2-溴-3-甲氧基-4-吡啶甲醛 | 191418-78-7

• 物质功能分类: 医药中间体 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-溴-3-甲氧基-4-吡啶甲醛
• 中文别名: 2-溴-3-甲氧基吡啶-4-甲醛
• 英文名称: 2-Bromo-3-methoxyisonicotinaldehyde
• 英文别名: 2-bromo-3-methoxypyridine-4-carbaldehyde
• CAS: 191418-78-7
• 化学式: C₇H₆BrNO₂
• 分子量: 216.03
• InChiKey: NESGFHKARGFUQK-UHFFFAOYSA-N

物化性质

• 沸点：
  316.4±37.0 °C(Predicted)
• 密度：
  1.606±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933399090
• WGK Germany：
  3
• 包装等级：
  III
• 危险类别：
  8
• 危险性防范说明：
  P264,P270,P280,P301+P312+P330,P305+P351+P338+P310,P501
• 危险品运输编号：
  1759
• 危险性描述：
  H302,H318

文献信息

• SUBSTITUTED OXINDOL DERIVATIVES, MEDICAMENTS CONTAINING SAID DERIVATIVES AND USE THEREOF
  申请人：Oost Thorsten

  公开号：US20100273766A1

  公开（公告）日：2010-10-28

  The invention relates to novel oxindole derivatives of general formula (I), wherein the substituents R 1 , R 2 , A, B, and Y are defined as in claim 1 . The invention further relates to medicaments containing said derivatives, and use thereof for the prevention and/or treatment of vasopressin-dependent diseases.

  本发明涉及一种新型的氧化吲哚衍生物，其一般式为(I)，其中取代基R1、R2、A、B和Y的定义如权利要求书所述。本发明还涉及含有该衍生物的药物以及其用于预防和/或治疗利尿激素依赖性疾病的用途。
• SUBSTITUTED OXINDOLE DERIVATIVES, DRUGS CONTAINING SAID DERIVATIVES AND THE USE THEREOF
  申请人：Oost Thorsten

  公开号：US20110071132A1

  公开（公告）日：2011-03-24

  The invention relates to novel oxindol derivative of general formula (I), wherein substituents R 1 , R 2 , A, B and Y are such as defined in a claim 1 . Drugs containing said derivatives and the use thereof for preventing and/or treating vassopress- and/or oxytocin-dependent-diseases are also disclosed.

  本发明涉及一种新的氧化吲哚衍生物，其一般式为（I），其中取代基R1，R2，A，B和Y如权利要求1所定义。还公开了含有该衍生物的药物以及其用于预防和/或治疗压力素和/或催产素依赖性疾病的用途。
• SUBSTITUTED OXINDOLE DERIVATIVES, MEDICAMENTS CONTAINING SAID DERIVATIVES AND USE THEREOF
  申请人：Oost Thorsten

  公开号：US20130029966A1

  公开（公告）日：2013-01-31

  The invention relates to novel oxindole derivatives of general formula (I), wherein the substituents R 1 , R 2 , A, B, and Y are defined as in Claim 1 . The invention further relates to medicaments containing said derivatives, and use thereof for the prevention and/or treatment of vasopressin-dependent diseases.

  本发明涉及一种一般式（I）的新型噁唑啉衍生物，其中取代基R1、R2、A、B和Y的定义如权利要求书所述。本发明还涉及含有该衍生物的药物以及其用于预防和/或治疗利尿激素依赖性疾病的用途。
• SUBSTITUTED OXINDOLE COMPOUNDS
  申请人：Geneste Herve'

  公开号：US20100286165A1

  公开（公告）日：2010-11-11

  The present invention relates to compounds of the general formula (I) in which A, B, R 1 , R 2 and Het have the meaning given in claim 1; Y is a bivalent group of the formula in which D is C 1 -C 3 -alkylene, where D may have a substituent R 5 ; R 3 is hydrogen, C 1 -C 8 -alkyl or together with R 4 is C 1 -C 3 -alkylene which may have a radical R 5a , or together with R 5 is C 1 -C 3 -alkylene, and R 4 is hydrogen, C 1 -C 8 -alkyl or together with R 3 is C 1 -C 3 -alkylene which may have a radical R 5a , or together with R 5 is C 1 -C 3 -alkylene, where R 5 together with R 5a , where present, are a bond or C 1 -C 3 -alkylene; and where one of the following conditions is satisfied: R 3 together with R 4 is C 1 -C 3 -alkylene which may have a radical R 5a ; or R 3 together with R 5 is C 1 -C 3 -alkylene; or R 4 together with R 5 is C 1 -C 3 -alkylene where the radical A is different from phenyl when the radical B is phenyl or naphthyl; and medicaments which comprise such compounds and the use thereof for the prophylaxis and/or treatment of vasopressin-dependent and/or oxytocin-dependent diseases.

  本发明涉及通式（I）的化合物，其中A、B、R1、R2和Het的含义如权利要求1所述；Y是式中的双价基团，其中D是C1-C3-烷基，D可以具有取代基R5；R3是氢、C1-C8-烷基或与R4一起是C1-C3-烷基，该烷基可以具有基团R5a，或与R5一起是C1-C3-烷基，R4是氢、C1-C8-烷基或与R3一起是C1-C3-烷基，该烷基可以具有基团R5a，或与R5一起是C1-C3-烷基，其中R5和R5a（如存在）一起是键或C1-C3-烷基；并且满足以下条件之一：R3与R4一起是可以具有基团R5a的C1-C3-烷基；或R3与R5一起是C1-C3-烷基；或R4与R5一起是C1-C3-烷基，其中当基团B为苯基或萘基时，基团A与苯基不同；以及包含这种化合物的药物以及其用于预防和/或治疗利尿激素依赖性和/或催产素依赖性疾病的用途。
• Substituted Oxindole Derivatives, Drugs Containing Said Derivatives and the Use Thereof
  申请人：Oost Thorsten

  公开号：US20090163492A1

  公开（公告）日：2009-06-25

  The invention relates to novel oxindol derivative of general formula (I), wherein substituents R 1 , R 2 , A, B and Y are such as defined in a claim 1 . Drugs containing said derivatives and the use thereof for preventing and/or treating vassopress- and/or oxytocin-dependent-diseases are also disclosed.

  本发明涉及一种新型的氧化吲哚衍生物，其一般式为(I)，其中取代基R1、R2、A、B和Y如权利要求书中所定义。本发明还揭示了含有该衍生物的药物及其用于预防和/或治疗依赖于血管加压素和/或催产素的疾病的用途。