6-propargylamido-1-hexanol | 943858-72-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-propargylamido-1-hexanol
• 英文别名: 6-Hydroxy-N-2-propyn-1-ylhexanamide；6-hydroxy-N-prop-2-ynylhexanamide
• CAS: 943858-72-8
• 化学式: C₉H₁₅NO₂
• 分子量: 169.224
• InChiKey: MUALFEIYNKHACZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-propargylamido-1-hexanol 、 2-氰乙基N,N-二异丙基氯亚磷酰胺 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以55%的产率得到6-propargylamidohexan-1-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  参考文献：
  名称：

  Template-Directed Oligonucleotide Strand Ligation, Covalent Intramolecular DNA Circularization and Catenation Using Click Chemistry

  摘要：

  The copper-catalyzed azide-alkyne cycloaddition reaction has been used for the template-mediated chemical ligation of two oligonucleotide strands, one with a 5'-alkyne and the other with a 3'-azide, to produce a DNA strand with an unnatural backbone at the ligation point. A template-free click-ligation reaction has been used for the intramolecular circularization of a single stranded oligonucleotide which was used as a template for the synthesis of a covalently closed DNA catenane.

  DOI：

  10.1021/ja070273v
• 作为产物：
  描述：

  6-(叔丁基二甲基硅氧基)己酸 在 四丁基氟化铵 、 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 5.0h， 生成 6-propargylamido-1-hexanol
  参考文献：
  名称：

  Template-Directed Oligonucleotide Strand Ligation, Covalent Intramolecular DNA Circularization and Catenation Using Click Chemistry

  摘要：

  The copper-catalyzed azide-alkyne cycloaddition reaction has been used for the template-mediated chemical ligation of two oligonucleotide strands, one with a 5'-alkyne and the other with a 3'-azide, to produce a DNA strand with an unnatural backbone at the ligation point. A template-free click-ligation reaction has been used for the intramolecular circularization of a single stranded oligonucleotide which was used as a template for the synthesis of a covalently closed DNA catenane.

  DOI：

  10.1021/ja070273v

文献信息

• Incorporation of Primary Amines into a Polyester Chain by a Combination of Chemical and Lipase-Catalyzed ɛ-Caprolactone Ring-Opening Processes
  作者：Mattia Marzorati、Karl Hult、Sergio Riva、Bruno Danieli

  DOI：10.1002/adsc.200600642

  日期：2007.8.6

  A simple chemoenzymatic strategy for the incorporation of bioactive and suitably functionalized molecules into a polyester chain has been developed. The protocol involves first the reaction of a primary amine with ε-caprolactone to give an amide carrying a terminal primary hydroxy group, followed by the enzymatic growth of the polymeric chain triggered by Novozym 435. This method is versatile and easy

  已经开发出一种用于将生物活性和适当官能化的分子掺入聚酯链的简单化学酶策略。该方案首先涉及伯胺与ε-己内酯的反应，以生成带有末端伯羟基的酰胺，然后由Novozym 435引发聚合物链的酶促生长。该方法用途广泛，易于操作，适用于如模型化合物苄胺和色胺，生物活性化合物N-去乙酰基硫代秋水仙碱以及官能化的炔丙基胺和酪胺所示，用于将不同的胺掺入聚酯中。
• Template-Directed Oligonucleotide Strand Ligation, Covalent Intramolecular DNA Circularization and Catenation Using Click Chemistry
  作者：Ravindra Kumar、Afaf El-Sagheer、John Tumpane、Per Lincoln、L. Marcus Wilhelmsson、Tom Brown

  DOI：10.1021/ja070273v

  日期：2007.5.1

  The copper-catalyzed azide-alkyne cycloaddition reaction has been used for the template-mediated chemical ligation of two oligonucleotide strands, one with a 5'-alkyne and the other with a 3'-azide, to produce a DNA strand with an unnatural backbone at the ligation point. A template-free click-ligation reaction has been used for the intramolecular circularization of a single stranded oligonucleotide which was used as a template for the synthesis of a covalently closed DNA catenane.