申请人:MERCK PATENT GmbH
公开号:EP0895987A1
公开(公告)日:1999-02-10
A process for the preparation of a highly pure alkyl 2-cyanoacrylate,
wherein alkyl has 1-10 C atoms,
characterized in that
a) formaldehyde is reacted with an alkyl cyanoacetate ester by means of a catalyst in a solvent mixture selected from the group comprising ethylacetate, diglyme, dichloroethane and benzene,
yielding an oligo-(alkyl 2-cyanoacrylate);
b) the product of (a) is separated in the form of a solid;
c) the product of (b) is depolymerized under sulfur dioxide atmosphere free from other polymerization inhibitors
to yield an alkyl 2-cyanoacrylate with a purity of 98 - 100 %.
一种制备高纯度 2-氰基丙烯酸烷基酯的工艺、
其中烷基有 1-10 个 C 原子、
其特征在于
a) 在选自乙酸乙酯、二甘醇、二氯乙烷和苯的混合溶剂中,通过催化剂使甲醛与氰乙酸烷基酯反应、
生成低聚 2-氰基丙烯酸烷基酯;
b) (a) 项的产物以固体形式分离;
c) 在不含其他聚合抑制剂的二氧化硫气氛下对(b)的产物进行解聚
得到纯度为 98-100 % 的 2-氰基丙烯酸烷基酯。