dilauroyl-amine | 112605-93-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: dilauroyl-amine
• 英文别名: N-Dodecanoyldodecanamide
• CAS: 112605-93-3
• 化学式: C₂₄H₄₇NO₂
• 分子量: 381.643
• InChiKey: GPFGAVGMIKVVMZ-UHFFFAOYSA-N

物化性质

• 沸点：
  496.4±14.0 °C(Predicted)
• 密度：
  0.892±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  27
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  月桂酰氯 、 月桂酰胺 生成 dilauroyl-amine
  参考文献：
  名称：

  Preparation of the higher monoacylamides from monoamides and acid halides

  摘要：

  公开号：

  US02672470A1

文献信息

• [EN] NOVEL LIPIDS AND LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS<br/>[FR] NOUVEAUX LIPIDES ET FORMULATIONS NANOPARTICULAIRES LIPIDIQUES POUR L'ADMINISTRATION D'ACIDES NUCLÉIQUES
  申请人：ACUITAS THERAPEUTICS INC

  公开号：WO2015199952A1

  公开（公告）日：2015-12-30

  Compounds are provided having the following structure: (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, a, b, c, d and e are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

  提供具有以下结构的化合物：(I)或其药用盐、互变异构体或立体异构体，其中R1a、R1b、R2a、R2b、R3a、R3b、R4a、R4b、R5、R6、R7、R8、R9、L1、L2、a、b、c、d和e的定义如本文所述。还提供了将这些化合物用作脂质纳米粒子制剂的组分、包含这些化合物的组合物以及其使用和制备方法。
• Method of Administration of Dopamine Receptor Agonists
  申请人：Fernandes B. Prabhavathi

  公开号：US20070254906A1

  公开（公告）日：2007-11-01

  Methods for treating a patient having pulmonary edema are described. The methods include administering to the lung endobronchial space of the airways of the patient an effective amount of a dopamine D 1 receptor agonist. Dopamine D 1 receptor agonists, including hexahydrobenzophenanthridine, hexahydrothienophenanthridine, phenyltetrahydrobenzazepine, chromenoisoquinoline, naphthoisoquinoline dopamine receptor agonists, and their pharmaceutically acceptable salts, formulated as aerosols and dry powders are also described.

  本文描述了治疗肺水肿患者的方法。该方法包括向患者的呼吸道肺内支气管空间内注射有效量的多巴胺D1受体激动剂。本文还介绍了多巴胺D1受体激动剂，包括六氢苯并苯并芳烃、六氢噻吩并芳烃、苯基四氢苯并氮杂环、香豆素异喹啉、萘异喹啉多巴胺受体激动剂及其药学上可接受的盐，制成气溶胶和干粉。
• NOVEL LIPIDS AND LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS
  申请人：Acuitas Therapeutics Inc.

  公开号：US20150376115A1

  公开（公告）日：2015-12-31

  Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R 1a , R 1b , R 2a , R 2b , R 3a , R 3b , R 4a , R 4b , R 5 , R 6 , R 7 , R 8 , R 9 , L 1 , L 2 , a, b, c, d and e are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

  提供具有以下结构的化合物：其中R1a，R1b，R2a，R2b，R3a，R3b，R4a，R4b，R5，R6，R7，R8，R9，L1，L2，a，b，c，d和e的药物可接受的盐，互变异构体或立体异构体，如此处所定义。还提供将该化合物用作脂质纳米粒子配方的组分，用于传递治疗剂的组成物以及其使用和制备方法。
• Thermochromic microencapsulated pigments
  申请人：THE PILOT INK CO., LTD.

  公开号：EP1084860A2

  公开（公告）日：2001-03-21

  Disclosed is a thermochromic microencapsulated pigment which comprises as four essential components (a) an electron-donating chromatic organic compound, (b) an electron-accepting compound, (c) a reaction medium determining the temperatures at which the color reactions of component (a) with component (b) take place, and (d) a color change temperature regulator, the color change temperature regulator (d) comprising one or more compounds selected from the group consisting of esters, alcohols, ketones, acid amides, hydrocarbons, and fatty acids and having a melting point Y (°C) satisfying the relationship (X+30)°C≤Y≤200°C, wherein X (°C) is the melting point of component (c), and the four essential components being microencapsulated.

  本发明公开了一种热致变色微胶囊颜料，它由四种基本成分组成：(a) 一种电子供色有机化合物；(b) 一种电子受色化合物；(c) 一种决定成分(a)与成分(b)发生颜色反应的温度的反应介质；(d) 一种变色温度调节剂、变色温度调节剂(d)包括一种或多种从酯、醇、酮、酸酰胺、烃和脂肪酸组成的组中选出的化合物，其熔点 Y(℃)满足(X+30)℃≤Y≤200℃的关系，其中 X(℃)是组分(c)的熔点，四种基本组分被微胶囊化。
• Pressure sensitive coating for image forming
  申请人：Chromatic Technologies, Inc.

  公开号：US10005304B2

  公开（公告）日：2018-06-26

  A microencapsulated pigment including a leuco dye system is incorporated as one or more layers in a roll of adhesive tape. The tape is applied and may be rubbed by hand or another object to induce a color change. The change may serve as an indicator that the tape is well adhered for masking purposes in a painting operation, or to present a design where only selected portions of the tape are rubbed to induce the color change. The microencapsulated pigment may be constructed so that the color change is irreversible or reversible.

  在一卷胶带中加入一层或多层微胶囊颜料，其中包括一种leuco 染料系统。贴上胶带后，用手或其他物体摩擦胶带，胶带就会发生颜色变化。这种变化可作为胶带粘合良好的指示剂，用于涂漆作业中的遮蔽目的，或用于展示一种设计，即只摩擦胶带的选定部分以引起颜色变化。微胶囊颜料的结构可以使颜色变化不可逆或可逆。