4-methyl-N-[4-[(4-methylphenyl)sulfonyl-prop-2-enylamino]cyclopent-2-en-1-yl]-N-prop-2-enylbenzenesulfonamide | 208249-61-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-N-[4-[(4-methylphenyl)sulfonyl-prop-2-enylamino]cyclopent-2-en-1-yl]-N-prop-2-enylbenzenesulfonamide
• CAS: 208249-61-0
• 化学式: C₂₅H₃₀N₂O₄S₂
• 分子量: 486.656
• InChiKey: QNHMZIHUQNHKRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  91.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-methyl-N-[4-[(4-methylphenyl)sulfonyl-prop-2-enylamino]cyclopent-2-en-1-yl]-N-prop-2-enylbenzenesulfonamide 在 Grubbs catalyst first generation 作用下， 以 苯 为溶剂， 反应 1.0h， 以76%的产率得到1-(4-Methylphenyl)sulfonyl-2-[[1-(4-methylphenyl)sulfonyl-2,5-dihydropyrrol-2-yl]methyl]-2,5-dihydropyrrole
  参考文献：
  名称：

  Ruthenium-Catalyzed Polycyclization Reactions

  摘要：

  The application of ruthenium alkylidenes such as 1 to the catalysis of polycyclization reactions is reported. Several acyclic precursors have been synthesized and reacted with 1. These precursors vary in topology and contain acetylenic and/or cycloolefinic metathesis relays. The cyclization reactions proceed in moderate to good yields to produce polycyclic polyenes when the precursors are subjected to catalytic amounts of 1. In general, precursors bearing n relay units generate polycycles containing (n + 1) rings.

  DOI：

  10.1021/jo972279g
• 作为产物：
  描述：

  6-噁双环[3.1.0]-3-己烯 在 吡啶 、 苯磺酰胺 、 tris(dibenzylideneacetone)dipalladium(0) chloroform complex 、 N,O-双三甲硅基乙酰胺 、 氯甲酸甲酯 、 三苯基膦 、 1,2-双(二苯基膦)乙烷 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 4-methyl-N-[4-[(4-methylphenyl)sulfonyl-prop-2-enylamino]cyclopent-2-en-1-yl]-N-prop-2-enylbenzenesulfonamide
  参考文献：
  名称：

  Ruthenium-Catalyzed Polycyclization Reactions

  摘要：

  The application of ruthenium alkylidenes such as 1 to the catalysis of polycyclization reactions is reported. Several acyclic precursors have been synthesized and reacted with 1. These precursors vary in topology and contain acetylenic and/or cycloolefinic metathesis relays. The cyclization reactions proceed in moderate to good yields to produce polycyclic polyenes when the precursors are subjected to catalytic amounts of 1. In general, precursors bearing n relay units generate polycycles containing (n + 1) rings.

  DOI：

  10.1021/jo972279g

文献信息

• Ruthenium-Catalyzed Polycyclization Reactions
  作者：William J. Zuercher、Matthias Scholl、Robert H. Grubbs

  DOI：10.1021/jo972279g

  日期：1998.6.1

  The application of ruthenium alkylidenes such as 1 to the catalysis of polycyclization reactions is reported. Several acyclic precursors have been synthesized and reacted with 1. These precursors vary in topology and contain acetylenic and/or cycloolefinic metathesis relays. The cyclization reactions proceed in moderate to good yields to produce polycyclic polyenes when the precursors are subjected to catalytic amounts of 1. In general, precursors bearing n relay units generate polycycles containing (n + 1) rings.