4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-7,8-dihydroxy-2H-chromen-2-one | 877800-14-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-7,8-dihydroxy-2H-chromen-2-one
• 英文别名: 4-((4-(2-Fluorophenyl)piperazin-1-yl)methyl)-6,7-dihydroxy-2H-chromen-2-one (6)；4-[[4-(2-fluorophenyl)piperazin-1-yl]methyl]-7,8-dihydroxychromen-2-one
• CAS: 877800-14-1
• 化学式: C₂₀H₁₉FN₂O₄
• 分子量: 370.38
• InChiKey: JTHOJFWBSWDWDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  73.2
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  邻苯三酚 在 高氯酸 作用下， 以 丙酮 为溶剂， 反应 32.0h， 生成 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-7,8-dihydroxy-2H-chromen-2-one
  参考文献：
  名称：

  Synthesis, antielastase, antioxidant and radical scavenging activities of 4-(aza substituted) methylene substituted dihydroxy coumarines

  摘要：

  A series of some 4-(aza substituted) methylene substituted dihydroxy coumarines were evaluated for their antioxidant and antielastase activities. Different in vitro methodologies such as total reducing power, 1,1-diphenyl-2-picrylhydrazil (DPPH.) free radical scavenging, ABTS radical scavenging activity were used as antioxidant activity. All the tested compounds exhibited potent free radical scavenging ability and antielastase activites.

  DOI：

  10.3109/14756366.2012.692086

文献信息

• Synthesis, antielastase, antioxidant and radical scavenging activities of 4-(aza substituted) methylene substituted dihydroxy coumarines
  作者：Bahar Bilgin Sokmen、Gulsah Aydin、Arzu Gumus、Seref Karadeniz、Halil Ibrahim Ugras、Refiye Yanardag、Umit Cakır

  DOI：10.3109/14756366.2012.692086

  日期：2013.8.1

  A series of some 4-(aza substituted) methylene substituted dihydroxy coumarines were evaluated for their antioxidant and antielastase activities. Different in vitro methodologies such as total reducing power, 1,1-diphenyl-2-picrylhydrazil (DPPH.) free radical scavenging, ABTS radical scavenging activity were used as antioxidant activity. All the tested compounds exhibited potent free radical scavenging ability and antielastase activites.