N-ethyl-N-phenyl-4-methoxybenzamide | 329059-35-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-ethyl-N-phenyl-4-methoxybenzamide
• 英文别名: N-ethyl-4-methoxy-N-phenylbenzamide；N-Ethyl-(4-methoxy-benz)-anilid
• CAS: 329059-35-0
• 化学式: C₁₆H₁₇NO₂
• 分子量: 255.316
• InChiKey: IIWRQACQHVYDCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-ethyl-N-phenyl-4-methoxybenzamide 、 Diisobutylalan 在 乙醚 作用下， 生成 4-甲氧基苯甲醛
  参考文献：
  名称：

  Sacharkin; Chorlina, Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1959, p. 2146,2147, 2148; engl. Ausg. S. 2046, 2048

  摘要：

  DOI：
• 作为产物：
  描述：

  对甲氧基苯甲酰氯 、 N-乙基苯胺 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 N-ethyl-N-phenyl-4-methoxybenzamide
  参考文献：
  名称：

  [EN] N-TYPE CALCIUM CHANNEL INHIBITOR
  [FR] INHIBITEUR DE CANAL DE CALCIUM DE TYPE N

  摘要：

  This invention relates to an N-type calcium channel inhibitor drug containing a compound having an N-type calcium channel inhibitory action represented by the general formula (I) (wherein the symbols are as described in the specification), its salt, solvate, or prodrug. Since the compound of the present invention has an N-type calcium channel inhibitory action, it is useful as a preventive and/or therapeutic agent for N-type calcium channel-mediated diseases such as pain (e.g., acute pain, chronic pain, postoperative pain, cancer pain, neuropathic pain, infectious pain, etc.), cerebral infarction, transient cerebral ischemic attack, brain and spinal cord disorders after cardiac surgery, spinal cord vascular disorders, stress-induced hypertension, neurosis, epilepsy, asthma, frequent urination, eye diseases, etc.

  公开号：

  WO2006038594A1

文献信息

• HMF and furfural: Promising platform molecules in rhodium-catalyzed carbonylation reactions for the synthesis of furfuryl esters and tertiary amides
  作者：Xinxin Qi、Rong Zhou、Han-Jun Ai、Xiao-Feng Wu

  DOI：10.1016/j.jcat.2019.11.008

  日期：2020.1

  esters and tertiary amides has been developed. 5-Hydroxymethylfurfural (HMF) was used as both substrate and CO surrogate for the first time in a carbonylation reaction, and both alkyl and aryl iodides were tolerated well to afford the desired furfuryl esters in moderate to good yields. In addition, furfural was also utilized as a CO source for the synthesis of tertiary amides. A variety of tertiary amides

  已经开发了涉及铑催化的糠基酯和叔酰胺的羰基合成的生物质。在羰基化反应中，首次使用5-羟甲基糠醛（HMF）作为底物和CO替代物，烷基碘和芳基碘均耐受良好，以中等至良好的收率提供了所需的糠酸酯。另外，糠醛也用作合成叔酰胺的一氧化碳来源。以中等至优异的产率获得了具有良好官能团相容性的多种叔酰胺。值得注意的是，在不存在其他氧化剂的情况下，叔胺通过C N键裂解途径用作胺源。
• A novel Pd-catalyzed N-dealkylative carbonylation of tertiary amines for the preparation of amides
  作者：Tao Fang、Xu-Hong Gao、Ri-Yuan Tang、Xing-Guo Zhang、Chen-Liang Deng

  DOI：10.1039/c4cc07378a

  日期：——

  A novel and convenient protocol for the formation of amides via palladium-catalyzed N-dealkylative carbonylation of alkyl tertiary amines has been developed. In the presence of PdCl2(PhCN)2, CuO, PhCN and CO, a range of substituents on both aryl iodides and alkyl tertiary amines were compatible with the reaction to afford a series of N,N-disubstituted amides in moderate to excellent yields.

  开发了一种新颖方便的协议，通过钯催化的N-去烃基化羰基化反应形成酰胺。在PdCl2(PhCN)2、CuO、PhCN和CO的存在下，许多取代基的芳基碘化物和烷基三级胺均与该反应兼容，产出一系列N,N-二取代酰胺，产率中等至优良。
• [EN] N-TYPE CALCIUM CHANNEL INHIBITOR<br/>[FR] INHIBITEUR DE CANAL DE CALCIUM DE TYPE N
  申请人：ONO PHARMACEUTICAL CO

  公开号：WO2006038594A1

  公开（公告）日：2006-04-13

  　本発明は、一般式（Ｉ） （式中の記号は明細書中に記載の通り）で示されるＮ型カルシウムチャネル阻害作用を有する化合物、その塩もしくはそれらの溶媒和物またはそのプロドラッグを含有してなるＮ型カルシウムチャネル阻害薬に関する。　本発明化合物は、Ｎ型カルシウムチャネル阻害作用を有するので、Ｎ型カルシウムチャネル介在性疾患、例えば疼痛（例えば、急性痛、慢性痛、術後痛、癌性疼痛、神経痛、感染性疼痛等）、脳梗塞、一過性脳虚血発作、心臓手術後の脳脊髄障害、脊髄血管障害、ストレス性高血圧、神経症、てんかん、喘息、頻尿、眼疾患等の予防および／または治療剤として有用である。

  This invention relates to an N-type calcium channel inhibitor drug containing a compound having an N-type calcium channel inhibitory action represented by the general formula (I) (wherein the symbols are as described in the specification), its salt, solvate, or prodrug. Since the compound of the present invention has an N-type calcium channel inhibitory action, it is useful as a preventive and/or therapeutic agent for N-type calcium channel-mediated diseases such as pain (e.g., acute pain, chronic pain, postoperative pain, cancer pain, neuropathic pain, infectious pain, etc.), cerebral infarction, transient cerebral ischemic attack, brain and spinal cord disorders after cardiac surgery, spinal cord vascular disorders, stress-induced hypertension, neurosis, epilepsy, asthma, frequent urination, eye diseases, etc.
• Sacharkin; Chorlina, Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1959, p. 2146,2147, 2148; engl. Ausg. S. 2046, 2048
  作者：Sacharkin、Chorlina

  DOI：——

  日期：——