N-(2-(diethylamino)ethyl)pentanamide | 100536-61-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-(2-(diethylamino)ethyl)pentanamide
• 英文别名: N-(2-diethylamino-ethyl)-valeramide；N-(2-Diaethylamino-aethyl)-valeramid；Valeramide, N-(2-(diethylamino)ethyl)-；N-[2-(diethylamino)ethyl]pentanamide
• CAS: 100536-61-6
• 化学式: C₁₁H₂₄N₂O
• mdl: MFCD01675649
• 分子量: 200.324
• InChiKey: AEFHIRFDRNSDRY-UHFFFAOYSA-N

物化性质

• 沸点：
  328.1±25.0 °C(Predicted)
• 密度：
  0.897±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.909
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  戊酰氯 、 N,N-二乙基乙二胺 在 碳酸氢钠 作用下， 以 甲醇 为溶剂， 生成 N-(2-(diethylamino)ethyl)pentanamide
  参考文献：
  名称：

  THERMO-RESPONSIVE DRAW SOLUTE FOR FORWARD OSMOSIS AND METHOD FOR WATER DESALINATION AND PURIFICATION USING THE SAME

  摘要：

  本发明涉及一种热响应性抽提溶质，可应用于基于正渗透的水淡化和净化。该热响应性抽提溶质的摩尔质量为50至3000克/摩尔，在0°C至70°C的温度下发生相变。该热响应性抽提溶质为基于正渗透的海水淡化和受污水净化创造了最佳条件。本发明还涉及一种利用热响应性抽提溶质进行水淡化和净化的方法。该方法对水淡化或净化消耗少量能量，简单应用于水淡化或净化，并能够非常容易地分离抽提溶质。

  公开号：

  US20140158621A1

文献信息

• THERMO-RESPONSIVE DRAW SOLUTE FOR FORWARD OSMOSIS AND METHOD FOR WATER DESALINATION AND PURIFICATION USING THE SAME
  申请人：Lee Yan

  公开号：US20140158621A1

  公开（公告）日：2014-06-12

  The present invention relates to a thermo-responsive draw solute that can be applied to water desalination and purification based on forward osmosis. The thermo-responsive draw solute has a molar mass of 50 to 3000 g/mol and undergoes a phase transition at a temperature of 0° C. to 70° C. The thermo-responsive draw solute creates optimum conditions for the desalination of seawater and the purification of contaminated water based on forward osmosis. The present invention also relates to a method for water desalination and purification using the thermo-responsive draw solute. The method consumes little energy for water desalination or purification, is simple to apply to water desalination or purification, and enables separation of the draw solute in a very easy manner.

  本发明涉及一种热响应性抽提溶质，可应用于基于正渗透的水淡化和净化。该热响应性抽提溶质的摩尔质量为50至3000克/摩尔，在0°C至70°C的温度下发生相变。该热响应性抽提溶质为基于正渗透的海水淡化和受污水净化创造了最佳条件。本发明还涉及一种利用热响应性抽提溶质进行水淡化和净化的方法。该方法对水淡化或净化消耗少量能量，简单应用于水淡化或净化，并能够非常容易地分离抽提溶质。
• Polarity-Tuning Derivatization-LC-MS Approach for Probing Global Carboxyl-Containing Metabolites in Colorectal Cancer
  作者：Xiqing Bian、Na Li、Binbin Tan、Baoqing Sun、Ming-Quan Guo、Guoxin Huang、Li Fu、W. L. Wendy Hsiao、Liang Liu、Jian-Lin Wu

  DOI：10.1021/acs.analchem.8b01873

  日期：2018.10.2

  Carboxyl-containing metabolites (CCMs) widely exist in living systems and are the essential components for life. Global characteristics of CCMs in biological samples are critical for the understanding of physiological processes and the discovery for the onset of relevant diseases. However, their determination represents a challenge due to enormous polarity differences, structural diversity, high structural similarity, and poor ionization efficiency in mass spectrometry. Herein, 5-(diisopropylamino)amylamine (DIAAA) derivatization coupled with liquid chromatography–mass spectrometry (LC-MS) was developed for mapping the CCMs. With this methodology, the sensitivity was significantly enhanced. More importantly, the hydrophobicity of polar CCMs, amino acids, TCA cycle intermediates, and short-chain fatty acids and the hydrophilicity of low-polar CCMs, long-chain fatty acids, and bile acids were significantly increased, resulting in a remarkable separation efficiency for which 68 CCMs can be simultaneously determined. Furthermore, the polarity-tuning effect was confirmed to be induced by the different impacts of aliphatic chains and nitrogen atom in DIAAA, the latter existing as a cation in the acidic mobile phase, using different derivatization reagents. Finally, this derivatization method was utilized to hunt for the potential biomarkers in colorectal cancer (CRC) patients and 52 CCMs, related with several key metabolic pathways, including amino acids metabolism, TCA cycle, fatty acid metabolism, pyruvate metabolism, and gut flora metabolism were identified. This innovative polarity-tuning derivatization-LC-MS approach was proved to be a valuable tool for probing global metabolome with high separation efficiency and sensitivity in various biological samples.

  含羧基代谢物（CCMs）广泛存在于生物系统中，是生命的基本组成部分。CCMs在生物样本中的全球特征对于理解生理过程和发现相关疾病的发生具有重要意义。然而，由于极性差异巨大、结构多样性、高结构相似性和在质谱中的离子化效率较低，它们的测定面临挑战。在此，我们开发了5-(二异丙基氨基)戊胺（DIAAA）衍生化结合液相色谱-质谱（LC-MS）的方法以绘制CCMs的分布。通过这种方法，灵敏度显著提高。更重要的是，极性CCMs、氨基酸、TCA循环中间体和短链脂肪酸的疏水性显著增强，而低极性CCMs、长链脂肪酸和胆汁酸的亲水性也显著增加，从而实现了卓越的分离效率，使得68种CCMs可以同时测定。此外，极性调节效应被证实是由于DIAAA中脂肪链和氮原子的不同影响所引起的，后者在酸性流动相中以阳离子的形式存在，使用不同的衍生化试剂。最后，该衍生化方法被用于寻找结直肠癌（CRC）患者的潜在生物标志物，识别出52种与多条关键代谢通路（包括氨基酸代谢、TCA循环、脂肪酸代谢、丙酮酸代谢和肠道菌群代谢）相关的CCMs。这种创新的极性调节衍生化-LC-MS方法被证明是探测各种生物样本全球代谢组的高分离效率和灵敏度的有价值工具。
• Boissier et al., Therapie, 1957, vol. 12, p. 551,552,555
  作者：Boissier et al.

  DOI：——

  日期：——
• IMIDAZO[1,2-A]PYRIDINE DERIVATIVES: PREPARATION AND PHARMACEUTICAL APPLICATIONS
  申请人：Lee C. Ken

  公开号：US20080085896A1

  公开（公告）日：2008-04-10

  The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).
• IMIDAZO[1,2-a]PYRIDINE DERIVATIVES: PREPARATION AND PHARMACEUTICAL APPLICATIONS
  申请人：Lee Ken C.

  公开号：US20100105721A1

  公开（公告）日：2010-04-29

  The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).