1-(4-(4'-methoxyphenyl)benzoyl)-5-methoxy-2-methylindole-3-acetic acid 4-pentenyl ester | 1019777-24-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-(4-(4'-methoxyphenyl)benzoyl)-5-methoxy-2-methylindole-3-acetic acid 4-pentenyl ester
• 英文别名: Pent-4-enyl 2-[5-methoxy-1-[4-(4-methoxyphenyl)benzoyl]-2-methylindol-3-yl]acetate；pent-4-enyl 2-[5-methoxy-1-[4-(4-methoxyphenyl)benzoyl]-2-methylindol-3-yl]acetate
• CAS: 1019777-24-2
• 化学式: C₃₁H₃₁NO₅
• 分子量: 497.591
• InChiKey: WLOMQHGBPHGJPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  37
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  66.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  pent-4-en-1-yl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate 、 4-甲氧基苯硼酸 在 dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) 、 三乙胺 作用下， 以 水 为溶剂， 反应 24.0h， 以86%的产率得到1-(4-(4'-methoxyphenyl)benzoyl)-5-methoxy-2-methylindole-3-acetic acid 4-pentenyl ester
  参考文献：
  名称：

  Room-Temperature Suzuki−Miyaura Couplings in Water Facilitated by Nonionic Amphiphiles

  摘要：

  Use of a dilute aqueous solution containing a nonionic amphiphile allows efficient Suzuki-Miyaura cross-couplings of arylboronic acids with a wide array of aryl halides and pseudohalides, including sterically hindered and lipophilic substrates, in most cases at room temperature.

  DOI：

  10.1021/ol702714y

文献信息

• Room-Temperature Suzuki−Miyaura Couplings in Water Facilitated by Nonionic Amphiphiles
  作者：Bruce H. Lipshutz、Tue B. Petersen、Alexander R. Abela

  DOI：10.1021/ol702714y

  日期：2008.4.1

  Use of a dilute aqueous solution containing a nonionic amphiphile allows efficient Suzuki-Miyaura cross-couplings of arylboronic acids with a wide array of aryl halides and pseudohalides, including sterically hindered and lipophilic substrates, in most cases at room temperature.