N-phenyl-cis-2,3-dimethylsuccinimide | 6144-74-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-phenyl-cis-2,3-dimethylsuccinimide
• 英文别名: meso-cis-3,4-Dimethyl-N-phenyl-succinimid；cis-2,3-Dimethyl-N-phenylsuccinimid；(3S,4R)-3,4-dimethyl-1-phenyl-pyrrolidine-2,5-dione；(3R,4S)-3,4-dimethyl-1-phenylpyrrolidine-2,5-dione
• CAS: 6144-74-7
• 化学式: C₁₂H₁₃NO₂
• 分子量: 203.241
• InChiKey: XIVXEDQMZOROKE-DTORHVGOSA-N

物化性质

• 沸点：
  390.6±11.0 °C(Predicted)
• 密度：
  1.148±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-phenyl-cis-2,3-dimethylsuccinimide 在 鹰爪豆碱 作用下， 以 二甲基亚砜 为溶剂， 反应 192.0h， 生成 N-phenyl-trans-2,3-dimethylsuccinimide
  参考文献：
  名称：

  Asymmetric hydrogenation of the C–C double bond of 1- and 1,2-methylated maleimides with cultured suspension cells of Marchantia polymorpha

  摘要：

  Suspension cultured cells of Marchantia polymorpha have the potential to hydrogenate the C-C double bonds of 2-methyl- and 2,3-dimethylmaleimide derivatives to give enantiomerically pure (2R)-2-methyl- and (2R, 3R)-2, 3-dimethylsuccinimide derivatives, respectively. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.06.030
• 作为产物：
  描述：

  溴甲烷 、 2-甲基-N-苯基马来酰亚胺 在 偶氮二异丁腈 、 三正丁基氢锡 作用下， 以 甲苯 为溶剂， 生成 N-phenyl-cis-2,3-dimethylsuccinimide 、 N-phenyl-trans-2,3-dimethylsuccinimide
  参考文献：
  名称：

  Giese, Bernd; Farshchi, Hassan; Hartmanns, Joerg, Angewandte Chemie, 1991, vol. 103, # 5, p. 619 - 620

  摘要：

  DOI：

文献信息

• New Alkali Soluble Resin
  申请人：Loccufier Johan

  公开号：US20110247516A1

  公开（公告）日：2011-10-13

  An alkali soluble resin is disclosed comprising a first monomeric unit including at least one sulfonamide group and a second monomeric unit derived from the monomer according to the following structure (I) wherein R 1 represents a structural moiety comprising an ethylenically unsaturated polymerisable group; R 2 , R 3 and R 4 independently represent hydrogen, an optionally substituted alkyl, alkenyl, alkynyl, alkaryl, aralkyl, aryl or heteroaryl group or, the necessary atoms to form a five to eight membered ring.

  揭示了一种碱溶性树脂，包括第一单体单元，其中包括至少一个磺酰胺基团和从具有以下结构（I）的单体得到的第二单体单元，其中R1表示包括乙烯基不饱和可聚合基团的结构基团; R2、R3和R4独立地表示氢、可选地取代的烷基、烯基、炔基、烷基芳基、芳基烷基、芳基或杂环芳基基团或形成五至八元环所必需的原子。
• Nickel-Mediated Decarbonylative Cross-Coupling of Phthalimides with in Situ Generated Diorganozinc Reagents
  作者：Sarah E. Havlik、Jessica M. Simmons、Valerie J. Winton、Jeffrey B. Johnson

  DOI：10.1021/jo200347j

  日期：2011.5.6

  The nickel-mediated cross-coupling of phthalimides with diorganozinc reagents proceeds via a decarbonylative process to produce ortho-substituted benzamides in high yields. In addition to tolerating diverse phthalimide functionality, including alkyl, aryl, and heteroatom containing substituents, this methodology proceeds smoothly with diorganozinc reagents prepared from aryl bromides and utilized without purification.
• Asymmetric catalytic reduction of meso-imides
  作者：Jahyo Kang、Jun Won Lee、Joo In Kim、Chongsuh Pyun

  DOI：10.1016/0040-4039(95)00728-u

  日期：1995.6

  A thiazazincolidine complex, 1, was shown to be an excellent catalyst for enantioselective reduction with bis(2,6-dimethylphenoxy)borane (BDMPB) of meso N-phenylimides in high ee to the corresponding hydroxy lactams, which were eventually converted to the corresponding lactones of high optical purity.
• GIESE, BERND;FARSHCHI, HASSAN;HARIMANNS, JORG;METZGER, JURGEN O., ANGEW. CHEM., 103,(1991) N, C. 619-620
  作者：GIESE, BERND、FARSHCHI, HASSAN、HARIMANNS, JORG、METZGER, JURGEN O.

  DOI：——

  日期：——
• US8978554B2
  申请人：——

  公开号：US8978554B2

  公开（公告）日：2015-03-17