可制成药物。本发明的o-吡啶醌二取代衍生物无急性毒性，是一种安全的药物。
• CCCLVII.—The amino-1-methylbenzoxazoles and their conversion into the arsinic acids of o-aminophenol
  作者：Montague Alexandra Phillips

  DOI：10.1039/jr9300002685

  日期：——
• US7547713B2
  申请人：——

  公开号：US7547713B2

  公开（公告）日：2009-06-16
• Derivatives of N¹-Phenylsulfanilamide. II
  作者：G. L. Webster、S. D. Gershon

  DOI：10.1021/ja01852a036

  日期：1941.7