γ-Acetylpropionsaeurebutylamid | 73964-78-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: γ-Acetylpropionsaeurebutylamid
• 英文别名: N-butyl-4-oxopentanamide
• CAS: 73964-78-0
• 化学式: C₉H₁₇NO₂
• 分子量: 171.239
• InChiKey: KYYKFFSWYAVLOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-acetyl-(3H,5H)-tetrahydrothiophene-2,4-dione 、 正丁胺 生成 γ-Acetylpropionsaeurebutylamid
  参考文献：
  名称：

  Thiolane-2,4-dione 和衍生物的碱诱导光反应的多样性。碳骨架的还原环解理和新的重排

  摘要：

  在碱存在的情况下，在甲醇中对硫戊环-2,4-二酮（硫代特酮酸）及其衍生物 1a-1d 进行辐照诱导还原性环裂解，生成 β,β'-二酮酯。在非质子溶剂（如乙腈或丙酮）中也观察到碱诱导的还原环裂解，尽管在这些情况下获得的产物是 β,β'-二酮酰胺。另一方面，在碱存在的情况下，在水中照射 1a-1d 会引起碳骨架的重排，生成琥珀酸硫酐、γ-酮酰胺或琥珀酰胺以及还原产物。当吡啶用作水中光解的碱时，两种 3-乙酰基衍生物 1a 和 1b 产生 γ-酮硫醇和相应的二硫化物，这是由另一种类型的碳骨架重排产生的。

  DOI：

  10.1246/bcsj.52.3601

文献信息

• METHOD FOR PREPARING RIBONUCLEOSIDE PHOSPHOROTHIOATE
  申请人：Wada Takeshi

  公开号：US20130184450A1

  公开（公告）日：2013-07-18

  A method for preparing a phosphorothioate RNA based on the oxazaphospholidine method, wherein cyanoethoxymethyl group is used instead of tert-butyldimethylsilyl group as a protective group of 2′-hydroxyl group of RNA.

  一种基于氧磷硫酸酯RNA的制备方法，其中使用氰乙氧甲基基团代替叔丁基二甲基硅基团作为RNA的2'-羟基的保护基。
• Solubilization and Targeted Delivery of Drugs With Self-Assembling Amphiphilic Polymers
  申请人：Diwan Anil

  公开号：US20100260743A1

  公开（公告）日：2010-10-14

  There are provided amphiphilic biodegradable copolymers comprising a hydrophilic backbone with pendant aliphatic groups as the hydrophobic component. The polymers form nanoscale molecular aggregates in aqueous environments, which have hydrophobic interiors that are capable of solubilizing insoluble organic compounds such as drugs, vitamins, dyes, and imaging agents. The polymers optionally feature reactive functional groups that provide attachment points for antibodies, ligands, and other targeting moieties useful for the targeted delivery of drugs and imaging agents.

  提供的两性可降解共聚物包括具有羟基亲水骨架和作为疏水组分的脂肪族侧链的共聚物。这些聚合物在水性环境中形成纳米级分子聚集体，具有疏水内部，能够溶解不溶于水的有机化合物，如药物、维生素、染料和成像剂。这些聚合物可选择性地具有反应性功能基团，提供与抗体、配体和其他靶向基团的结合点，有助于药物和成像剂的靶向传递。
• ISOTHIAZOLINE DERIVATIVES AS INSECTICIDAL COMPOUNDS
  申请人：Cassayre Jerome Yves

  公开号：US20140378415A1

  公开（公告）日：2014-12-25

  The present invention provides compounds of formula (I) wherein P is P0, heterocyclyl or heterocyclyl substituted by one to five Z formula (II); Y 1 , Y 2 , Y 3 and Y 4 are independently of each other C—H, C—R 5 , or nitrogen; G1 is oxygen or sulfur; X 4 is C 1 -C 8 haloalkyl; R 4 is aryl or aryl substituted by one to five R 9 , or heteroaryl or heteroaryl substituted by one to five R 9 ; and R 1 , R 2 , R 4 , R 5 , R 9 and Z are as defined in the claims. The invention also provides compositions comprising the compounds of formula (I), intermediates useful in the preparation of compounds of formula (I) and methods of using the compounds of formula (I) to control insects, acarines, nematodes or molluscs.

  本发明提供了公式（I）的化合物，其中P是P0、杂环基或杂环基上取代了1-5个Z式（II）；Y1、Y2、Y3和Y4独立地是C-H、C-R5或氮；G1是氧或硫；X4是C1-C8卤代烷基；R4是芳基或取代了1-5个R9的芳基，或杂芳基或取代了1-5个R9的杂芳基；而R1、R2、R4、R5、R9和Z的定义见权利要求。本发明还提供了包含公式（I）化合物的组合物、制备公式（I）化合物的中间体以及使用公式（I）化合物控制昆虫、螨、线虫或软体动物的方法。
• DIHYDROTHIOPHENE DERIVATIVES AS INSECTICIDAL COMPOUNDS
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：US20150272120A1

  公开（公告）日：2015-10-01

  The present invention provides compounds of formula (I) wherein Q is Q1 or Q2 P is P0, heterocyclyl or heterocyclyl substituted by one to five Z; Y 1 , Y 2 , Y 3 and Y 4 are independently of each other C—H, C—R 5 , or nitrogen; G 1 is oxygen or sulfur; R 1 is hydrogen, C 1 -C 8 alkyl, C 1 -C 8 alkoxy-, C 1 -C 8 alkylcarbonyl-, or C 1 -C 8 alkoxycarbonyl-; X 4 is C 1 -C 8 haloalkyl; R 4 is aryl or aryl substituted by one to five R 9 , or heteroaryl or heteroaryl substituted by one to five R 9 ; n is 0, 1 or 2; and Z, R 2 , R 5 and R 9 are as defined in the claims. The invention also provides methods of controlling insects, acarines, nematodes or molluscs comprising applying to a pest, to a locus of a pest, or to a plant susceptible to attack by a pest an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound of formula (I).

  本发明提供了式（I）的化合物，其中Q是Q1或Q2，P是P0，杂环基或杂环基上取代1至5个Z；Y1、Y2、Y3和Y4分别独立地是C-H、C-R5或氮；G1是氧或硫；R1是氢、C1-C8烷基、C1-C8烷氧基、C1-C8烷基羰基或C1-C8烷氧羰基；X4是C1-C8卤代烷基；R4是芳基或芳基上取代1至5个R9，或杂芳基或杂芳基上取代1至5个R9；n为0、1或2；以及Z、R2、R5和R9如权利要求所定义。本发明还提供了一种控制昆虫、螨、线虫或软体动物的方法，包括向害虫、害虫的地点或易受害虫攻击的植物施用式（I）的杀虫、杀螨、杀线虫或杀软体动物有效量的化合物。
• Compositions for targeting macrophages and other CD206 high expressing cells and methods of treating and diagnosis
  申请人：OHIO STATE INNOVATION FOUNDATION

  公开号：US10806803B2

  公开（公告）日：2020-10-20

  Provided are compounds and compositions for targeting macrophages and other CD206 high expressing cells.

  本文提供了用于靶向巨噬细胞和其他 CD206 高表达细胞的化合物和组合物。