2-methoxy-1-eicosanol | 104532-21-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-methoxy-1-eicosanol
• 英文别名: (d,l)-1-hydroxy-2-methoxyeicosane；2-Methoxyicosan-1-ol
• CAS: 104532-21-0
• 化学式: C₂₁H₄₄O₂
• 分子量: 328.579
• InChiKey: CPDIFCDAAKZGIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  23
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methoxy-1-eicosanol 在 吡啶 、 水 、 三乙胺 、 三氯氧磷 作用下， 以 四氢呋喃 为溶剂， 反应 5.58h， 生成 rac-(2-methoxyeicos-1-yl)phosphocholine
  参考文献：
  名称：

  Antitumor activity of (2-alkoxyalkyl)- and (2-alkoxyalkenyl)phosphocolines

  摘要：

  Analogues of the synthetic antitumor phospholipid ALP (1-octadecyl-2-methyl-sn-glycero-3-phosphocholine; alkyl lysophospholipid) in which the 1-ether oxygen atom has been removed have been prepared and evaluated for in vitro and in vivo anticancer activity. Compounds are presented in which the saturated long chain varies in length from 8 to 25 carbon atoms. Sites of unsaturation are also incorporated into the framework in some examples. In particular, rac-(2-ethoxyeicosyl)phosphocholine (10) displays the best in vivo activity of the chemical series against a variety of transplanted tumors and activates murine peritoneal macrophages to express tumor cytotoxicity in vitro. However, 10 does not offer the wide spectrum of antitumor activity we feel necessary to warrant further study.

  DOI：

  10.1021/jm00162a009
• 作为产物：
  描述：

  Methyl 2-methoxyeicosanoate 生成 2-methoxy-1-eicosanol
  参考文献：
  名称：

  BOSIES, E.;GALL, R.;WEIMANN, G.;BICKER, U.;PAHIKE, W.

  摘要：

  DOI：

文献信息

• 2-alkoxy-1-alkoxy phosphoryl dichlorides
  申请人：Eli Lilly and Company

  公开号：US04659859A1

  公开（公告）日：1987-04-21

  2-Alkoxy C.sub.12-26 straight-chain alkyl hydroxyphosphoryl cholines, useful as hypotensive agents, anti-cancer agents and as anti-inflammatory agents.

  2-烷氧基C.sub.12-26直链烷基羟基磷酰胆碱，可用作降压剂、抗癌剂和抗炎剂。
• Hair growers
  申请人：——

  公开号：US20030198614A1

  公开（公告）日：2003-10-23

  The present invention provides a hair growth promoting composition having an excellent hair growth promoting effect. The hair promoting composition comprises, as an effective ingredient, a composition expressed by following Formula (I): 1 wherein one of R 1 to R 4 is selected from a group of C 14-22 alkyl, C 14-22 alkoxy and C 14-22 acyloxy groups, and the others are selected from a group of H, OH, C 1-3 alkyl and C 1-3 alkoxy groups; and when R 1 is C 14-22 alkoxy group and one of R 2 and R 4 is C 1-3 alkoxy group, R 3 is H, C 1-3 alkyl or C 1-3 alkoxy group; and when R 1 is C 14-22 acyloxy group, at least one of R 2 to R 4 is C 1-3 alkoxy group.

  本发明提供了一种具有优异的促进头发生长效果的促进头发生长的组合物。该促进头发生长的组合物包括以下式（I）所表示的组合物作为有效成分：其中R1至R4中的一个选择自C14-22烷基，C14-22烷氧基和C14-22酰氧基的一组，而其他的选择自H，OH，C1-3烷基和C1-3烷氧基的一组；当R1为C14-22烷氧基且R2和R4中的一个为C1-3烷氧基时，R3为H，C1-3烷基或C1-3烷氧基；当R1为C14-22酰氧基时，R2至R4中至少有一个为C1-3烷氧基。
• HAIR GROWERS
  申请人：Shiseido Co., Ltd.

  公开号：EP1314417A1

  公开（公告）日：2003-05-28

  The present invention provides a hair growth promoting composition having an excellent hair growth promoting effect. The hair promoting composition comprises, as an effective ingredient, a composition expressed by following Formula (I): wherein one of R1 to R4 is selected from a group of C14-22 alkyl, C14-22 alkoxy and C14-22 acyloxy groups, and the others are selected from a group of H, OH, C1-3 alkyl and C1-3 alkoxy groups; and when R1 is C14-22 alkoxy group and one of R2 and R4 is C1-3 alkoxy group, R3 is H, C1-3 alkyl or C1-3 alkoxy group; and when R1 is C14-22 acyloxy group, at least one of R2 to R4 is C1-3 alkoxy group.

  本发明提供了一种具有极佳生发效果的生发组合物。该生发组合物包括作为有效成分的由下式（I）表示的组合物： 其中 R1 至 R4 中的一个选自 C14-22 烷基、C14-22 烷氧基和 C14-22 乙酰氧基，其它选自 H、OH、C1-3 烷基和 C1-3 烷氧基；当 R1 为 C14-22 烷氧基且 R2 和 R4 中的一个为 C1-3 烷氧基时，R3 为 H、C1-3 烷基或 C1-3 烷氧基；当 R1 为 C14-22 乙酰氧基时，R2 至 R4 中至少有一个为 C1-3 烷氧基。
• BOSIES, E.;GALL, R.;WEIMANN, G.;BICKER, U.;PAHIKE, W.
  作者：BOSIES, E.、GALL, R.、WEIMANN, G.、BICKER, U.、PAHIKE, W.

  DOI：——

  日期：——
• US4659859A
  申请人：——

  公开号：US4659859A

  公开（公告）日：1987-04-21