N-acetyl-L-cysteine hydrochloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-acetyl-L-cysteine hydrochloride
• 英文别名: acetyl-cysteine-HCl；(2R)-2-acetamido-3-sulfanylpropanoic acid;hydron;chloride
• 化学式: C₅H₉NO₃S*ClH
• 分子量: 199.658
• InChiKey: BNAZKIJXZHLHTG-WCCKRBBISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.07
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  67.4
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  三苯基甲醇 、 N-acetyl-L-cysteine hydrochloride 生成 N-乙酰基-S-三苯甲基-L-半胱氨酸
  参考文献：
  名称：

  实验性抗白血病药物。S-三苯甲基半胱氨酸及相关化合物的制备及结构活性研究。

  摘要：

  DOI：

  10.1021/jm00297a019

文献信息

• Flüssige Diclofenac-Zubereitungen
  申请人：Merckle GmbH

  公开号：EP0185374A2

  公开（公告）日：1986-06-25

  Es werden wässrige, stabile, relativ konzentrierte Lösungen von Diclofenac, die eine Mischung von Propylenglykol und Polyethylenglykol in definierten Mengenverhältnissen enthalten, offenbart. Vorzugsweise enthalten die Lösungen ein Lokalanästhetikum wie Lidocain und ein Reduktionsmittel als Stabilisator.

  本发明公开了双氯芬酸的稳定、相对浓缩的水溶液，其中含有规定比例的丙二醇和聚乙二醇混合物。 溶液最好含有局部麻醉剂，如利多卡因和作为稳定剂的还原剂。
• Hair treatment composition
  申请人：KAO CORPORATION

  公开号：EP0472858A2

  公开（公告）日：1992-03-04

  A hair treatment composition which comprises a specific silicone compound and a specific penetration accelerator and the pH value thereof is adjusted within a specific range at the use of the composition is disclosed. A hair treatment composition which comprises the specific silicone compound, the specific penetration accelerator and an oxidizing agent is also disclosed. The hair treatment composition of the present invention can exert an effect of preventing hair from causing a split hair and an effect of improving hair gloss, which can sustain for a long time, on the hair. Further, a cyclic Bunte salt-modified silicone which is useful as a conditioning component of a hair treatment composition, and hair treatment compositions comprising the same are disclosed.

  本发明公开了一种头发治疗组合物，该组合物由特定硅化合物和特定渗透促进剂组成，在使用该组合物时，其 pH 值在特定范围内进行调节。本发明还公开了一种头发治疗组合物，该组合物由特定硅氧烷化合物、特定渗透促进剂和氧化剂组成。本发明的头发处理组合物可以发挥防止头发分叉的效果和提高头发光泽度的效果，并能长期保持。此外，本发明还公开了一种可用作头发护理组合物的调理成分的环丁基盐改性硅氧烷，以及包含该硅氧烷的头发护理组合物。
• Stable oxidative colouring composition for keratin fibers
  申请人：KPSS-Kao Professional Salon Services GmbH

  公开号：EP2422762A1

  公开（公告）日：2012-02-29

  Present invention relates to a stable oxidative colouring composition for keratin fibres. The aim of the inventors has been to find out an antioxidant system which is alternative to the sodium sulphite - ascorbic acid and/or its salts combination. It is furthermore the aim of the present invention that using the antioxidant system of the present invention, intensive oxidative colouration is achieved after storing said composition for a substantially long period of time. Accordingly, the object of the present invention is an oxidative dyeing composition based on at least ole oxidative dye precursor comprising further at least two structurally different reducing agents wherein the first one is selected from inorganic reducing agents and the second is an organic reducing agent and/or its salts wherein the composition is substantially free of ascorbic acid and/or its salts.

  本发明涉及一种用于角蛋白纤维的稳定氧化着色组合物。发明者的目的是找到一种可替代亚硫酸钠-抗坏血酸和/或其盐组合的抗氧化剂体系。此外，本发明的目的还在于，使用本发明的抗氧化剂体系，在所述组合物储存相当长一段时间后，可实现强化氧化着色。因此，本发明的目的是一种基于至少一种氧化染料前体的氧化染色组合物，该组合物进一步包含至少两种结构不同的还原剂，其中第一种选自无机还原剂，第二种是有机还原剂和/或其盐类，其中该组合物基本上不含抗坏血酸和/或其盐类。
• Aqueous formulation comprising paracetamol and ibuprofen
  申请人：HYLORIS PHARMACEUTICALS SA

  公开号：US11219609B2

  公开（公告）日：2022-01-11

  The present invention relates to an aqueous ibuprofen and paracetamol composition of pH 6.3-7.3 and to its use. The present invention relates to a method for preparing a combination product of ibuprofen and paracetamol. It also relates to the compositions for use as a medicament, especially for the treatment of pain and/or inflammation; especially for administration of the composition by intravenous injection.

  本发明涉及一种 pH 值为 6.3-7.3 的布洛芬和扑热息痛水溶液组合物及其用途。本发明涉及布洛芬和扑热息痛复方制剂的制备方法。本发明还涉及用作药物的组合物，特别是用于治疗疼痛和/或炎症；尤其是通过静脉注射给药。
• Synthesis, in vitro, and in vivo antibacterial activity of nocathiacin I thiol-Michael adducts
  作者：B. Narasimhulu Naidu、Margaret E. Sorenson、Joanne J. Bronson、Michael J. Pucci、Junius M. Clark、Yasutsugu Ueda

  DOI：10.1016/j.bmcl.2005.02.046

  日期：2005.4

  The synthesis and antibacterial activity of a series of nocathiacin I derivatives (4-20) containing polar water solubilizing groups is described. Thiol-Michael adducts containing acidic polar groups have reduced antibacterial activity whereas those with basic polar groups have retained very good antibacterial activity. (c) 2005 Elsevier Ltd. All rights reserved.