2-iso-Butyloxy-tetrahydrofuran | 62987-02-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 2-iso-Butyloxy-tetrahydrofuran
• 英文别名: 2-Isobutoxytetrahydrofuran；2-(2-methylpropoxy)oxolane
• CAS: 62987-02-4
• 化学式: C₈H₁₆O₂
• 分子量: 144.214
• InChiKey: FYQNNTBRSOJZTM-UHFFFAOYSA-N

物化性质

• 沸点：
  152-155 °C
• 密度：
  0.92±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  四氢呋喃 、 异丁醇 在 Amberlyst-15 、 air 作用下， 以30%的产率得到2-iso-Butyloxy-tetrahydrofuran
  参考文献：
  名称：

  Amberlyst-15-Catalyzed One-Pot Synthesis of 2-Aryltetrahydrofurans from Tetrahydrofuran

  摘要：

  A simple one-step route for the conversion of naphthols and phenols with tetrahydrofuran into corresponding 2-aryltetrahydrofurans using Amberlyst-15 as a catalyst is reported. This is the first example of the acid-mediated formation and rearrangement reactions of tetrahydrofuranyl ethers prepared from the tetrahydrofuran and aromatic/aliphatic hydroxy compounds.

  DOI：

  10.1055/s-0032-1317195

文献信息

• Indazole Ureas and Method of Use
  申请人：AbbVie Inc.

  公开号：US20160075692A1

  公开（公告）日：2016-03-17

  Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein A, R 1 and R 2 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Na v 1.7 and/or Na v 1.8. Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

  化合物的化学式（I）及其药用可接受的盐、酯、酰胺或放射标记形式，其中A、R1和R2如规范中所定义，可用于治疗由电压门控钠通道如Na v 1.7和/或Na v 1.8预防或改善的疾病或疾病。公开了制备这些化合物的方法。还公开了化合物的药物组合物，以及使用这些化合物和组合物的方法。
• Process for the preparation of 2-alkoxytetrahydrofurans via
  申请人：General Electric Company

  公开号：US04139542A1

  公开（公告）日：1979-02-13

  2-Alkoxytetrahydrofurans are prepared in higher yields when an allylic alcohol is hydroformylated in the presence of an alkanol and a rhodium/tertiaryphosphine-complex if an acid co-catalyst is used. The products are useful, inter alia, as intermediates in the preparation of butanediols and substituted derivatives thereof.

  当烯丙醇在存在一种烷醇和一种铑/三膦复合物以及一种酸协同催化剂的情况下进行羟甲基化反应时，制备2-烷氧基四氢呋喃的收率更高。该产品可用作丁二醇及其取代衍生物的制备中间体。
• US4139542A
  申请人：——

  公开号：US4139542A

  公开（公告）日：1979-02-13
• US9783527B2
  申请人：——

  公开号：US9783527B2

  公开（公告）日：2017-10-10
• Amberlyst-15-Catalyzed One-Pot Synthesis of 2-Aryltetrahydrofurans from Tetrahydrofuran
  作者：Naciye Talinli、Hande Gunduz、Volkan Kumbaraci

  DOI：10.1055/s-0032-1317195

  日期：——

  A simple one-step route for the conversion of naphthols and phenols with tetrahydrofuran into corresponding 2-aryltetrahydrofurans using Amberlyst-15 as a catalyst is reported. This is the first example of the acid-mediated formation and rearrangement reactions of tetrahydrofuranyl ethers prepared from the tetrahydrofuran and aromatic/aliphatic hydroxy compounds.