N-Methyl-2-(propylthio)acetamide | 87122-88-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Methyl-2-(propylthio)acetamide
• 英文别名: N-methyl-2-propylsulfanylacetamide
• CAS: 87122-88-1
• 化学式: C₆H₁₃NOS
• mdl: MFCD19159830
• 分子量: 147.241
• InChiKey: ORMDTLASJOJVOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (丙基硫代)乙酸 在 氯化亚砜 作用下， 以 苯 为溶剂， 反应 3.08h， 生成 N-Methyl-2-(propylthio)acetamide
  参考文献：
  名称：

  Mori, Yuji; Fujiwara, Shigeru; Miyachi, Toshiko, Chemical and pharmaceutical bulletin, 1983, vol. 31, # 5, p. 1505 - 1517

  摘要：

  DOI：

文献信息

• AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS
  申请人：ECOLE NORMALE SUPERIEURE DE LYON

  公开号：US20170051149A1

  公开（公告）日：2017-02-23

  The invention concerns a new class of tubulin polymerisation inhibitors and their applications in research and medicine, notably in chemotherapy. The invention proposes new azoaryl derivatives of formula (I): as defined in Claim 1 , which may be fully reversibly interconverted between non-tubulin-binding trans and tubulin-binding as isomeric forms, either by irradiation or spontaneously. The invention also concerns compounds with a azoaryl structure for use in studying the cytoskeleton and/or its associated processes, or in the treatment of a disease for which a tubulin polymerisation inhibition activity has a beneficial effect, wherein the compound is administered to the cell, organism or patient in need of such treatment in the trans form of the diazenyl bond, and where this trans form is inactive as regards a tubulin polymerisation inhibition effect, and where after photoisomerisation in vitro, in cellulo or in vivo to an azoaryl compound in its cis isomeric form of the diazenyl bond by the application of light, optionally with modification in vitro, in cellulo or in vivo of one or more substituents, the resultant cis form is active as regards a tubulin polymerisation inhibition effect.
• Mori, Yuji; Fujiwara, Shigeru; Miyachi, Toshiko, Chemical and pharmaceutical bulletin, 1983, vol. 31, # 5, p. 1505 - 1517
  作者：Mori, Yuji、Fujiwara, Shigeru、Miyachi, Toshiko、Kitanishi, Hiroyuki、Oya, Masayuki、et al.

  DOI：——

  日期：——