N-[4-chloro-3-(trifluoromethyl)phenyl]-4-methyl-3-(2-pyridin-3-yl-1H-imidazol-5-yl)benzamide | 1098102-35-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-chloro-3-(trifluoromethyl)phenyl]-4-methyl-3-(2-pyridin-3-yl-1H-imidazol-5-yl)benzamide
• CAS: 1098102-35-2
• 化学式: C₂₃H₁₆ClF₃N₄O
• 分子量: 456.854
• InChiKey: DGWZVQOJYIINIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  70.7
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-methyl-3-[2-(3-pyridinyl)-1H-imidazol-5-yl]benzoic acid 、 2-氯-5-氨基三氟甲苯 在 三乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 N-[4-chloro-3-(trifluoromethyl)phenyl]-4-methyl-3-(2-pyridin-3-yl-1H-imidazol-5-yl)benzamide
  参考文献：
  名称：

  [EN] ANTIPROLIFERATIVE COMPOUNDS BASED ON 5-MEMBERED HETEROCYCLES
  [FR] NOUVEAUX COMPOSÉS CHIMIQUES

  摘要：

  公开号：

  WO2009003998A3

文献信息

• CHEMICAL COMPOUNDS
  申请人：Sapountzis Ioannis

  公开号：US20100240657A1

  公开（公告）日：2010-09-23

  The present invention encompasses compounds of general formula (1) wherein the groups R 2 to R 4 , L, Q and n are defined as in claim 1 , which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition with the above-mentioned properties.
• [EN] NEW CHEMICAL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS CHIMIQUES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2009003998A2

  公开（公告）日：2009-01-08

  The present invention encompasses compounds of general formula (1) wherein the groups R2 to R4, L, Q and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition with the above-mentioned properties.
• [EN] ANTIPROLIFERATIVE COMPOUNDS BASED ON 5-MEMBERED HETEROCYCLES<br/>[FR] NOUVEAUX COMPOSÉS CHIMIQUES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2009003998A3

  公开（公告）日：2009-02-26