N-(3-Amino-phenyl)-phthalimid | 32338-22-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-(3-Amino-phenyl)-phthalimid
• 英文别名: 2-(3-aminophenyl)isoindoline-1,3-dione；2-(3-aminophenyl)-2,3-dihydro-1H-isoindole-1,3-dione；2-(3-aminophenyl)isoindole-1,3-dione
• CAS: 32338-22-0
• 化学式: C₁₄H₁₀N₂O₂
• mdl: MFCD00441116
• 分子量: 238.246
• InChiKey: OOPLRJVJUNAQIG-UHFFFAOYSA-N

物化性质

• 熔点：
  244-246 °C
• 沸点：
  480.5±47.0 °C(Predicted)
• 密度：
  1.409±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(3-Amino-phenyl)-phthalimid 在 氢氧化钾 、 溶剂黄146 、 甲胺 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 为溶剂， 反应 38.0h， 生成 2-[3-(2-amino-phenylazo)-phenylazo]aniline
  参考文献：
  名称：

  Helical Conformational Dynamics and Photoisomerism of Alternating Pyridinedicarboxamide/m-(Phenylazo)azobenzene Oligomers

  摘要：

  Alternating sequences of pyridine-2,6-dicarboxamides and meta-(phenylazo)azobenzenes have been assembled into oligomers composed of four (8) and eight (9) azobenzene linkages. X-ray crystallography confirmed that oligomer 8 adopts a two-turn helical conformation with a helical pitch of approximately 3.4 angstrom in the solid state. The presence of a two- and four-turn helical conformation of 8 and 9, respectively, in polar and nonpolar solvents was elucidated by the anisotropic upfield shifting of protons located within the helices, NOE enhancements between protons oriented toward the helix interior, and the diastereotopicity of the terminal benzyloxycarbonyl (CBz) methylene protons. H-1 NMR line shape analysis of the CBz methylene hydrogens at the chain ends revealed a dynamic equilibria interconverting M and P helical conformations with energetic barriers (Delta G(double dagger)) of 11.1 (AS(double dagger) = -19.4 +/- 1.6 cal mol(-1) K-1; Delta H-double dagger = 6.5 +/- 0.4 kcal/mol) for 8 and 13.8 kcal/mol (Delta S-double dagger = -6.6 +/- 6.2 cal mol(-1) K-1; Delta H-double dagger = 11.8 +/- 1.8 kcal/mol) for 9. Irradiation of the oligomers with 350 nm light induces an E -> Z isomerization of the azo linkages that decreases in efficacy at longer helix lengths. The suppression of E -> Z isomerization is a consequence of the contrasting behavior of the azo linkages located at the helix termini, which afford Z/E ratios similar to those of model compound 7d, and the internal azo groups, which undergo significantly lower Z/E conversion ratios compared with 7e.

  DOI：

  10.1021/ja0547228
• 作为产物：
  描述：

  2-(2-羟基苯基)异吲哚-1,3-二酮 在 全氟丁基磺酰氟 、 三(三甲基硅)胺 、 双(三甲基硅烷基)氨基钾 、 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 5.08h， 以44%的产率得到N-(3-Amino-phenyl)-phthalimid
  参考文献：
  名称：

  一锅苯酚生成苯甲酰苯：通过苯酚的脱氧胺化作用形成初级苯胺。

  摘要：

  由苯酚选择性地原位生成苯并在酸性处理后被六甲基二硅氮合钾区域选择性地捕获以形成伯苯胺。酚羟基直接转化为游离氨基是用于制备伯芳基胺的有用方法，该伯芳基胺难以使用涉及苯酚衍生物与氨的偶联反应来合成。虽然邻位和间位取代的苯酚的反应仅产生间位取代的苯胺，但对位取代的苯酚的反应提供了邻位甲硅烷基苯胺。

  DOI：

  10.1002/chem.201904987

文献信息

• [EN] METHODS AND COMPOSITIONS FOR TARGETED THERAPEUTICS<br/>[FR] MÉTHODES ET COMPOSITIONS POUR UN USAGE THÉRAPEUTIQUE CIBLÉ
  申请人：MEDIVATION TECHNOLOGIES INC

  公开号：WO2017019830A1

  公开（公告）日：2017-02-02

  This disclosure describes compositions and methods for delivering and localizing repair cells to therapeutic targets.

  这份披露描述了将修复细胞传递和定位到治疗靶点的组合物和方法。
• [EN] METHODS AND COMPOSITIONS FOR TARGETED THERAPEUTICS<br/>[FR] MÉTHODES ET COMPOSITIONS POUR UNE THÉRAPEUTIQUE CIBLÉE
  申请人：MEDIVATION TECHNOLOGIES INC

  公开号：WO2017019817A1

  公开（公告）日：2017-02-02

  This disclosure describes compositions and methods for delivering and localizing repair cells to therapeutic targets.

  这份披露描述了将修复细胞传递和定位到治疗靶点的组合物和方法。
• [EN] PELLET COMPOSITION CONTAINING REPAIR CELLS<br/>[FR] COMPOSITION AGGRÉGÉE CONTENANT DES CELLULES RÉPARATRICES
  申请人：MEDIVATION TECHNOLOGIES INC

  公开号：WO2017019822A1

  公开（公告）日：2017-02-02

  This disclosure describes compositions and methods for delivering and localizing repair cells, such as mesenchymal stem cells (MSCs) to the sites of tissue injuries, including cartilage injuries. This disclosure also describes methods for chondrogenic differentiation of MSCs in pellet compositions.

  这份披露描述了用于传递和定位修复细胞的组合物和方法，例如间充质干细胞（MSCs），到组织损伤部位，包括软骨损伤。这份披露还描述了在颗粒组合物中进行MSCs软骨发生分化的方法。
• METHOD OF MANUFACTURING BIPYRIDINIUM COMPOUND AND SYNTHETIC INTERMEDIATE OF THE SAME, METHOD OF MANUFACTURING DYE COMPOUND, AND NOVEL BIPYRIDINIUM COMPOUND AND NOVEL DYE COMPOUND COMPRISING THE SAME
  申请人：Nii Kazumi

  公开号：US20090082570A1

  公开（公告）日：2009-03-26

  Provided is a method of manufacturing a bipyridinium compound denoted by general formula (A). In general formula (A), Ar 1 and Ar 2 each independently denote an optionally substituted (hetero)aryl group, R 3 and R 4 each independently denote a substituent that may form a ring with a pyridine ring to which the substituent substitutes, m3 and m4 each independently denote an integer ranging from 0 to 4, X denotes a halogen atom or RSO 3 , and R denotes an optionally substituted aryl group or alkyl group. The method can manufacture a 4,4′-bipyridinium compound under mild reaction conditions in an integrated manner without separation of intermediates.

  提供了一种制造双吡啶化合物的方法，其通用式为(A)。在通用式(A)中，Ar1和Ar2分别独立表示可选择取代的(杂)芳基团，R3和R4分别独立表示可与取代基形成环的基团，m3和m4分别独立表示范围从0到4的整数，X表示卤原子或RSO3，R表示可选择取代的芳基团或烷基团。该方法可以在温和的反应条件下以一体化方式制造4,4'-双吡啶化合物，无需中间体的分离。
• Biedermann, Chemische Berichte, 1877, vol. 10, p. 1163
  作者：Biedermann

  DOI：——

  日期：——