2-溴辛酰溴 | 106265-08-1

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 中文名称: 2-溴辛酰溴
• 英文名称: 2-bromooctanoyl bromide
• CAS: 106265-08-1
• 化学式: C₈H₁₄Br₂O
• 分子量: 286.007
• InChiKey: QEJYOKHMHBRARP-UHFFFAOYSA-N

物化性质

• 沸点：
  256 ºC
• 密度：
  1.550
• 闪点：
  61 ºC

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-溴辛酰溴 、 (R)-3-羟基肉豆蔻酸甲酯 在 4-二甲氨基吡啶 、 potassium hydrogencarbonate 作用下， 以 甲醇 、 水 、 甲苯 为溶剂， 反应 3.5h， 以261.8 g的产率得到(R)-3-[(2-bromo-1-oxo-octyl)oxy]-tetradecanoic acid methyl ester
  参考文献：
  名称：

  不对称加氢和格氏试剂促进内酯环化的奥利司他新工艺中关键中间体的对映选择性合成

  摘要：

  描述了适用于大规模制备的奥利司他的新对映选择性合成。在其中，所述第一分离的关键中间体（[R）-3-己基-5,6-二氢-4-羟基-6-十一烷基-2- ħ吡喃-2-酮（12）通过（a）中的不对称氢化制备3-氧代十四烷甲酸甲酯为（S）-3-羟基十四烷酸酯（9）；（b）将9用2-溴辛酰基卤化物（溴化物/氯化物）酰化为（R）-3-[（2-溴-1-氧辛基）氧基]-十四烷酸甲酯（11），最后（c）叔丁基氯化镁促进11环化为单一对映体12。先前以对映异构体2的混合物形式发布的单一对映异构体中间体12已通过几个步骤进行到Orlistat（1），而无需进行任何工艺更改。

  DOI：

  10.1021/op060208q
• 作为产物：
  描述：

  辛酸 在 磷化氢 、 溴 、 sodium hydroxide 作用下， 生成 2-溴辛酰溴
  参考文献：
  名称：

  Sun, Zhaoyun; Peng, Xinhua; Dong, Xiongzi, Asian Journal of Chemistry, 2012, vol. 24, # 2, p. 929 - 930

  摘要：

  DOI：
• 作为试剂：
  描述：

  2-溴辛酰溴 、 3-羟基十四烷酸甲酯 在 2-溴辛酰溴 作用下， 生成 (R)-3-[(2-bromo-1-oxo-octyl)oxy]-tetradecanoic acid methyl ester
  参考文献：
  名称：

  Org. Process Res. Dev. 2007, 11, 524-533

  摘要：

  DOI：

文献信息

• Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
  申请人：Roche Colorado Corporation

  公开号：US20030171602A1

  公开（公告）日：2003-09-11

  The present invention relates to a novel process for producing a &dgr;-lactone of the formula: 1 using an acyl halide of the formula: 2 wherein R 1 , R 2 R 3 and X are described herein, as well as novel intermediates. In particular, the present invention relates to a process for enantioselectively producing the (R)-&dgr;-lactone.

  本发明涉及一种生产式1中&dgr;-内酯的新工艺，该工艺使用式2中的酰卤代物，其中R1，R2，R3和X如本文所述，以及新的中间体。特别地，本发明涉及一种对(R)-&dgr;-内酯进行对映选择性生产的工艺。
• EPOXY MODIFIED ACRYLIC RESIN AND PREPARATION METHOD THEREFOR, AND ENERGY-CURABLE COMPOSITION CONTAINING EPOXY MODIFIED ACRYLIC RESIN AND APPLICATION
  申请人：Changzhou Tronly New Electronic Materials Co., Ltd.

