甘氨酸己基酯 | 63907-64-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 甘氨酸己基酯
• 英文名称: glycine hexyl ester
• 英文别名: Glycin-hexylester；Aminoessigsaeure-hexylester；Hexyl 2-aminoacetate
• CAS: 63907-64-2
• 化学式: C₈H₁₇NO₂
• 分子量: 159.228
• InChiKey: LNRLFKGMWKRKEJ-UHFFFAOYSA-N

物化性质

• 沸点：
  203.3±13.0 °C(Predicted)
• 密度：
  0.949±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-磺基苯甲酸酐 、 甘氨酸己基酯 在 氯仿 作用下， 生成 (1,1,3-trioxo-3H-1λ⁶-benz[d]isothiazol-2-yl)-acetic acid hexyl ester
  参考文献：
  名称：

  Fly spray

  摘要：

  公开号：

  US02462835A1
• 作为产物：
  描述：

  聚甘氨酸 、 正己醇 在 盐酸 作用下， 生成 甘氨酸己基酯
  参考文献：
  名称：

  Ehrensvaerd; Brandt, Arkiv foer Kemi, 1946, vol. 21 B, # 4, p. 2,6

  摘要：

  DOI：

文献信息

• [EN] ANTIVIRAL PHOSPHODIAMIDE PRODRUGS OF TENOFOVIR<br/>[FR] PROMÉDICAMENTS ANTIVIRAUX DU TÉNOFOVIR À BASE DE PHOSPHODIAMIDE
  申请人：MERCK SHARP & DOHME

  公开号：WO2017100108A1

  公开（公告）日：2017-06-15

  Compounds of Formula I and pharmaceutically acceptable salts and co-crystals thereof are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.

  Formula I的化合物及其药用可接受的盐和共晶物对抑制HIV逆转录酶具有用途。这些化合物也可能对HIV感染的预防或治疗以及AIDS的预防、延迟发病或进展和治疗具有用途。这些化合物及其盐可用作药物组合物的成分，可选择性地与其他抗病毒药物、免疫调节剂、抗生素或疫苗组合使用。
• Regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
  申请人：ALONSO Jorge

  公开号：US20100216988A1

  公开（公告）日：2010-08-26

  The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

  本发明涉及一种用于选择性合成式I化合物的过程，其中R1; R2; R3; R4; J1; J2; J3; J4和G具有声明中所示的含义。本发明提供了一种直接金属，例如钯或铜，催化的、选择性区域的过程，从2-卤代硝基芳烃和N-取代酰胺开始，合成广泛的非对称、多功能的N-取代苯并咪唑或氮杂苯并咪唑式I化合物。
• Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
  申请人：ALONSO Jorge

  公开号：US20100261909A1

  公开（公告）日：2010-10-14

  The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

  本发明涉及一种配合物I的区域选择性合成方法，其中R0; R1; R2; R3; R4; R5; A1; A2; A3; A4，Q和J具有声明中指示的含义。本发明提供了一种直接铜催化的区域选择性方法，可从2-卤代硝基芳烃和N-取代酰胺出发，合成广泛的非对称、多功能N-取代苯并咪唑或氮杂苯并咪唑配合物I。
• Compounds for the capture of carbon dioxide from gaseous mixtures and subsequent release, related process and plant
  申请人：UNIVERSITA DEGLI STUDI DI MILANO-BICOCCA

  公开号：US10143969B2

  公开（公告）日：2018-12-04

  The present invention relates to novel molecules suitable to the use in the separation/removal of carbon dioxide from gaseous mixtures as liquid-phase carbon dioxide absorbers and suitable to allow the subsequent release of the absorbed carbon dioxide in form of different ionic liquids, preferentially a glycine salt with choline hexanoate, ester between glycine and hexanoic alcohol (hexyl glycinate) and glycerol ester with glycine and hexanoic acid. The present invention also relates to a method and a plant for the capture of carbon dioxide from gaseous mixtures by using an absorber for carbon dioxide in liquid phase with a heating jacket.

  本发明涉及适用于从气态混合物中分离/去除二氧化碳的新型分子，作为液相二氧化碳吸收剂，并适用于随后以不同离子液体的形式释放所吸收的二氧化碳，优先选择甘氨酸盐与己酸胆碱、甘氨酸与己醇的酯类（甘氨酸己酯）以及甘氨酸与己酸的甘油酯。本发明还涉及一种利用带有加热套的液相二氧化碳吸收器从气态混合物中捕获二氧化碳的方法和设备。
• Use of glycine and/or glycine derivatives as antibacterial agent against gram negative bacterial pathogens in foods and/or drinks
  申请人：Bontenbal E. W. Edwin

  公开号：US20060127546A1

  公开（公告）日：2006-06-15

  The invention relates to the use of glycine and/or (earth)alkali glycinate salts, ammonium glycinate and/or esters of glycine and C1-C8 alcohols as antibacterial agent against the gram-negative bacterial patogens Escherichia Coli, Enterobacter Sakazakii, Salmonella, and Campylobacter in foods and/or drinks with the proviso that in addition to said glycine and/or glycine derivative no hetero-saccharide containing macromolecule is used, nor 1,5 D-anhydrofructose is used as antibacterial agent in said foods and drinks. Preferably glycine and/or or (earth)alkali glycinate salts, ammonium glycinate and/or esters of glycine and C1-C8 alcohols are used as sole antibacterial agent in foods and/or drinks.

  本发明涉及使用甘氨酸和/或（土）碱甘氨酸盐、甘氨酸铵和/或甘氨酸和 C1-C8 醇的酯作为抗菌剂来对付革兰氏阴性细菌病原体 大肠杆菌、阪崎肠杆菌、沙门氏菌、 和 弯曲杆菌 在食品和/或饮料中使用，但除上述甘氨酸和/或甘氨酸衍生物外，不得使用含有杂糖的大分子，也不得使用 1,5 D-脱水果糖作为上述食品和饮料中的抗菌剂。甘氨酸和/或（土）碱甘氨酸盐、甘氨酸铵和/或甘氨酸和 C1-C8 脂肪醇的酯最好用作食品和/或饮料中唯一的抗菌剂。