Z-L-ATANP(Boc)2-OH | 214350-91-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Z-L-ATANP(Boc)2-OH
• 英文别名: (S)-2-(benzyloxycarbonylamino)-3-(4,7-bis(tert-butoxycarbonyl)-1,4,7-triazonan-1-yl)propanoic acid；(2S)-3-[4,7-bis[(2-methylpropan-2-yl)oxycarbonyl]-1,4,7-triazonan-1-yl]-2-(phenylmethoxycarbonylamino)propanoic acid
• CAS: 214350-91-1
• 化学式: C₂₇H₄₂N₄O₈
• 分子量: 550.652
• InChiKey: CWBKOCWNUOFUOU-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  39
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  138
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  Z-L-ATANP(Boc)2-OH 在 N-羟基-7-氮杂苯并三氮唑 、 氢气 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 生成 Aib-L-ATANP(Boc)2-(Aib)2-OMe
  参考文献：
  名称：

  The First Water-Soluble 310-Helical Peptides

  摘要：

  Two water-soluble 3(10)-helical peptides are synthesized and fully characterized for the first time. The sequence of these terminally blocked heptamers comprises two residues of the Calpha-trisubstituted alpha-amino acid 2-amino-3-[1-(1,4,7-triazacyclononyl)]propanoic acid and five residues of a Calpha-tetrasubstituted alpha-amino acid (either alpha-aminoisobutyric acid or isovaline). Using CD and NMR techniques we were able to show that both heptapeptides are well structured in water, and that the type of conformation adopted is indeed the ternary 3(10)-helix.

  DOI：

  10.1002/1521-3765(20001215)6:24<4498::aid-chem4498>3.0.co;2-4
• 作为产物：
  描述：

  N-苄氧羰基-L-丝氨酸(Β-内酯) 、 1,4-di-tert-butyl 1,4,7-triazonane-1,4-dicarboxylate 以 乙腈 为溶剂， 反应 48.0h， 以65%的产率得到Z-L-ATANP(Boc)2-OH
  参考文献：
  名称：

  手性纳米酶-金纳米粒子为基础的能够进行对映体识别的转磷酸化催化剂

  摘要：

  首次证明了合成金属酶对RNA的对映选择性。含有手性Zn II结合头基的硫醇已在金纳米颗粒表面自组装。这导致手性双金属催化位点的自发形成，该手性双金属催化位点对RNA模型底物的对映异构体显示出不同的活性（k cat）。当将纳米酶应用于二核苷酸UpU，GpG，ApA和CpC的裂解时，观察到底物选择性，并且对映体纯的二核苷酸UpU的裂解观察到反应性的显着差异。

  DOI：

  10.1002/chem.201600853

文献信息

• A new ligand α-amino acid: (S)-2-amino-3-[1-(1,4,7-triazacyclononane)]propanoic acid
  作者：Paola Rossi、Fulvia Felluga、Paolo Scrimin

  DOI：10.1016/s0040-4039(98)01532-9

  日期：1998.9

  The title amino acid was obtained by regiospecific ring-opening reaction of Boc-diprotected 1,4,7-triazacyclononane with (S)-2-beazyloxycarbonylamino-beta-lactone 80% isolated yield) followed by deprotection. It strongly binds transition metal ions like Zn and Cu-II and can be incorporated in peptide sequences without affecting the metal ion affinity of the triazamacrocycle. (C) 1998 Elsevier Science Ltd. All rights reserved.
• Chiral Nanozymes-Gold Nanoparticle-Based Transphosphorylation Catalysts Capable of Enantiomeric Discrimination
  作者：Jack L.-Y. Chen、Cristian Pezzato、Paolo Scrimin、Leonard J. Prins

  DOI：10.1002/chem.201600853

  日期：2016.5.17

  the spontaneous formation of chiral bimetallic catalytic sites that display different activities (kcat) towards the enantiomers of an RNA model substrate. Substrate selectivity is observed when the nanozyme is applied to the cleavage of the dinucleotides UpU, GpG, ApA, and CpC, and remarkable differences in reactivity are observed for the cleavage of the enantiomerically pure dinucleotide UpU.

  首次证明了合成金属酶对RNA的对映选择性。含有手性Zn II结合头基的硫醇已在金纳米颗粒表面自组装。这导致手性双金属催化位点的自发形成，该手性双金属催化位点对RNA模型底物的对映异构体显示出不同的活性（k cat）。当将纳米酶应用于二核苷酸UpU，GpG，ApA和CpC的裂解时，观察到底物选择性，并且对映体纯的二核苷酸UpU的裂解观察到反应性的显着差异。
• The First Water-Soluble 310-Helical Peptides
  作者：Fernando Formaggio、Marco Crisma、Paola Rossi、Paolo Scrimin、Bernard Kaptein、Quirinus B. Broxterman、Johan Kamphuis、Claudio Toniolo

  DOI：10.1002/1521-3765(20001215)6:24<4498::aid-chem4498>3.0.co;2-4

  日期：2000.12.15

  Two water-soluble 3(10)-helical peptides are synthesized and fully characterized for the first time. The sequence of these terminally blocked heptamers comprises two residues of the Calpha-trisubstituted alpha-amino acid 2-amino-3-[1-(1,4,7-triazacyclononyl)]propanoic acid and five residues of a Calpha-tetrasubstituted alpha-amino acid (either alpha-aminoisobutyric acid or isovaline). Using CD and NMR techniques we were able to show that both heptapeptides are well structured in water, and that the type of conformation adopted is indeed the ternary 3(10)-helix.