(Z)-2-(2-(pyridin-4-yl)vinylthio)aniline | 1088706-79-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (Z)-2-(2-(pyridin-4-yl)vinylthio)aniline
• CAS: 1088706-79-9
• 化学式: C₁₃H₁₂N₂S
• 分子量: 228.318
• InChiKey: OHAMRTWVZXBQIV-YFHOEESVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.43
• 重原子数：
  16.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.91
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  4-乙炔基吡啶 、 双(2-氨基苯基)二硫 在 copper(l) iodide 、 rongalite 、 caesium carbonate 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以14%的产率得到(Z)-2-(2-(pyridin-4-yl)vinylthio)aniline
  参考文献：
  名称：

  Hydrothiolation of terminal alkynes with diaryl disulfides and diphenyl diselenide: selective synthesis of (Z)-1-alkenyl sulfides and selenides

  摘要：

  A simple, stereoselective and efficient method for the hydrothiolation of terminal alkynes with diaryl disulfides and diphenyl diselenide has been developed. In the presence of Cul, rongalite, and Cs2CO3, a variety Of disulfides Underwent the reaction of terminal alkynes stereoselectively to afford the corresponding (Z)-1-alkenyl sulfides in moderate to excellent yields. it is noteworthy that hydroselenations of 1,2-diphenyldiselane with alkynes are also conducted smoothly to afford (Z)-1-alkenyl selenides in good yields under the standard conditions. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.09.022

文献信息

• Hydrothiolation of terminal alkynes with diaryl disulfides and diphenyl diselenide: selective synthesis of (Z)-1-alkenyl sulfides and selenides
  作者：Zhang-Lin Wang、Ri-Yuan Tang、Pei-Song Luo、Chen-Liang Deng、Ping Zhong、Jin-Heng Li

  DOI：10.1016/j.tet.2008.09.022

  日期：2008.11

  A simple, stereoselective and efficient method for the hydrothiolation of terminal alkynes with diaryl disulfides and diphenyl diselenide has been developed. In the presence of Cul, rongalite, and Cs2CO3, a variety Of disulfides Underwent the reaction of terminal alkynes stereoselectively to afford the corresponding (Z)-1-alkenyl sulfides in moderate to excellent yields. it is noteworthy that hydroselenations of 1,2-diphenyldiselane with alkynes are also conducted smoothly to afford (Z)-1-alkenyl selenides in good yields under the standard conditions. (C) 2008 Elsevier Ltd. All rights reserved.