(3,4-dithia-hexanediyldiimino)-tetra-acetic acid | 64381-91-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3,4-dithia-hexanediyldiimino)-tetra-acetic acid
• 英文别名: Bis-[2-(bis-carboxymethyl-amino)-aethyl]-disulfid；(3,4-Dithia-hexandiyldiimino)-tetra-essigsaeure；N,N,N',N'-Tetra-carboxymethyl-cystamin；Cystamin-tetraessigsaeure；2-[2-[2-[Bis(carboxymethyl)amino]ethyldisulfanyl]ethyl-(carboxymethyl)amino]acetic acid
• CAS: 64381-91-5
• 化学式: C₁₂H₂₀N₂O₈S₂
• 分子量: 384.431
• InChiKey: NCLFHODVXHJYEO-UHFFFAOYSA-N

物化性质

• 熔点：
  186-188 °C
• 沸点：
  686.2±55.0 °C(Predicted)
• 密度：
  1.552±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -5.2
• 重原子数：
  24
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  206
• 氢给体数：
  4
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  Ethyl 2-[2-[2-[bis(2-ethoxy-2-oxoethyl)amino]ethyldisulfanyl]ethyl-(2-ethoxy-2-oxoethyl)amino]acetate 在 sodium hydroxide 、 水 作用下， 以 甲醇 为溶剂， 反应 24.0h， 生成 (3,4-dithia-hexanediyldiimino)-tetra-acetic acid
  参考文献：
  名称：

  Dumbbell-like Au−Fe₃O₄ Nanoparticles for Target-Specific Platin Delivery

  摘要：

  Dumbbeil-like Au-Fe3O4 nanoparticles (NPs) were made and coupled with Herceptin and a platin complex. The ptatin-Au-Fe3O4-Herceptin NPs act as a target-specific nanocarriers for delivery of platin into Her2-positive breast cancer cells (Sk-Br3) with strong therapeutic effects. The conjugate has a half-maximal inhibitory concentration (IC50) toward Sk-Br3 cells of 1.76 mu g of Pt/mL, which is lower than that needed for cisplatin (3.5 mu g/mL). The work demonstrates that the dumbbell-like Au-Fe3O4 NPs are promising nanocarriers for highly sensitive diagnostic and therapeutic applications.

  DOI：

  10.1021/ja900790v

文献信息

• Komplexone XXIX. Ein grosser Chelateffekt besonderer Art
  作者：G. Schwarzenbach、H. Senn、G. Anderegg

  DOI：10.1002/hlca.19570400640

  日期：——

  Complexing agents of the type: (HOOCCH2)(2=N(CH2))n N = (CH2COOH)2 with n-values from 2–8 have been investigated. The stability constants of the 1:1 complexes of Ca2+, Cd2+ and Hg2+ have been determined for nearly the whole series of these complexons and a few values have been obtained also for the complexes of Mg2+, Sr2+, Ba2+ and Go2+. There is generally a strong decrease in complex stability when

  研究了以下类型的络合剂：（HOOCCH 2）（2 = N（CH 2））n N =（CH 2 COOH）2，其n值为2-8。Ca 2 +，Cd 2+和Hg 2+的1：1配合物的稳定常数几乎已针对这些配合物的整个系列确定，并且Mg 2+的配合物也获得了一些值， Sr 2 +，Ba 2+和Go 2+。当n从2增加到4时，络合物的稳定性通常会大大降低，此时达到一个几乎恒定的值，随着链长11的进一步增加，该值不再有明显的变化。汞络合物的表现异常出色。如果可以通过该杂原子的配位形成新的5元螯合环，则用O，S和N（CH 2）取代连接两个氮的链中的一个或两个CH 2基团，将在很大程度上提高复合物的稳定性。
• Felder; Bianchi, Farmaco, Edizione Scientifica, 1954, vol. 9, p. 708,712
  作者：Felder、Bianchi

  DOI：——

  日期：——
• CHIOTELLIS, E.;STASSINOPOULOU, C. I.;VARVARIGOU, A.;VAVOURAKI, H., J. MED. CHEM., 1982, 25, N 11, 1370-1374
  作者：CHIOTELLIS, E.、STASSINOPOULOU, C. I.、VARVARIGOU, A.、VAVOURAKI, H.

  DOI：——

  日期：——
• Dumbbell-like Au−Fe₃O₄ Nanoparticles for Target-Specific Platin Delivery
  作者：Chenjie Xu、Baodui Wang、Shouheng Sun

  DOI：10.1021/ja900790v

  日期：2009.4.1

  Dumbbeil-like Au-Fe3O4 nanoparticles (NPs) were made and coupled with Herceptin and a platin complex. The ptatin-Au-Fe3O4-Herceptin NPs act as a target-specific nanocarriers for delivery of platin into Her2-positive breast cancer cells (Sk-Br3) with strong therapeutic effects. The conjugate has a half-maximal inhibitory concentration (IC50) toward Sk-Br3 cells of 1.76 mu g of Pt/mL, which is lower than that needed for cisplatin (3.5 mu g/mL). The work demonstrates that the dumbbell-like Au-Fe3O4 NPs are promising nanocarriers for highly sensitive diagnostic and therapeutic applications.