(rac)-N-Benzoyltyrosin-ethylester | 56598-65-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (rac)-N-Benzoyltyrosin-ethylester
• 英文别名: N-benzoyl tyrosine ethyl ester；N-benzoyl-tyrosine-ethyl ester；N-benzoyltyrosine ethyl ether；N-benzoyl-DL-tyrosine ethyl ester；N-benzoyl-tyrosine ethyl ester；N-Benzoyl-DL-tyrosin-aethylester；Ethyl 2-benzamido-3-(4-hydroxyphenyl)propanoate
• CAS: 56598-65-3
• 化学式: C₁₈H₁₉NO₄
• 分子量: 313.353
• InChiKey: SRLROPAFMUDDRC-UHFFFAOYSA-N

物化性质

• 沸点：
  557.3±45.0 °C(Predicted)
• 密度：
  1.210±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (rac)-N-Benzoyltyrosin-ethylester 生成 N-苯甲酰-L-酪氨酸乙酯
  参考文献：
  名称：

  Blaschke, Gottfried; Kraft, Horst Peter; Markgraf, Hildegunde, Chemische Berichte, 1983, vol. 116, # 11, p. 3611 - 3617

  摘要：

  DOI：
• 作为产物：
  描述：

  乙醇 、 alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 作用下， 生成 (rac)-N-Benzoyltyrosin-ethylester
  参考文献：
  名称：

  Curtius, Journal fur praktische Chemie (Leipzig 1954), 1917, vol. <2> 95, p. 341

  摘要：

  DOI：

文献信息

• METHOD OF PREDICTING SPOT FORMATION ON THE SKIN WITH THE USE OF SPOT SITE-ACCELERATING GENES AS INDICATION AND METHOD OF SCREENING INHIBITOR FOR SPOT FORMATION ON THE SKIN
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP1691199A1

  公开（公告）日：2006-08-16

  The present invention provides a skin test method for predicting the formation of spots in the skin. This method judges skin to be susceptible to the formation of spots in the case expression in the epidermis of MCP-2 gene, a polynucleotide capable of hybridizing under highly stringent conditions to mouse AK012157 gene, human FLJ21763 gene or rat S74257 gene, or Mcp9, Mcp10, Isg15, Usp18, Oas12, Gbp2, Gtpi, Ifi47, Igtp, Tgtp, Sprr2A, Krt2-6b, Cdk5rap2, Mef2C, Gsta4, Osf2, Tnc, Igfbp6, Ppicap or Mm. 74656 gene, is increased as compared with normal expression in the epidermis.

  本发明提供了一种预测皮肤斑点形成的皮肤测试方法。该方法判断皮肤在表皮中表达 MCP-2 基因的情况下容易形成斑点，MCP-2 基因是一种多核苷酸，能在高度严格的条件下与小鼠 AK012157 基因、人类 FLJ21763 基因或大鼠 S74257 基因、或 Mcp9、Mcp10、Isg15、Usp15 基因杂交、人 FLJ21763 基因或大鼠 S74257 基因，或 Mcp9、Mcp10、Isg15、Usp18、Oas12、Gbp2、Gtpi、Ifi47、Igtp、Tgtp、Sprr2A、Krt2-6b、Cdk5rap2、Mef2C、Gsta4、Osf2、Tnc、Igfbp6、Ppicap 或 Mm.与表皮中的正常表达量相比，74656 基因的表达量有所增加。
• Novel thermostable proteolytic enzymes and uses thereof in peptide and protein synthesis
  申请人：——

  公开号：US20030170867A1

  公开（公告）日：2003-09-11

  The subject invention pertains to new thermostable enzymes and the use of these enzymes both in proteolysis as well as protein and polypeptide synthesis. The subject invention further concerns polynucleotide sequences which encode the enzymes of the subject invention.

  本发明涉及新的恒温酶和这些酶在蛋白质分解以及蛋白质和多肽合成中的用途。 本发明还涉及编码本发明酶的多核苷酸序列。
• Curtius, Journal fur praktische Chemie (Leipzig 1954), 1917, vol. <2> 95, p. 341
  作者：Curtius

  DOI：——

  日期：——
• Zahn et al., Chemische Berichte, 1956, vol. 89, p. 407,414
  作者：Zahn et al.

  DOI：——

  日期：——
• Coordination modes of aminoacids to zinc
  作者：M. Rombach、M. Gelinsky、H. Vahrenkamp

  DOI：10.1016/s0020-1693(02)00748-x

  日期：2002.5

  Two new binary zinc-aminoacid complexes were crystallized: Zn(Ile)(2)(H2O)(2) is octahedral with two O,N-chelating aminoacid ligands; Zn(Phe)(2) is a one-dimensional coordination polymer with eta(2)-carboxylate bridges. The pyrazolylborate zinc complex Tp(Ph,Me)Zn-OH reacted with simple aminoacids to form the complexes Tp(Ph,Me)Zn-AA (AA = Gly, Val, Leu, Met, Phe, Trp) in which AA is a O,N-chelate ligand. In a similar fashion aminoacid-nitroanilides were deprotonated at the N atom yielding the Tp(Ph),Zn-Me complexes with the N,N-chelating ligands Gly-Nit, Ala-Nit and Leu-Nit. When terminal amino functions were missing, pure carboxylate coordination resulted, as in Tp(Ph,Me)Zn-GlyPheBoc and Tp(Ph,Me)Zn-AspPheOMe. Exclusive side-chain coordination was enforced in Bz-Tyr-OEt resulting in the Tp(Ph,Me)Zn complex with the phenolate-bound aminoacid. Combinations of the binding types (O,N-chelate+carboxylate, O,N-chelate+phenolate, O,N-chelate+thiolate) were realized in the binuclear complexes Tp(Ph,Me)Zn-AA-ZnTp(Ph,Me) for AA = Asp, Glu, Tyr and Cys. (C) 2002 Elsevier Science B.V. All rights reserved.

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