2-(benzylthio)pyrazine | 164352-90-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-(benzylthio)pyrazine
• 英文别名: 2-Benzylsulfanyl-pyrazine；2-benzylsulfanylpyrazine
• CAS: 164352-90-3
• 化学式: C₁₁H₁₀N₂S
• 分子量: 202.28
• InChiKey: HGSKLZKJIXMLDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  51.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(benzylthio)pyrazine 在 1,3-二氯-5,5-二甲基海因 、 溶剂黄146 作用下， 以 二氯甲烷 、 水 为溶剂， 生成 吡嗪-2-磺酰氯
  参考文献：
  名称：

  [EN] AMIDE-CONTAINING LONP1 INHIBITOR COMPOUNDS, USES AND METHODS
  [FR] COMPOSÉS INHIBITEURS DE LONP1 CONTENANT DES AMIDES, UTILISATIONS ET PROCÉDÉS

  摘要：

  Disclosed are compounds according to Formula (1) which inhibit LONP1, and pharmaceutical compositions comprising compounds of the disclosure. Compounds and pharmaceutical compositions of the disclosure may be useful for the treatment of diseases and disorders associated with LONP1, including oncologic diseases and disorders, such as cancer, and diseases and disorders related to mitochondrial dysfunction, such as neurodegenerative disorders, metabolic disorders, and diseases associated with the aging process. The disclosure also relates to methods of using such compounds and compositions for the treatment of such diseases and disorders.

  公开号：

  WO2023107481A1
• 作为产物：
  描述：

  2-氯吡嗪 、 苯甲醇 在 Sodium thiosulfate pentahydrate 作用下， 以 neat (no solvent) 为溶剂， 反应 12.0h， 以67%的产率得到2-(benzylthio)pyrazine
  参考文献：
  名称：

  结晶水的促进作用导致由杂芳基氯化物，硫代硫酸钠五水合物和乙醇无催化剂合成杂芳基硫醚

  摘要：

  观察到五水硫代硫酸钠（Na 2 S 2 O 3 ·5H 2 O）中的结晶水可以促进其与杂芳基氯化物和醇类的多组分反应，从而一步一步提供了一种不对称的杂芳基硫醚的简便，绿色且特异的合成方法在无催化剂，无添加剂和无溶剂的条件下形成两个C–S键。机理研究表明，Na 2 S 2 O 3 ·5H 2 O中的结晶水对于生成关键的硫醇中间体和副产物NaHSO 4至关重要，后者可以催化醇被硫醇的脱水取代，从而制得硫醚。

  DOI：

  10.1021/acs.joc.9b01670

文献信息

• Novel Sulfonaminoquinoline Hepcidin Antagonists
  申请人：Buhr Wilm

  公开号：US20120214803A1

  公开（公告）日：2012-08-23

  The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.

  本发明涉及新型肝铁蛋白拮抗剂，包括它们的药物组合物以及将其用作药物治疗铁代谢紊乱，特别是铁缺乏病和贫血等疾病，特别是与慢性炎症性疾病相关的贫血。
• Efficient Generation of C-S Bonds<i>via</i>a By-Product-Promoted Selective Coupling of Alcohols, Organic Halides, and Thiourea
  作者：Xiantao Ma、Lei Yu、Chenliang Su、Yaqi Yang、Huan Li、Qing Xu

  DOI：10.1002/adsc.201700227

  日期：2017.5.17

  alcohols, heteroaryl halides, and thiourea has been developed for direct and selective synthesis of heteroaryl thioethers. This method can be easily scaled up to the gram scale and extended to dialkyl thioethers, heteroaryl selenides, benzothiazoles, and some antimycobacterially‐active thioethers. Mechanistic studies revealed that a by‐product‐promoted in situ C–O activation of alcohols to more reactive

  醇，杂芳基卤化物和硫脲的无金属和无碱三组分偶联已被开发用于直接和选择性地合成杂芳基硫醚。此方法可以轻松扩展至克级，并扩展到二烷基硫醚，杂芳基硒化物，苯并噻唑和一些抗分枝杆菌活性的硫醚。机理研究表明，副产物促进了醇的原位C-O活化，使其反应性更高的烷基卤化物以及硫醇和烷基卤化物中间体的缓慢释放是反应高选择性和成功的关键。
• COMPOSITION FOR EL DEVICE
  申请人：SEMICONDUCTOR ENERGY LABORATORY CO., LTD.

  公开号：US20210395271A1

  公开（公告）日：2021-12-23

  An object is to provide a novel composition for an EL device. Another object of one embodiment of the present invention is to provide a composition for an EL device capable of easily manufacturing an EL device with stable characteristics. Another object of one embodiment of the present invention is to provide a composition for an EL device capable of manufacturing an EL device with stable characteristics at low cost. The present inventors have studied a composition for an EL device in which different substances are mixed in advance and which does not cause change in characteristics of the EL device even when evaporation is repeated with use of the composition. As a result, a composition for an EL device in which a difference in the 5% weight loss temperature under a pressure lower than or equal to 0.1 Pa between contained substances is less than or equal to 50° C. is provided.

  本发明的一个目的是提供一种新颖的EL装置组合物。本发明的一个实施例的另一个目的是提供一种适用于EL装置的组合物，能够轻松制造具有稳定特性的EL装置。本发明的一个实施例的另一个目的是提供一种适用于EL装置的组合物，能够以低成本制造具有稳定特性的EL装置。本发明的发明人研究了一种EL装置组合物，其中不同物质预先混合，并且即使使用该组合物重复蒸发，也不会导致EL装置特性的变化。因此，提供了一种适用于EL装置的组合物，其中在压力小于或等于0.1 Pa的条件下，所含物质的5％失重温度之间的差异小于或等于50℃。
• Sulfonaminoquinoline hepcidin antagonists
  申请人：Vifor (International) AG

  公开号：US09102688B2

  公开（公告）日：2015-08-11

  The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.

  本发明涉及新型的赫普西丁拮抗剂，包括它们的药物组合物和将其作为药物用于治疗铁代谢紊乱的用途，特别是铁缺乏症和贫血，特别是与慢性炎症性疾病相关的贫血。
• Prevention of bone resorption
  申请人：ELI LILLY AND COMPANY

  公开号：EP0587378A1

  公开（公告）日：1994-03-16

  The administration of a xanthine oxidase inhibitor is effective for the treatment or prevention of the excessive resorption of bone in conditions such as osteoporosis and the like.

  服用黄嘌呤氧化酶抑制剂可有效治疗或预防骨质疏松症等情况下的骨过度吸收。