N-[(2S)-1-hexadecoxy-3-hydroxypropan-2-yl]hexadecanamide | 136770-77-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-[(2S)-1-hexadecoxy-3-hydroxypropan-2-yl]hexadecanamide
• CAS: 136770-77-9
• 化学式: C₃₅H₇₁NO₃
• 分子量: 553.954
• InChiKey: DOSWXUKIEDOBNA-UMSFTDKQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.9
• 重原子数：
  39
• 可旋转键数：
  33
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  三乙胺 、 N-[(2S)-1-hexadecoxy-3-hydroxypropan-2-yl]hexadecanamide 在 咪唑 、 三氯化磷 作用下， 生成
  参考文献：
  名称：

  A Convenient Synthesis of 1-Ether-2-acylamido-2-deoxy-sn-glycerophospholipids

  摘要：

  A series of 1-ether-sn-2-acylamidoglycerophospholipids, bearing different polar heads in sn-3-position such as phosphoglycol, -serine, -ethanolamine or -choline, have been prepared. Except for the choline derivative which was synthesized from a beta-carbamate alcohol derivative, the remaining compounds were obtained from beta-amidoalcohols.

  DOI：

  10.1080/00397919308011175
• 作为产物：
  描述：

  十六烷基甲烷磺酸酯 在 盐酸 、 4-二甲氨基吡啶 、 potassium hydride 作用下， 以 乙醇 、 氯仿 为溶剂， 反应 44.0h， 生成 N-[(2S)-1-hexadecoxy-3-hydroxypropan-2-yl]hexadecanamide
  参考文献：
  名称：

  A Convenient Synthesis of 1-Ether-2-acylamido-2-deoxy-sn-glycerophospholipids

  摘要：

  A series of 1-ether-sn-2-acylamidoglycerophospholipids, bearing different polar heads in sn-3-position such as phosphoglycol, -serine, -ethanolamine or -choline, have been prepared. Except for the choline derivative which was synthesized from a beta-carbamate alcohol derivative, the remaining compounds were obtained from beta-amidoalcohols.

  DOI：

  10.1080/00397919308011175

文献信息

• A Convenient Synthesis of 1-Ether-2-acylamido-2-deoxy-<i>sn</i>-glycerophospholipids
  作者：M. L. García、J. Pascual、G. González、A. Palomer、M. Cabré、J. A. Andreu、D. Mauleón、G. Carganico

  DOI：10.1080/00397919308011175

  日期：1993.12

  A series of 1-ether-sn-2-acylamidoglycerophospholipids, bearing different polar heads in sn-3-position such as phosphoglycol, -serine, -ethanolamine or -choline, have been prepared. Except for the choline derivative which was synthesized from a beta-carbamate alcohol derivative, the remaining compounds were obtained from beta-amidoalcohols.