tryptophyl bromide | 55982-76-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tryptophyl bromide
• 英文别名: trytophyl bromide；2-amino-3-indol-3-yl-propionyl bromide；Tryptophylbromid；2-amino-3-(1H-indol-3-yl)propanoyl bromide
• CAS: 55982-76-8
• 化学式: C₁₁H₁₁BrN₂O
• 分子量: 267.125
• InChiKey: KUJVITUFPXHPGK-UHFFFAOYSA-N

物化性质

• 熔点：
  90-95 °C
• 沸点：
  414.3±40.0 °C(Predicted)
• 密度：
  1.613±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  tryptophyl bromide 在 盐酸 、 potassium carbonate 作用下， 以 甲醇 、 水 、 丙酮 为溶剂， 反应 37.0h， 生成 3-(2-(1H-indol-3-yl)ethyl)quinazoline-2,4(1H,3H)-dione
  参考文献：
  名称：

  Kaneko, Chikara; Chiba, Takuo; Kasai, Kouichi, Heterocycles, 1985, vol. 23, # 6, p. 1385 - 1390

  摘要：

  DOI：

文献信息

• [EN] POLYCYCLIC COMPOUNDS AS POTENT ALPHA2-ADRENOCEPTOR ANTAGONISTS<br/>[FR] COMPOSES POLYCYCLIQUES COMME ANTAGONISTES PUISSANTS DES RECEPTEURS DOLLAR G(A)2-ADRENERGIQUES
  申请人：ORION CORP

  公开号：WO2003082866A1

  公开（公告）日：2003-10-09

  The invention provides a compound of formula I, wherein X, Z, R1 to R10, R15, R16, m, n, r and t are as defined in claim 1, or a pharmaceutically acceptable salt or ester thereof, useful as an alpha-2 antagonist. The compounds of formula I can be used for the treatment of diseases or conditions where antagonists of alpha-2 adrenoceptors are indicated to be effective.

  本发明提供了一种式I的化合物，其中X、Z、R1至R10、R15、R16、m、n、r和t如权利要求1所定义，或其药学上可接受的盐或酯，用作α-2拮抗剂。式I的化合物可用于治疗需要α-2肾上腺素受体拮抗剂有效的疾病或情况。
• 2-Azabicyclo(2.2.2)octane derivatives and their use as immunosuppressive
  申请人：Richter Gedeon Vegyeszeti Gyar Rt.

  公开号：US04563464A1

  公开（公告）日：1986-01-07

  The invention relates to new 2-azabicyclo[2.2.2]octane derivatives of the formula (I), ##STR1## wherein A is hydrogen, alkoxycarbonyl having from one to 4 carbon atoms in the alkoxy group, phenylalkoxycarbonyl having from one to 4 carbon atoms in the alkoxy moiety, alkyl having from one to 6 carbon atoms, aralkyl containing from one to 4 carbon atoms in the alkyl moiety or substituted acyl, R.sub.1 is hydrogen or alkyl having from one to 4 carbon atoms, Z is hydrogen or halogen, X is hydrogen or halogen, Y is hydrogen, or X and Y together represent a C--C bond, W is alkoxycarbonyl having from one to 4 carbon atoms in the alkoxy moiety, cyano, carboxamido or haloformyl, or if X stands for halogen, X and Y together represent a ##STR2## group. According to another aspect of the invention there is provided a process for the preparation of the above compounds, which are pharmaceutically active, in particular, possess valuable anticonvulsive, vasodilating or gastric acid secretion inhibiting properties. Pharmaceutical compositions containing compounds of the formula (I) are also within the scope of the invention.

