1-[3-(4-methylphenoxy)-2-hydroxypropyl]piperazine | 883546-08-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-[3-(4-methylphenoxy)-2-hydroxypropyl]piperazine
• 英文别名: 1-Piperazin-1-yl-3-p-tolyloxy-propan-2-ol；1-(4-methylphenoxy)-3-piperazin-1-ylpropan-2-ol
• CAS: 883546-08-5
• 化学式: C₁₄H₂₂N₂O₂
• mdl: MFCD07186460
• 分子量: 250.341
• InChiKey: XVLAXWBXNMSNFV-UHFFFAOYSA-N

物化性质

• 沸点：
  419.7±45.0 °C(Predicted)
• 密度：
  1.087±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  44.7
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 1-[3-(4-methylphenoxy)-2-hydroxypropyl]piperazine 、 N-炔丙基吩噻嗪 在 copper(II) sulfate 作用下， 以 乙醇 、 水 为溶剂， 反应 24.0h， 生成 1-[4-(4-phenothiazin-10-yl-but-2-ynyl)piperazin-1-yl]-3-p-tolyloxy-propan-2-ol
  参考文献：
  名称：

  Multidrug resistance reverting activity and antitumor profile of new phenothiazine derivatives

  摘要：

  A series of easily affordable phenothiazine derivatives bearing a rigid but-2-ynyl amino side chain were synthesized and tested to evaluate the MDR reverting activity and full antitumor pro. le. Some compounds endowed with remarkable MDR reverting effect were identified, and the most active one (6c) was shown to increase doxorubicin retention in multidrug resistant cells, suggesting a direct interaction with P-glycoprotein. Furthermore, a broad range of cellular activities were observed for different compounds. In particular, the ability of some derivatives to induce antiproliferative effects on resistant cell lines and to interfere with the G(1) phase of the cell cycle, a phase usually not affected by classical antitumor agents, was noted. Moreover, the most cytotoxic compounds of the series were able to induce apoptosis in resistant cell lines, via an atypical pathway of caspase cascade activation, and a synergistic effect in combination with doxorubicin was also found. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.05.040

文献信息

• DERIVATIVES OF 1-PHENOXY PROPAN-2-OL AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
  申请人：KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

  公开号：US20150166496A1

  公开（公告）日：2015-06-18

  The present invention relates to a novel phenoxypropanol derivative, use thereof for blocking T-type calcium channel and/or TREK channel, and use thereof for preventing and/or treating T-type calcium channel- and/or TREK channel-associated diseases.

  本发明涉及一种新型苯氧丙醇衍生物，其用于阻断T型钙通道和/或TREK通道，以及其用于预防和/或治疗与T型钙通道和/或TREK通道相关的疾病。
• Cardioselective aryloxy- and arylthio-hydroxypropyl piperazinyl acetanilides wich affect calcium entry
  申请人：SYNTEX (U.S.A.) INC.

  公开号：EP0126449A1

  公开（公告）日：1984-11-28

  Novel compounds of the general formula and the pharmaceutically acceptable esters and acid addition salts thereof, wherein: R1, R2, R3, R4, and R5 are each independently hydrogen, lower alkyl, lower alkoxy, cyano, trifluoromethyl, halo, lower alkylthio, lower alkyl sulfinyl, lower alkyl sulfonyl, N-optionally substituted alkylamido, except that when R1 is methyl, R4 is not methyl; or R2 and R3 together form -OCH2O-; R6, R7, R8, R9 and R10 are each independently hydrogen, lower acyl, aminocarbonyl-methyl, arylcyano, lower alkyl, lower alkoxy, trifluoromethyl, halo, lower alkylthio, lower alkyl sulfinyl, lower alkyl sulfonyl, di-lower alkyl amino; or R6 and R7 together form -CH = CH-CH = CH-; R7 and R8 together form -OCH2O -; R11 and R12 are each independently hydrogen or lower alkyl; and W is oxygen or sulfur. These cardioselective compounds have calcium entry blockade properties and therefore are useful in therapy in the treatment of cardiovascular diseases, including arrhythmias, variant and exercise induced angina and myocardial infarction.

