6-(5-chloro-2-hydroxyphenyl)-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile | 925006-65-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-(5-chloro-2-hydroxyphenyl)-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
• 英文别名: 6-(5-Chloro-2-hydroxyphenyl)-2-hydroxy-4-methylpyridine-3-carbonitrile；6-(5-chloro-2-hydroxyphenyl)-4-methyl-2-oxo-1H-pyridine-3-carbonitrile
• CAS: 925006-65-1
• 化学式: C₁₃H₉ClN₂O₂
• 分子量: 260.68
• InChiKey: ZNDLTFOSUBNLPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  73.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-氯-2-甲基-4H-苯并吡喃-4-酮 、 氰乙酰胺 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 反应 10.0h， 以69%的产率得到6-(5-chloro-2-hydroxyphenyl)-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
  参考文献：
  名称：

  Reactions of 2-Methylchromones with Cyanoacetamides and Ethyl Cyanoacetate. Synthesis of 6-(2-Hydroxyaryl)-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitriles and 7-Hydroxy-6-imino-9-methyl-6H-benzo[c]chromene-8-carbonitriles

  摘要：

  Although 2‐methylchromones react with cyanoacetamide and N‐methyl cyanoacetamide in the presence of sodium ethoxide in refluxing ethanol to produce 6‐(2‐hydroxyaryl)‐4‐methyl‐2‐oxo‐1,2‐dihydropyridine‐3‐carbonitriles, their reactions with ethyl cyanoacetate under the same conditions took an entirely different course and gave 7‐hydroxy‐6‐imino‐9‐methyl‐6H‐benzo[c]chromene‐8‐carbonitriles.

  DOI：

  10.1002/jhet.1601

文献信息

• Reactions of 2-Methylchromones with Cyanoacetamides and Ethyl Cyanoacetate. Synthesis of 6-(2-Hydroxyaryl)-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitriles and 7-Hydroxy-6-imino-9-methyl-6<i>H</i>-benzo[<i>c</i>]chromene-8-carbonitriles
  作者：Vyacheslav Ya. Sosnovskikh、Viktor A. Anufriev、Alexander V. Safrygin、Oleg S. Eltsov

  DOI：10.1002/jhet.1601

  日期：2013.6

  Although 2‐methylchromones react with cyanoacetamide and N‐methyl cyanoacetamide in the presence of sodium ethoxide in refluxing ethanol to produce 6‐(2‐hydroxyaryl)‐4‐methyl‐2‐oxo‐1,2‐dihydropyridine‐3‐carbonitriles, their reactions with ethyl cyanoacetate under the same conditions took an entirely different course and gave 7‐hydroxy‐6‐imino‐9‐methyl‐6H‐benzo[c]chromene‐8‐carbonitriles.