  该发明涉及公式（I）的新2-azabicyclo[2.2.2]辛烷衍生物，其中A是氢，烷氧羰基在烷氧基中含有1至4个碳原子，苯基烷氧羰基在烷氧基中含有1至4个碳原子，烷基含有1至6个碳原子，芳基烷基在烷基中含有1至4个碳原子或取代酰基，R.sub.1是氢或含有1至4个碳原子的烷基，Z是氢或卤素，X是氢或卤素，Y是氢，或X和Y一起代表一个C-C键，W是烷氧羰基在烷氧基中含有1至4个碳原子，氰基，羧酰胺基或卤代甲酰基，或者如果X代表卤素，则X和Y一起代表一个##STR2##基团。根据该发明的另一个方面提供了制备上述化合物的方法，这些化合物在药理学上具有活性，特别是具有有价值的抗惗性、扩血管或抑制胃酸分泌的性质。包含公式（I）化合物的药物组合物也在该发明的范围内。
• Indolo[2,3-a]quinolizine and indolo[2,3-g]cyclopent[a]indolizine
  申请人：Richter Gedeon Vegyeszeti Gyar R.T.

  公开号：US04587251A1

  公开（公告）日：1986-05-06

  The invention relates to new indolo[2,3-g]cyclopent[a]indolizine derivatives of the formulae (II) ##STR1## and/or (III) ##STR2## wherein W is alkoxycarbonyl having from one to four carbon atoms in the alkoxy moiety or cyano, R.sub.1 is hydrogen or alkyl having from one to four carbon atoms, G is a >CH.sub.2 or >C.dbd.O group, and X and Y each stands for hydrogen or together represent a C--C bond. According to another aspect of the invention there is provided a process for the preparation of the above compounds, which are pharmaceutically active, in particular, possess valuable gastric acid secretion inhibiting activity. Pharmaceutical compositions containing compounds of the formulae (II) and/or (III) are also within the scope of the invention.

  该发明涉及新的indolo[2,3-g]cyclopent[a]indolizine衍生物，其化学式为(II)和/或(III)，其中W为在烷氧基团中具有一到四个碳原子的烷氧羰基或氰基，R.sub.1为氢或具有一到四个碳原子的烷基，G为>CH.sub.2或>C.dbd.O基团，X和Y分别代表氢原子或一起表示一个碳-碳键。根据该发明的另一个方面，提供了制备上述化合物的过程，这些化合物在药理上具有活性，特别是具有有价值的胃酸分泌抑制活性。含有化学式(II)和/或(III)化合物的药物组合物也在该发明的范围内。
• 1,6-Dihydro-3(2H)-pyridinones. VIII. Total synthesis of (.+-.)-corynantheidol and formal synthesis of (.+-.)-quinine.
  作者：TAKESHI IMANISHI、MAKOTO INOUE、YASUAKI WADA、MIYOJI HANAOKA

  DOI：10.1248/cpb.31.1551

  日期：——

  cis-3, 4-Disubstituted piperidine compounds (2 and 3) were stereoselectively prepared from benzyl 3-(1, 3-dioxolan-2-ylmethyl)-1, 2, 3, 6-tetrahydropyridine-1-carboxylate (13) via the ketone (17). A total synthesis of (±)-corynantheidol (4) and a formal synthesis of (±)-quinine (5) have also been achieved from the piperidines 2 and 3, respectively.

  顺式-3, 4-二取代哌啶化合物（2 和 3）是由 3-(1,3-二氧戊环-2-基甲基)-1, 2, 3, 6-四氢吡啶-1-甲酸苄酯 (13) 通过酮 (17) 立体选择性地制备的。此外，还分别从哌啶 2 和哌啶 3 中完全合成了 (±)-corynantheidol (4)，并正式合成了 (±)-quinine (5)。
• Polycyclic compounds as potent alpha2-adrenoceptor antagonists
  申请人：Din Belle David

  公开号：US20060094740A1

  公开（公告）日：2006-05-04

  A compound of formula 1, wherein X, Z, R 1 to R 10 , R 15 , R 16 , m, n, r and t are as defined in claim 1, or a pharmaceutically acceptable salt or ester thereof, useful as an alpha-2 antagonist. The compounds of formula I can be used for the treatment of diseases or conditions where antagonists of alpha-2 adrenoceptors are indicated to be effective.

  一种公式1的化合物，其中X，Z，R1至R10，R15，R16，m，n，r和t如权利要求1中所定义，或其药学上可接受的盐或酯，可用作α-2拮抗剂。公式I的化合物可用于治疗需要α-2肾上腺素能受体拮抗剂有效的疾病或情况。