9-(4-Bromophenyl)-1-nonene | 254892-86-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 9-(4-Bromophenyl)-1-nonene
• 英文别名: 1-Bromo-4-non-8-enylbenzene
• CAS: 254892-86-9
• 化学式: C₁₅H₂₁Br
• 分子量: 281.236
• InChiKey: RRRHSJGIVQFILA-UHFFFAOYSA-N

物化性质

• 沸点：
  346.0±21.0 °C(Predicted)
• 密度：
  1.129±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  9-(4-Bromophenyl)-1-nonene 在 盐酸 、 正丁基锂 、 铜 、 对甲苯磺酸 、 溶剂黄146 、 锌 、 三氯氧磷 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 、 正己烷 、 苯 为溶剂， 反应 27.5h， 生成 3-[7-(4-boronophenyl)heptyl]cyclobutanone
  参考文献：
  名称：

  4-Dihydroxyborylphenyl Analogues of 1-Aminocyclobutanecarboxylic Acids:  Potential Boron Neutron Capture Therapy Agents

  摘要：

  A series of 4-dihydroxyborylphenyl analogues of an unnatural alpha-amino acid, 1-aminocyclobutanecarboxylic acid (ACBC), was synthesized. Varying numbers of methylene units were introduced between the 4-boronophenyl and ACBC moieties in order to introduce different degrees of lipophilicity into the molecules. The key step in the syntheses was the preparation of the precursor p-boronophenyl-substituted cyclobutanones which were subsequently converted to the desired amino acids via the Bucherer-Strecker reaction.

  DOI：

  10.1021/jo990878c
• 作为产物：
  描述：

  magnesium,oct-1-ene,bromide 、 对溴溴苄 在 dilithium tetrachlorocuprate 作用下， 以 四氢呋喃 为溶剂， 以42%的产率得到9-(4-Bromophenyl)-1-nonene
  参考文献：
  名称：

  4-Dihydroxyborylphenyl Analogues of 1-Aminocyclobutanecarboxylic Acids:  Potential Boron Neutron Capture Therapy Agents

  摘要：

  A series of 4-dihydroxyborylphenyl analogues of an unnatural alpha-amino acid, 1-aminocyclobutanecarboxylic acid (ACBC), was synthesized. Varying numbers of methylene units were introduced between the 4-boronophenyl and ACBC moieties in order to introduce different degrees of lipophilicity into the molecules. The key step in the syntheses was the preparation of the precursor p-boronophenyl-substituted cyclobutanones which were subsequently converted to the desired amino acids via the Bucherer-Strecker reaction.

  DOI：

  10.1021/jo990878c

文献信息

• Process for preparing 1-bromoalkylbenzene derivatives and intermediates thereof
  申请人：SUMITOMO CHEMICAL COMPANY LIMITED

  公开号：EP0637580A1

  公开（公告）日：1995-02-08

  A 1-bromoalkylbenzene derivative is prepared by reacting a phenylalkene derivative with hydrogen bromide in the presence of a non-polar solvent. The phenylalkene derivative is prepared by reacting an alkenyl halide with metal magnesium to form a Grignard reagent, and then reacting the Grignard reagent with a benzyl halide derivative. An allyl Grignard reagent is prepared by reacting continuously an allyl halide derivative with metal magnesium in an organic solvent, in which the allyl halide derivative and metal magnesium are continuously added to the reaction system and the allyl Grignard reagent formed is continuously removed from the reaction system. The processes provide the intended compounds in high yields, high selectivities and high purities.

  1-bromoalkylbenzene derivative is prepared by reacting a phenylalkene derivative with hydrogen bromide in the presence of a non-polar solvent.苯基烷烃衍生物的制备方法是先使烯基卤化物与金属镁反应生成格氏试剂，然后使格氏试剂与苄基卤化物衍生物反应。烯丙基格氏试剂是通过烯丙基卤化物衍生物与金属镁在有机溶剂中连续反应制备的，其中烯丙基卤化物衍生物和金属镁被连续加入反应体系，形成的烯丙基格氏试剂被连续从反应体系中移除。这些工艺可提供高产率、高选择性和高纯度的预期化合物。
• ORGANIC ELECTRONIC MATERIAL AND ORGANIC ELECTRONIC ELEMENT
  申请人：Showa Denko Materials Co., Ltd.

  公开号：EP3859806A1

  公开（公告）日：2021-08-04

  An embodiment of the present invention relates to an organic electronic material that comprises a charge transporting polymer which has a branched structure and has a constituent unit having a structure represented by formula (1).

  本发明的一个实施方案涉及一种有机电子材料，它包括一种电荷传输聚合物，该聚合物具有支链结构，其组成单元具有式（1）表示的结构。
• US5637736A
  申请人：——

  公开号：US5637736A

  公开（公告）日：1997-06-10
• US6063940A
  申请人：——

  公开号：US6063940A

  公开（公告）日：2000-05-16
• 4-Dihydroxyborylphenyl Analogues of 1-Aminocyclobutanecarboxylic Acids:  Potential Boron Neutron Capture Therapy Agents
  作者：Rajiv R. Srivastava、Robert R. Singhaus、George W. Kabalka

  DOI：10.1021/jo990878c

  日期：1999.11.1

  A series of 4-dihydroxyborylphenyl analogues of an unnatural alpha-amino acid, 1-aminocyclobutanecarboxylic acid (ACBC), was synthesized. Varying numbers of methylene units were introduced between the 4-boronophenyl and ACBC moieties in order to introduce different degrees of lipophilicity into the molecules. The key step in the syntheses was the preparation of the precursor p-boronophenyl-substituted cyclobutanones which were subsequently converted to the desired amino acids via the Bucherer-Strecker reaction.