N-(benzo[d][1,3]dioxol-5-ylmethyl)-2,4,4-trimethylpentan-2-amine | 866815-94-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: N-(benzo[d][1,3]dioxol-5-ylmethyl)-2,4,4-trimethylpentan-2-amine
• 英文别名: N-(1,3-benzodioxol-5-ylmethyl)-2,4,4-trimethylpentan-2-amine
• CAS: 866815-94-3
• 化学式: C₁₆H₂₅NO₂
• 分子量: 263.38
• InChiKey: ZUVZCSDROMMRSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  胡椒醇 、 叔辛胺 在 palladium on aluminium oxyhydroxide 、 氢气 作用下， 以 正庚烷 为溶剂， 25.0~90.0 ℃ 、101.33 kPa 条件下， 反应 26.0h， 以84%的产率得到N-(benzo[d][1,3]dioxol-5-ylmethyl)-2,4,4-trimethylpentan-2-amine
  参考文献：
  名称：

  One-Pot Synthesis of Imines and Secondary Amines by Pd-Catalyzed Coupling of Benzyl Alcohols and Primary Amines

  摘要：

  Imines and secondary amines were synthesized selectively by controlling reaction conditions for the Pd-catalyzed one-pot reactions of benzyl alcohols with primary amines. The reactions did not require any additives and were effective for a wide range of alcohols and amines.

  DOI：

  10.1021/jo8026609

文献信息

• One-Pot Synthesis of Imines and Secondary Amines by Pd-Catalyzed Coupling of Benzyl Alcohols and Primary Amines
  作者：Min Serk Kwon、Sungjin Kim、Sungho Park、William Bosco、Ravi Kumar Chidrala、Jaiwook Park

  DOI：10.1021/jo8026609

  日期：2009.4.3

  Imines and secondary amines were synthesized selectively by controlling reaction conditions for the Pd-catalyzed one-pot reactions of benzyl alcohols with primary amines. The reactions did not require any additives and were effective for a wide range of alcohols and amines.