N-(benzyloxy)-ethylene-diamine | 70922-93-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(benzyloxy)-ethylene-diamine
• 英文别名: N-(benzyloxy)ethylenediamine；O-Benzyl-N-(2-aminoaethyl)-hydroxylamin；N-Benzyloxy-ethylendiamin；(2-Aminoethyl)(benzyloxy)amine；N'-phenylmethoxyethane-1,2-diamine
• CAS: 70922-93-9
• 化学式: C₉H₁₄N₂O
• 分子量: 166.223
• InChiKey: BMIZFNZTVSHVPN-UHFFFAOYSA-N

物化性质

• 沸点：
  270.0±50.0 °C(Predicted)
• 密度：
  1.054±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  47.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(benzyloxy)-ethylene-diamine 以 乙醇 、 乙酸乙酯 、 丙酮 为溶剂， 生成 N-methyl-1-phenylmethoxyimidazolidin-2-imine
  参考文献：
  名称：

  1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists

  摘要：

  Screening of the Roche compound depository led to the identification of (1-benzyloxy-4,5-dihydro-1H-imidazol-2-yl)-butyl amine 4, a structurally novel NR1/2B Subtype selective NMDA receptor antagonist. The structure-activity relationships developed in this series resulted in the discovery of a novel class of potent and selective NMDA receptor blockers displaying activity in vivo. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00713-3
• 作为产物：
  描述：

  O-苄基羟胺 在 碳酸氢钠 、 一水合肼 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 N-(benzyloxy)-ethylene-diamine
  参考文献：
  名称：

  1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists

  摘要：

  Screening of the Roche compound depository led to the identification of (1-benzyloxy-4,5-dihydro-1H-imidazol-2-yl)-butyl amine 4, a structurally novel NR1/2B Subtype selective NMDA receptor antagonist. The structure-activity relationships developed in this series resulted in the discovery of a novel class of potent and selective NMDA receptor blockers displaying activity in vivo. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00713-3

文献信息

• 2-Imino-imidazolidine derivatives
  申请人：Hoffman-La Roche Inc.

  公开号：US04244957A1

  公开（公告）日：1981-01-13

  2-Imino-imidazolidine derivatives of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as hereinafter set forth, and pharmaceutically acceptable acid addition salts thereof, are described. The 2-imino-imidazolidine derivatives are useful in the treatment of hypertension.

  描述了公式##STR1##中R.sup.1、R.sup.2、R.sup.3和R.sup.4如下所述的2-亚胺-咪唑烷衍生物，以及其药学上可接受的酸盐。这些2-亚胺-咪唑烷衍生物在治疗高血压方面是有用的。
• Kolasa, Teodozyj; Chimiak, Andrzej, Polish Journal of Chemistry, 1981, vol. 55, # 5, p. 1163 - 1167
  作者：Kolasa, Teodozyj、Chimiak, Andrzej

  DOI：——

  日期：——
• ORGANIC NANOTUBE HAVING HYDROPHOBIZED INNER SURFACE, AND ENCAPSULATED MEDICINAL AGENT PREPARED USING THE NANOTUBE
  申请人：NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

  公开号：US20140147476A1

  公开（公告）日：2014-05-29

  Provided is an organic nanotube having a hydrophobized inner surface, formed by molecules including an asymmetric bipolar lipid molecule represented by the following General Formula (1) and a derivative thereof represented by the following General Formula (2), wherein the organic nanotube has a hydrophilized outer surface and a hydrophobized inner surface of a hollow cylinder and is formed by binary self-assembly, the organic nanotube encapsulates a hydrophobic guest in the hollow cylinder, has a function of refolding a denatured protein, and has a function of sustainably-releasing a hydrophobic drug according to the change in hydrophobicity of the inner surface of the tube or external stimulus, In Formulas (1) and (2), wherein the same symbols have the same meanings, G is a 1-glucopyranosyl group or 2-glucopyranosyl group, and n is an integer of 12 to 22. Particularly, an asymmetric bipolar lipid molecule and an ester thereof respectively represented by general formulae (1) and (2) wherein n is an integer of 18 to 22, both of Z 1 and Z 2 are single bonds, Y is Gly, m(s) is the same or different integer of 3 to 6, X is OH, and R is a methoxy group, an ethoxy group, or a benzyloxy group are novel substances, and can form a carboxylic acid based asymmetric nanotube by single component self-assembly or binary self-assembly.
• US4244957A
  申请人：——

  公开号：US4244957A

  公开（公告）日：1981-01-13
• US4355033A
  申请人：——

  公开号：US4355033A

  公开（公告）日：1982-10-19