  公开号：EP3822260A1

  公开（公告）日：2021-05-19

  Provided are an epoxy modified acrylic resin and a preparation method therefor, an energy-curable composition containing epoxy modified acrylic resin and application. A branched chain of at least one repeat unit in the acrylic resin is grafted with one or more oxetane groups, and each oxetane group separately has the structure as represented by general formula (I), (II), or (III). After the branched chain of the acrylic resin is covalently grafted with the oxetane group, the epoxy modified acrylic resin is obtained. A coating prepared by using the composition containing the epoxy modified acrylic resin has good flexibility, as well as high adhesion and a great curing film forming speed for a coated substrate. The covalent grafting reaction does not affect the main chain structure of an original acrylic resin, and thus during downstream application, it is not necessary to change original devices and production processes, so that the investment costs are low.

  本发明提供了一种环氧改性丙烯酸树脂及其制备方法、一种含有环氧改性丙烯酸树脂的能量固化组合物及其应用。丙烯酸树脂中至少一个重复单元的支链与一个或多个氧杂环丁烷基团接枝，每个氧杂环丁烷基团分别具有通式（I）、（II）或（III）表示的结构。丙烯酸树脂的支链与氧杂环丁烷基团共价接枝后，就得到了环氧改性丙烯酸树脂。使用含有环氧改性丙烯酸树脂的组合物制备的涂层具有良好的柔韧性、高附着力和极快的固化成膜速度。共价接枝反应不会影响原有丙烯酸树脂的主链结构，因此在下游应用中无需改变原有装置和生产工艺，投资成本低。
• Compound, photocurable composition, cured product of same, printing ink, and printed matter curing the printing ink
  申请人：DIC Corporation

  公开号：US11079675B2

  公开（公告）日：2021-08-03

  A novel compound is used as a novel photopolymerization initiator, the novel compound having a molecular structure represented by general formula 1 below [R1 represents an alkyl group having 1 to 10 carbon atoms, R2 represents an alkyl group having 1 to 12 carbon atoms or the like, R3 represents an alkyl group having 1 to 12 carbon atoms or the like, R4 to R7 each independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or the like, Y1 represents an alkyl group having 3 to 19 carbon atoms or the like, Y2 represents an organic linking group, X1 represents an ethylene group or the like, X2 and X3 each represent an ethylene group or the like, Y3 represents a single bond or an alkylidene group, and n represents an integer of 1 to 3].

  一种新型化合物被用作新型光聚合引发剂，该新型化合物的分子结构如下通式 1 所示 [R1 代表具有 1 至 10 个碳原子的烷基，R2 代表具有 1 至 12 个碳原子的烷基或类似物，R3 代表具有 1 至 12 个碳原子的烷基或类似物，R4 至 R7 各自独立地代表氢原子、具有 1 至 8 个碳原子的烷基或类似物、Y1 代表具有 3 至 19 个碳原子的烷基或类似基团，Y2 代表有机连接基团，X1 代表乙烯基或类似基团，X2 和 X3 各自代表乙烯基或类似基团，Y3 代表单键或亚烷基，n 代表 1 至 3 的整数]。
• SYNTHESIS OF 3,6-DIALKYL-5,6-DIHYDRO-4-HYDROXY-PYRAN-2-ONE
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1255747A2

  公开（公告）日：2002-11-13
• NOVEL COMPOUND, PHOTOCURABLE COMPOSITION, CURED PRODUCT OF SAME, PRINTING INK, AND PRINTED MATTER SURING THE PRINTING INK
  申请人：DIC Corporation

  公开号：US20190137872A1

  公开（公告）日：2019-05-09

  A novel compound is used as a novel photopolymerization initiator, the novel compound having a molecular structure represented by general formula 1 below [R 1 represents an alkyl group having 1 to 10 carbon atoms, R 2 represents an alkyl group having 1 to 12 carbon atoms or the like, R 3 represents an alkyl group having 1 to 12 carbon atoms or the like, R 4 to R 7 each independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or the like, Y 1 represents an alkyl group having 3 to 19 carbon atoms or the like, Y 2 represents an organic linking group, X 1 represents an ethylene group or the like, X 2 and X 3 each represent an ethylene group or the like, Y 3 represents a single bond or an alkylidene group, and n represents an integer of 1 to 3].