6-chloro-1,2,4,9-tetrahydrospiro[carbazole-3,3'indolin]-2'-one | 1456718-41-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 6-chloro-1,2,4,9-tetrahydrospiro[carbazole-3,3'indolin]-2'-one
• 英文别名: 6-chlorospiro[1,2,4,9-tetrahydrocarbazole-3,3'-1H-indole]-2'-one
• CAS: 1456718-41-4
• 化学式: C₁₉H₁₅ClN₂O
• 分子量: 322.794
• InChiKey: XBSAJRAFPFSJBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  44.9
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  spiro[cyclohexane-1,3’-indoline]-2’,4-dione 、 对氯苯肼盐酸盐 在 三聚氯氰 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以99%的产率得到6-chloro-1,2,4,9-tetrahydrospiro[carbazole-3,3'indolin]-2'-one
  参考文献：
  名称：

  Mild, efficient Fischer indole synthesis using 2,4,6-trichloro-1,3,5-triazine (TCT)

  摘要：

  Mild and efficient protocol for the Fischer indole synthesis using TCT has been described. TCT serves as a mild and inexpensive catalyst. Under these conditions several functional groups such as ester, cyano, sulfone, amides, and ethers are tolerated. By this method, many functionalized analytically pure indoles were prepared easily without the need of purification. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.07.157

文献信息

• Mild, efficient Fischer indole synthesis using 2,4,6-trichloro-1,3,5-triazine (TCT)
  作者：Eranna Siddalingamurthy、Kittappa M. Mahadevan、Jagadeesh N. Masagalli、Hosanagara N. Harishkumar

  DOI：10.1016/j.tetlet.2013.07.157

  日期：2013.10

  Mild and efficient protocol for the Fischer indole synthesis using TCT has been described. TCT serves as a mild and inexpensive catalyst. Under these conditions several functional groups such as ester, cyano, sulfone, amides, and ethers are tolerated. By this method, many functionalized analytically pure indoles were prepared easily without the need of purification. (C) 2013 Elsevier Ltd. All rights reserved.