2,2-dimethyl-3-<3,4-(methylenedioxy)phenyl>propionic acid | 54508-53-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 2,2-dimethyl-3-<3,4-(methylenedioxy)phenyl>propionic acid
• 英文别名: 3-(1,3-Benzodioxol-5-yl)-2,2-dimethylpropanoic acid
• CAS: 54508-53-1
• 化学式: C₁₂H₁₄O₄
• 分子量: 222.241
• InChiKey: YBSYDWKUFXNBPX-UHFFFAOYSA-N

物化性质

• 沸点：
  355.5±11.0 °C(Predicted)
• 密度：
  1.251±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,2-dimethyl-3-<3,4-(methylenedioxy)phenyl>propionic acid 在 sodium azide 、 氢气 、 三乙胺 作用下， 以 乙醇 、 水 、 丙酮 、 甲苯 为溶剂， 25.0 ℃ 、241.32 kPa 条件下， 反应 25.25h， 生成 1-(3,4-methylenedioxyphenyl)-2-methyl-2-(R/S)-aminopropane
  参考文献：
  名称：

  Effects of certain hallucinogenic amphetamine analogs on the release of [3H]-serotonin from rat brain synaptosomes

  摘要：

  The enantiomers of 3,4-(methylenedioxy)amphetamine (MDA), p-methoxyamphetamine (PMA), and N-Me-MDA (MDMA), along with their alpha, alpha-dimethylated derivatives, were evaluated for an effect on the release of [3H]serotonin from rat whole brain synaptosomes. The amphetamine isomers were all potent in inducing the release of [3H]serotonin at bath concentrations of 1 and 10 micrometers but were inactive at 0.1 micrometers. No significant difference in isomer potency was observed at the 10 micrometers concentration. However, at 1 micrometer the (+) isomer of MDMA was more effective in inducing release than was the (-) isomer. Since it is the (+) isomer which is clinically active, this result suggests that transmitter release may play a role in the biological activity of MDMA. By contrast, the alpha, alpha-dimethyl compounds were not effective in releasing serotonin, even at the highest bath concentration.

  DOI：

  10.1021/jm00347a010
• 作为产物：
  描述：

  胡椒基氯 、 异丁酸 在 六甲基磷酰三胺 、 lithium diisopropyl amide 作用下， 生成 2,2-dimethyl-3-<3,4-(methylenedioxy)phenyl>propionic acid
  参考文献：
  名称：

  Effects of certain hallucinogenic amphetamine analogs on the release of [3H]-serotonin from rat brain synaptosomes

  摘要：

  The enantiomers of 3,4-(methylenedioxy)amphetamine (MDA), p-methoxyamphetamine (PMA), and N-Me-MDA (MDMA), along with their alpha, alpha-dimethylated derivatives, were evaluated for an effect on the release of [3H]serotonin from rat whole brain synaptosomes. The amphetamine isomers were all potent in inducing the release of [3H]serotonin at bath concentrations of 1 and 10 micrometers but were inactive at 0.1 micrometers. No significant difference in isomer potency was observed at the 10 micrometers concentration. However, at 1 micrometer the (+) isomer of MDMA was more effective in inducing release than was the (-) isomer. Since it is the (+) isomer which is clinically active, this result suggests that transmitter release may play a role in the biological activity of MDMA. By contrast, the alpha, alpha-dimethyl compounds were not effective in releasing serotonin, even at the highest bath concentration.

  DOI：

  10.1021/jm00347a010

文献信息

• Mittel zur Bekämpfung von Hausstaubmilben zusammen mit anderen Kleinschädlingen und/oder Pilzen
  申请人：Werner & Mertz GmbH

  公开号：EP0247287A1

  公开（公告）日：1987-12-02

  Die Erfindung betrifft ein Mittel zur Abtötung von Hausstaubmilben auf der Basis einer überwiegend wäßrigen Trägerflüssigkeit sowie dessen Verwendung, wobei gleichzeitig auch andere Kleinschädlinge und/oder Pilze bekämpft werden.

  本发明涉及一种主要以水性载液为基础的杀灭室内尘螨的药剂及其使用方法，可同时消灭其他小型害虫和/或真菌。
• ADDITIVE MANUFACTURING OF A CHOCOLATE FOOD PRODUCT
  申请人：Chocoladefabriken Lindt & Sprüngli GmbH

  公开号：EP3715118A1

  公开（公告）日：2020-09-30

  An additive manufacturing (100) apparatus for manufacturing a food product from a chocolate, milk and/or cocoa composition is provided. The apparatus comprises a storage container (102) at least partially filled with a chocolate powder; a building container (106); at least one controller (110); a wiper (112) configured to convey an amount (114) of the chocolate powder from the storage container (102) to the building container (106) to form a printing layer (116) of the chocolate powder; an application system (118) configured to apply a binder material, which comprises at least cocoa butter, to the printing layer. Therein, the controller (110) is configured to control at least one of a movement of the application system (118), a temperature of the binder material, and at least one valve (124) of the application system, such that the binder material (126) is kept in a flowable condition and applied to the printing layer (116).

  提供了一种用于用巧克力、牛奶和/或可可组合物制造食品的添加剂制造（100）设备。该设备包括至少部分填充有巧克力粉末的存储容器 (102)；构建容器 (106)；至少一个控制器 (110)；刮水器 (112)，配置为将一定量的巧克力粉末 (114) 从存储容器 (102) 输送到构建容器 (106)，以形成巧克力粉末的印刷层 (116)；涂抹系统 (118)，配置为将至少包括可可脂的粘合剂材料涂抹到印刷层。其中，控制器 (110) 被配置为控制应用系统 (118) 的运动、粘合剂材料的温度和应用系统的至少一个阀门 (124) 中的至少一个，从而使粘合剂材料 (126) 保持在可流动状态并应用到印刷层 (116) 上。
• ACTIVE INGREDIENT-RELEASING CYCLIC SILOXANES
  申请人：General Electric Company

  公开号：EP1697386B1

  公开（公告）日：2007-10-10
• BICYCLIC SILOXANE COMPOSITIONS FOR THE RELEASE OF ACTIVE INGREDIENTS
  申请人：Momentive Performance Materials Inc.

  公开号：EP1716159B1

  公开（公告）日：2011-07-13
• VERBRAUCHSPRODUKTE MIT DUFTVIELFALT
  申请人：Henkel AG & Co. KGaA

  公开号：EP1928992A1

  公开（公告）日：2008-06-11