  通式为 及其药学上可接受的酯和酸加成盐，其中 R1、R2、R3、R4 和 R5 各自独立地为氢、低级烷基、低级烷氧基、氰基、三氟甲基、卤代、低级烷硫基、低级烷基亚磺酰基、低级烷基磺酰基、N-可选取代的烷基氨基，但当 R1 为甲基时，R4 不是甲基；或 R2 和 R3 共同形成 -OCH2O-； R6、R7、R8、R9 和 R10 各自独立地为氢、低级酰基、氨基羰基甲基、芳基氰基、低级烷基、低级烷氧基、三氟甲基、卤代、低级烷硫基、低级烷基亚磺酰基、低级烷基磺酰基、二低级烷基氨基；或 R6 和 R7 共同形成 -CH = CH-CH = CH-； R7 和 R8 共同形成 -OCH2O -； R11 和 R12 各自独立地为氢或低级烷基；以及 W 是氧或硫。 这些心脏选择性化合物具有钙离子进入阻断特性，因此可用于治疗心血管疾病，包括心律失常、变异型和运动诱发的心绞痛和心肌梗塞。
• Azomethine dye precursor, image-forming material, and image-forming method
  申请人：——

  公开号：US20010019806A1

  公开（公告）日：2001-09-06

  The present invention related to an azomethine dye precursor represented by the following general formula (1) and the image-forming material and image-forming method using the azomethine dye precursor: wherein Ar represents an aryl group or a heterocyclic group which may each have a substituent; X represents a bivalent group linking a carbon atom and a nitrogen atom; and Cp represent a coupler residue which may or may not form a ring. General formula 1

  本发明涉及由以下通式（1）表示的偶氮亚甲基染料前体以及使用该偶氮亚甲基染料前体的成象材料和成象方法： 其中 Ar 代表芳基或杂环基，它们可以各自具有一个取代基；X 代表连接碳原子和氮原子的二价基团；Cp 代表耦合剂残基，它可以形成环，也可以不形成环。 通式 1
• Guanidine compound and heat sensitive recording material
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：US20020065194A1

  公开（公告）日：2002-05-30

  An object of the present invention is to provide a heat sensitive recording material which can develop color at high density by the inclusion of a novel guanidine compound which is strongly basic and superior in diffusion resistance. The present invention for attaining the above-described object is a heat sensitive recording material comprising a substrate supporting thereon a heat sensitive recording layer containing a diazonium salt compound, a coupler which reacts with the diazonium salt compound when heated to develop color, and a base, wherein the heat sensitive recording layer includes as the base at least one of the guanidine compounds represented by the general formula (1): 1 , wherein, in the general formula (1), R 1 and R 2 represent an alkyl group or aryl group and may be the same or different, R 3 and R 4 represent a hydrogen atom, alkyl group or halogen atom and may be the same or different, and X represents a divalent connecting group.

  本发明的目的是提供一种热敏记录材料，通过加入一种新型胍化合物，该化合物具有强碱性和优越的抗扩散性，可在高密度下显色。为达到上述目的，本发明是一种热敏记录材料，它包括一个基片，基片上支撑着一个含有重氮盐化合物的热敏记录层，一个在加热时与重氮盐化合物反应而显色的耦合剂，以及一个碱基，其中热敏记录层包括至少一种由通式（1）表示的胍类化合物作为碱基： 1 其中，在通式（1）中，R 1 和 R 2 代表烷基或芳基，可以相同或不同，R 3 和 R 4 代表氢原子、烷基或卤素原子，可以相同或不同，X 代表二价连接基团。
• Phenylurethane compounds and methods for producing same, asymmetric urea compounds and methods for producing same, barbituric acid derivative, and diazo thermal recording material containing the derivative
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：US20030166961A1

  公开（公告）日：2003-09-04

  Phenylurethane compounds of the following general formula (1); asymmetric urea compounds of the following general formula (10) obtained from the phenylurethane compounds; barbituric acid derivatives of general formula (18) produced from the asymmetric urea compounds, which have specific substituents and are useful in diazo thermal recording materials; and diazo thermal recording materials containing the barbituric acid derivative. 1